Sex differences in clinical characteristics of migraine and its burden: a population‐based study

Chalmer, Mona Ameri; Kogelman, Lisette J. A.; Callesen, Ida; Christensen, Charlotte; Techlo, Tanya Ramdal; Møller, Peter L.; Davidsson, Olafur B.; Olofsson, Isa Amalie; Schwinn, Michael; Mikkelsen, Susan; Dinh, Khoa Manh; Nielsen, Kaspar René; Topholm, Mie; Erikstrup, Christian; Ostrowski, Sisse Rye; Pedersen, Ole Birger; Hjalgrim, Henrik; Banasik, Karina; Burgdorf, Kristoffer  S.; Nyegaard, Mette; Olesen, Jes; Hansen, Thomas

doi:10.1111/ene.15778

Cited by 16 publications

(15 citation statements)

References 49 publications

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“…Utilizing Denmark's blood bank infrastructure, DBDS actively recruits blood donors into the cohort. In addition to the register data that SCANDAT‐DK also incorporates, DBDS maintains information on self‐reported migraine, gathered from cross‐sectional electronic surveys administered to participants 8 …”

Section: Methodsmentioning

confidence: 99%

“…Migraine epidemiology varies markedly by sex and, 8 therefore, all statistical analyses were performed separately for females and males.…”

Section: Methodsmentioning

confidence: 99%

“…5 Furthermore, we have shown that the frequency of migraine among blood donors mirrors that of the general population, with only a selection against severe and chronic migraine noted among this group. 8…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the register data that SCANDAT-DK also incorporates, DBDS maintains information on self-reported migraine, gathered from cross-sectional electronic surveys administered to participants. 8…”

Section: Danish Blood Donor Studymentioning

confidence: 99%

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Blood donation and migraine relief: A national population cohort study in Denmark

Davidsson,

Rostgaard,

Chalmer

et al. 2024

Transfusion

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IntroductionMigraine is a prevalent neurological headache disorder. Due to challenges associated with finding effective treatment, many individuals with migraine feel compelled to explore alternative treatment strategies, such as blood donation, hypothesized to provide migraine relief.MethodsThrough logistic, Poisson, and Cox regression methods, we examined the links between migraine and blood donation activities in two population cohorts: Danish blood donors in the Scandinavian Donations and Transfusions Database (SCANDAT‐DK, N >1 million) and the Danish Blood Donor Study (N ~ 100,000).ResultsSCANDAT‐DK analyses showed no link between migraine and the propensity to become a blood donor among males (odds ratio [OR]Males = 0.95 [95% Confidence Interval: 0.86–1.04], and a reduced propensity among females ORFemales = 0.88 [0.83–0.93]). The incidence of migraine was not reduced upon blood donation (standardized incidence ratio [SIR]Males = 0.94 [0.83–1.06]; SIRFemales = 1.04 [0.99–1.10]). Donors with migraine demonstrated longer intervals between donations (hazard ratio [HR]Males = 0.87 [0.85–0.91], HRFemales = 0.80 [0.78–0.82]), and an increased risk of donor lapse (ORMales = 1.23 [1.14–1.32]; ORFemales = 1.28 [1.22–1.33]). Results were corroborated in DBDS using self‐reported migraine. Genetic predisposition to migraine associated with longer intervals in females (HRFemales = 0.98 [0.97–0.99]), but not in males.DiscussionOur findings do not support the hypothesis that blood donation serves as a viable treatment strategy among migraine patients. Future prospective investigations may help to elucidate the underlying biological mechanisms by which blood donation may influence migraine pathology.

