Sex differences in frailty: Comparisons between humans and preclinical models

Kane, Alice E.; Howlett, Susan E.

doi:10.1016/j.mad.2021.111546

Cited by 74 publications

(42 citation statements)

References 102 publications

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“…Kane and Howlett, 2021;Oksuzyan et al, 2008).Summary measures of health such as the FI exhibit an accelerating accumulation of health deficits with age(Mitnitski et al, 2001;2005;2012;2013). This universally observed behavior must be reflected in either increasing damage rates with age, or decreasing repair rates(Pyrkov et al., 2021), oras we findboth.…”

supporting

confidence: 60%

“Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions”

Farrell

Kane

Bisset

et al. 2022

Preprint

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As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal data. We extract damage and repair rates from repeated observations of health deficits in mice and humans to explore the contribution of robustness and resilience, which respectively decrease damage rates and increase repair rates, to aging health. We find a conserved decline with age in robustness and resilience in mice and humans, implying that both contribute to worsening health in aging. A decline in robustness, however, has a greater effect than a decline in resilience on accelerating damage accumulation with age, and a greater association with reduced survival. We also find that deficits are damaged and repaired over a wide range of timescales ranging from the shortest measurement scales towards organismal lifetime timescales. We explore the effect of systemic interventions that have been shown to improve health, including the angiotensin-converting enzyme inhibitor enalapril and voluntary exercise for mice, and household wealth for humans. We find that these interventions affect both damage and repair rates – but in different proportions for different interventions. These findings have implications for how health in aging, and interventions targeting health, are conceptualized and assessed.

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supporting

confidence: 60%

“Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions”

Farrell

Kane

Bisset

et al. 2022

Preprint

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“…Frailty is associated with an increased risk of adverse consequences, including functional decline, deterioration, multiple hospitalizations and death, and is an important public health concern in aging societies 1 – 6 . Clinical literature over the past several decades has identified clear sex differences in frailty, typically reporting that women have a higher prevalence and risk of frailty 7 – 11 . Women are also reported to have a higher prevalence of muscle weakness, lower bone density and a higher risk of future fractures associated with a decrease in female hormone levels with menopause, and are at a higher risk of decline in walking ability and becoming bedridden from frailty than males 13 , 70 – 73 .…”

Section: Introductionmentioning

confidence: 99%

Kinematic characteristics during gait in frail older women identified by principal component analysis

Tsuchida

Kobayashi

Inoue

et al. 2022

Sci Rep

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Frailty is associated with gait variability in several quantitative parameters, including high stride time variability. However, the associations between joint kinematics during walking and increased gait variability with frailty remain unclear. In the current study, principal component analysis was used to identify the key joint kinematics characteristics of gait related to frailty. We analyzed whole kinematic waveforms during the entire gait cycle obtained from the pelvis and lower limb joint angle in 30 older women (frail/prefrail: 15 participants; non-frail: 15 participants). Principal component analysis was conducted using a 60 × 1224 input matrix constructed from participants’ time-normalized pelvic and lower-limb-joint angles along three axes (each leg of 30 participants, 51 time points, four angles, three axes, and two variables). Statistical analyses revealed that only principal component vectors 6 and 9 were related to frailty. Recombining the joint kinematics corresponding to these principal component vectors revealed that frail older women tended to exhibit greater variability of knee- and ankle-joint angles in the sagittal plane while walking compared with non-frail older women. We concluded that greater variability of knee- and ankle-joint angles in the sagittal plane are joint kinematic characteristics of gait related to frailty.

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“…Despite being frailer, women are at lower mortality risk. These sex-specific effects are likely resulting from a combination of behavioral, social, and biological factors, and they then have different consequences for disease susceptibility, treatment, and outcomes in frailty [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Guava Fruit and Acacia pennata Vegetable Intake Association with Frailty of Older Adults in Northern Thailand

et al. 2022

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As Thailand moves toward an aging society, frailty has become a concern amongst northern Thai elderly. The causes of frailty are multifactorial and include genetic, environmental, and socio-economic factors; diet is of particular interest. A cross-sectional study was conducted from September to October 2017 to investigate what kind of diets normally consumed by 350 Thai elders were associated with frailty using a questionnaire and frailty determination by Fried’s phenotype followed by phytochemical analyses of the diets. The multivariable logistic regression analysis demonstrated a significant positive association between certain foods and lower frailty. Guava fruit and Acacia pennata vegetable consumption had lower odds of frailty, which were 0.52 times (95% CI 0.28–0.96, p = 0.037) and 0.42 times (95% CI 0.21–0.83, p = 0.012) when adjusted for the potential confounders. The phytochemical analyses of guava fruit showed a significantly higher amount of total flavonoids (p < 0.001), total phenolic compounds (p = 0.002), and antioxidant capacity, including DPPH (p < 0.001), ABTS (p < 0.001), and FRAP (p = 0.002) when compared to those of banana. Acacia pennata vegetable contained a significantly higher amount of total phenolic compounds (p = 0.012) when compared to those of lettuce. These findings may assist in health promotion programs of frailty prevention by encouraging an increase in consumption of either guava fruit or Acacia pennata vegetable among Thai elderly.

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Sex differences in frailty: Comparisons between humans and preclinical models

Cited by 74 publications

References 102 publications

“Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions”

“Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions”

Kinematic characteristics during gait in frail older women identified by principal component analysis

Guava Fruit and Acacia pennata Vegetable Intake Association with Frailty of Older Adults in Northern Thailand

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