Sex differences in EEG in adult gonadectomized rats before and after hormonal treatment

Río-Portilla, I. Del; Ugalde, Edmundo Granda; Juárez, José Antonio Caballero; Roldán, Aurora González; Corsi-Cabrera, María

doi:10.1016/s0306-4530(97)00056-5

Cited by 16 publications

(11 citation statements)

References 80 publications

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“…These results suggest that the neonatal castration increases the generalized corticalÐover hippocampalÐactivation, resulting in a feminine-like EEG pattern (Jua Ârez & Corsi-Cabrera, 1995;Jua Ârez et al, 1995). Further support to this conclusion is given by the ®nding that sex differences for delta and theta RP were reported in control rats (Del Rõ Âo Portilla et al, 1998) and that prenatal testosterone decreases beta RP only in females (Jua Ârez et al, 1995). These data also point to the vulnerability of the mechanisms underlying cortical activation in males during neonatal development and agrees with the greater susceptibility to frontal cortex lesions (Starkstein et al, 1989) and to environmental in¯uences on the cortex induced by rearing in impoverished or enriched environments shown by males (Juraska, 1984).…”

Section: Discussionmentioning

confidence: 91%

“…Additionally, on the basis of the experimental design, males lacked testes while females possessed highly de®cient ovaries: polyfolicular without corpora lutea and progesterone production (Swanson & van der Werff ten Bosch, 1964;Dõ Âaz et al, 1995). Importantly, it has been demonstrated that the administration (by exogenous injection) or withdrawal (by gonadectomy) of steroid hormones affect speci®c aspects of the EEG pattern both in adult males and females (del Rõ Âo Portilla, Ugalde, Jua Ârez, Rolda Ân, & Corsi-Cabrera, 1997). Therefore, the ®nal objective of the present study was to discern if the observed EEG effects of pre-or neonatal manipulation were due to the absence of steroids during adulthood.…”

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confidence: 90%

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Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

et al. 2000

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Section: Discussionmentioning

confidence: 91%

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confidence: 90%

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

et al. 2000

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“…Task-driven gender differences have been reported in humans for EEGs in spectral power analysis, especially in interhemispheric correlations. [50][51][52] Studies to evaluate the effect of sex hormones on EEG [53][54][55] have revealed different inter-and intrahemispheric functional organization by sex.…”

Section: Factors Influencing Control Eeg Patternsmentioning

confidence: 99%

Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

Kadam

D’Ambrosio

Duveau³

et al. 2017

Epilepsia

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SUMMARY In vivo electrophysiological recordings are widely used in neuroscience research and video-electroencephalography (vEEG) has become a mainstay of preclinical neuroscience research, including studies of epilepsy and cognition. Studies utilizing vEEG typically involve comparison of measurements obtained from different experimental groups, or from the same experimental group at different times, in which one set of measurements serves as “control”, and the others as “test” of the variables of interest. Thus, controls provide mainly a reference measurement for the experimental test. Control rodents represent an undiagnosed population, and cannot be assumed to be “normal” in the sense of being “healthy.” Certain physiological EEG patterns seen in humans are also seen in control rodents. However, interpretation of rodent vEEG studies relies on documented differences in frequency, morphology, type, location, behavioral state dependence, reactivity and functional or structural correlates of specific EEG patterns and features between control and test groups. This paper will focus on the vEEG of standard laboratory rodent strains with the aim of developing a small set of practical guidelines that can assist researchers in the design, reporting, and interpretation of future vEEG studies. To this end, we will: 1) discuss advantages and pitfalls of common vEEG techniques in rodents and propose a set of recommended practices and 2) present EEG patterns and associated behaviors recorded from adult rats of a variety of strains. We will describe the defining features of selected vEEG patterns (brain-generated or artifactual) and note similarities to vEEG patterns seen in adult humans. We will note similarities to normal variants or pathological human EEG patterns and defer their interpretation to a future report focusing on rodent seizure patterns.

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“…It was hypothesized that baseline LFP would vary depending on hormonal state, as sex steroids have organizational actions and activational influences on the activity of neuronal networks, as measured by cortical EEG, throughout the rat estrous cycle [36]. Differences in baseline LFP were only seen in a period of low sexual receptivity, metestrus, which has been demonstrated above to be a time when single unit firing is substantially different.…”

Section: Pvn Local Field Potential Recordingsmentioning

confidence: 99%

Neuronal Activity in the Hypothalamic Paraventricular Nucleus Varies Across the Estrous Cycle in Anesthetized Female Rats: Effects of Dopamine Receptor Agonism

Richards

Wayman

Allers

2010

The Journal of Sexual Medicine

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Purpose The central nervous system plays a pivotal role in sexual behavior. The role of the paraventricular nucleus (PVN) of the hypothalamus in female sexual behavior is poorly characterized. In males, there is a correlation between PVN neuron activity and erectile activity, and in mediating dopamine receptor agonist-induced sexual arousal. Material and Methods To understand the role of the PVN in female sexual function, baseline PVN neuronal activity and responses to dopamine receptor agonism were assessed in anesthetized rats. Single unit recordings were used to assess the firing properties of individual PVN neurons; and local field potentials quantified PVN network activity (combined activity of large numbers of PVN neurons). Baseline and apomorphine-stimulated activity was measured across the estrous cycle. Results Baseline firing rates of single units were found to differ across the stages of the estrous cycle with metestrus showing the highest firing rate (3.7 vs. 0.9 Hz in diestrus). Apomorphine administration caused significant increases in firing rate in 29% of neurons, and significant decreases in 71%. Basal local field potentials also varied between estrous stages and in response to apomorphine; significant differences in the total power of alpha1 and beta1 bands were observed in both cases. Conclusions This study shows that PVN neuronal activity varies with hormonal state, and these neurons are differentially affected by apomorphine, suggesting two different populations. These data are indicative of a critical role for the PVN in female sexual function. It is important that the hormonal state should be considered when investigating sexual physiology and the effect of pharmacological agents.

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Sex differences in EEG in adult gonadectomized rats before and after hormonal treatment

Cited by 16 publications

References 80 publications

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

Neuronal Activity in the Hypothalamic Paraventricular Nucleus Varies Across the Estrous Cycle in Anesthetized Female Rats: Effects of Dopamine Receptor Agonism

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