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Section: Methodsmentioning

confidence: 99%

“…Migraine epidemiology varies markedly by sex and, 8 therefore, all statistical analyses were performed separately for females and males.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Danish Blood Donor Studymentioning

confidence: 99%

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Blood donation and migraine relief: A national population cohort study in Denmark

Davidsson,

Rostgaard,

Chalmer

et al. 2024

Transfusion

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“…This case-control study uses data from a population-based cohort of individuals with migraine from the Danish Migraine Population Cohort (DaMP), a subgroup of the Danish Blood Donor Study (DBDS), which is largely representative of the general Danish population with migraine. Written informed consent was obtained from all participants.…”

Section: Methodsmentioning

confidence: 99%

Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria

et al. 2023

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ImportanceThere is a need for better recognition and more extensive research into menstrual migraine (MM) in the general population, and a revision of the diagnostic criteria for MM is warranted to move the field forward. Increased understanding of MM is crucial for improving clinical care, diagnosis, and therapy for MM.ObjectivesTo assess the clinical characteristics of MM, including severity and treatment response, and to propose new diagnostic criteria for pure MM and menstrually related migraine.Design, Setting, and ParticipantsThis is a case-control study of Danish individuals with migraine. All individuals completed a 105-item validated diagnostic migraine questionnaire, sent via the Danish electronic mailing system (e-Boks) between May and August 2020, allowing diagnosis of pure MM and menstrually related migraine by the International Classification of Headache Disorders, Third Edition (ICHD-3). Data analysis was performed from September 2021 to November 2022.ExposureDiagnosis of migraine.Main Outcomes and MeasuresClinical characteristics of women with MM and women with nonmenstrual migraine (non-MM) were compared using the ICHD-3 diagnostic criteria. A simulation of the risk of randomly misclassifying MM was based on number of migraine attacks during 3 menstrual cycles (3 × 28 days), and simulation analyses were performed using 100 000 permutations of random migraine attacks in migraine patients.ResultsA total of 12 618 individuals, including 9184 women, with migraine participated in the study. Among the women with migraine, the prevalence of MM was 16.6% (1532 women), and the prevalence of non-MM was 45.9% (4216 women). The mean (SD) age was 38.7 (8.7) years for women with MM and 37.0 (9.2) years for women with non-MM. Of the 1532 women with MM, 410 (26.8%) fulfilled ICHD-3 diagnostic criteria for pure MM, 1037 (67.7%) fulfilled ICHD-3 diagnostic criteria for menstrually related migraine, and 152 (9.9%) fulfilled proposed diagnostic criteria for rare pure MM. MM was associated with a higher frequency of migraine-accompanying symptoms (odds ratio [OR], 1.98; 95% CI, 1.71-2.29), more frequent (OR, 7.21; 95% CI, 5.77-9.03) and more severe (OR, 1.17; 95% CI, 1.13-1.21) migraine attacks, lower frequency of nonmigraine headache (OR, 0.31; 95% CI, 0.18-0.49), an overall greater response to treatment with triptans (OR, 1.66; 95% CI, 1.24-2.24), better improvement of migraine attacks during late pregnancy (OR, 5.10; 95% CI, 2.17-14.00), and faster reappearance of migraine attacks post partum (OR, 3.19; 95% CI, 2.40-4.25). Hormonal contraceptive–related MM was associated with a higher prevalence of migraine without aura than migraine related to spontaneous menstruation (OR, 1.82; 95% CI, 1.62-2.06). Otherwise, no differences between hormonal and spontaneous MM were observed. The risk of random diagnostic misclassification of ICHD-3 menstrually related migraine in women with high frequency episodic migraine was 43%. This risk was reduced to 3% when applying the proposed criteria for menstrually related migraine.Conclusions and RelevanceIn this case-control study, MM in the general population had clinical characteristics that were quantitively different from those of non-MM. Detailed descriptive data and suggested improved diagnostic criteria for pure MM and menstrually related migraine were provided.

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Efficacy and safety of venlafaxine versus nortriptyline for the preventive treatment of migraine: A double-blind randomized clinical trial

Roghani,

Ghaedi,

Iranzadeh

et al. 2024

Clinical Neurology and Neurosurgery

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Sex differences in clinical characteristics of migraine and its burden: a population‐based study

Cited by 16 publications

References 49 publications

Blood donation and migraine relief: A national population cohort study in Denmark

Blood donation and migraine relief: A national population cohort study in Denmark

Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria

Efficacy and safety of venlafaxine versus nortriptyline for the preventive treatment of migraine: A double-blind randomized clinical trial

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