1994
DOI: 10.1007/bf00228750
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Sex differences in GABA/benzodiazepine receptor changes and corticosterone release after acute stress in rats

Abstract: Since many hormonal indices of stress responsiveness are sexually dimorphic in rats, we examined sex differences and the effects of gonadectomy on the stress-related changes in GABAA/benzodiazepine receptors in rats. Intact or ovariectomized female rats displayed a markedly greater corticosterone response and a more pronounced increase in benzodiazepine receptors than males (intact or orchidectomized) after acute handling or swim stress. Swim stress increased benzodiazepine receptor density without modifying a… Show more

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Cited by 84 publications
(28 citation statements)
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“…Given that females and males often respond differently to acute stressors (e.g., [214]), it is not clear whether daily handling of males adequately controls for this potential confound.…”
Section: Testing Across the Estrous Cycle: Animal Studiesmentioning
confidence: 99%
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“…Given that females and males often respond differently to acute stressors (e.g., [214]), it is not clear whether daily handling of males adequately controls for this potential confound.…”
Section: Testing Across the Estrous Cycle: Animal Studiesmentioning
confidence: 99%
“…One of the most reliable and simple ways to determine stage of the estrous cycle in rodents, sampling vaginal cytology, requires that females be handled and probed daily for at least two cycles (approximately 8-10 days). Given that females and males often respond differently to acute stressors (e.g., [214]), it is not clear whether daily handling of males adequately controls for this potential confound. Obtaining repeated vaginal samples in rodents also may affect sensitivity to drugs [209].…”
Section: Testing Across the Estrous Cycle: Animal Studiesmentioning
confidence: 99%
See 1 more Smart Citation
“…Alterations in GABAergic neurotransmission during times of stress have been proposed to modulate the stress response (33)(34)(35)(36), which underlies the therapeutic activity of benzodiazepines in anxiety and stress management. The anxiety-like behavioral effects observed in the GAD65-deficient mice are consistent with the suggested role of GABAergic neurotransmission in animal models of anxiety.…”
Section: Discussionmentioning
confidence: 99%
“…We have proposed that all of these signals converge to modulate neuronal plasticity process. In fact, both ovarian steroids (Earley & Leonard, 1980;Wilson & Biscardi, 1994) and stress (Biggio & Concas, 1984;Purdy et al, 1991;Akinci & Johnston, 1997) are able to modify the number and affinity of GABA-A receptors in several regions of the CNS. The GABA-A receptor is also a major target of neurosteroids (Robel & Baulieu, 1994) whose concentrations fluctuate in the brain as a function of the ovulatory cycle (Karavolas & Hodges, 1990) and stress (Paul & Purdy, 1992;Korneyev et al, 1993).…”
Section: Stress and Ovarian Hormone Interactionsmentioning
confidence: 99%