Sex differences in learning and memory following short‐term dietary restriction in the rat

Rajab, Ebrahim; Alqanbar, Batool; Naiser, Mohammed J.; Abdulla, Habib A.; Al‐Momen, Monaf M.; Kamal, Amer

doi:10.1016/j.ijdevneu.2014.05.011

Cited by 20 publications

(21 citation statements)

References 45 publications

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“…Rolls et al (2011) demonstrated that increasing the frequency of microarousal events during sleep caused corresponding cognitive deficits [34], suggesting that hunger-induced increases in microarousals may negatively impact animal cognition and behavioral performance. Indeed, food deprivation has been shown to affect cognitive performance in rats [61, 62]. Our results showing that modulating AgRP or POMC neurons alters the frequency of microarousal events during NREM sleep in mice may therefore have consequences for animal cognition as well as for sleep/wake architecture and NREM sleep integrity.…”

Section: Discussionmentioning

confidence: 69%

Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need

et al. 2018

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SUMMARY Eating and sleeping represent two mutually exclusive behaviors that satisfy distinct homeostatic needs. Because an animal cannot eat and sleep at the same time, brain systems that regulate energy homeostasis are likely to influence sleep/wake behavior. Indeed, previous studies indicate that animals adjust sleep cycles around periods of food need and availability. Furthermore, hormones that affect energy homeostasis also affect sleep/wake states: the orexigenic hormone ghrelin promotes wakefulness, while the anorexigenic hormones leptin and insulin increase the duration of slow wave sleep. However, whether neural populations that regulate feeding can influence sleep/wake states is unknown. The hypothalamic arcuate nucleus contains two neuronal populations that exert opposing effects on energy homeostasis: agouti-related protein (AgRP)-expressing neurons detect caloric need and orchestrate food-seeking behavior, while activity in pro-opiomelanocortin (POMC)-expressing neurons induces satiety. We tested the hypotheses that AgRP neurons affect sleep homeostasis by promoting states of wakefulness, while POMC neurons promote states of sleep. Indeed, optogenetic or chemogenetic stimulation of AgRP neurons in mice promoted wakefulness while decreasing the quantity and integrity of sleep. Inhibition of AgRP neurons rescued sleep integrity in food-deprived mice, highlighting the physiological importance of AgRP neuron activity for the suppression of sleep by hunger. Conversely, stimulation of POMC neurons promoted sleep states and decreased sleep fragmentation in food-deprived mice. Interestingly, we also found that sleep deprivation attenuated the effects of AgRP neuron activity on food intake and wakefulness. These results indicate that homeostatic feeding neurons can hierarchically affect behavioral outcomes depending on homeostatic need.

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Section: Discussionmentioning

confidence: 69%

Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need

et al. 2018

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“…Several studies have demonstrated the presence of sex differences in the response to the ABA protocol, with males losing more weight than females (Carrera, Gutierrez, & Boakes, ; Doerries, Stanley, & Aravich, ). Moreover, other authors have shown that males are more sensitive to food restriction than females (Lenglos, Mitra, Guevremont, & Timofeeva, ; Rajab et al, ). Our data confirmed a greater repercussion of the ABA protocol in males than in females, indicating a sex‐specific response to certain stress or to the cumulative effect of several stressors.…”

Section: Discussionmentioning

confidence: 95%

Sexually dimorphic behavioral effects of maternal separation in anorexic rats

Farinetti

Aspesi

Marraudino

et al. 2019

Developmental Psychobiology

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Exposure to negative events during the neonatal period is one of the leading factors contributing to the development of psychiatric disorders, including anorexia nervosa. In this study, we investigated the effects of maternal separation (MS) on the development of anorexia in rodents using the mild‐stress form of the activity‐based anorexia (ABA) model (2 hr of free access to a running wheel and a 1‐hr feeding test) in both male and female rats. We assessed anxiety‐like and locomotor behavior and hyperactivity with the open field and elevated plus maze tests. Our results showed that ABA rats of both sexes displayed hyperactive behavior associated with reduced anxiety‐like behavior when compared to controls. However, a sexually dimorphic effect of MS emerged in anorexic rats: while the females exposed to MS + ABA were hyperactive with diminished anxiety‐related behaviors compared to females of the ABA group, MS in males attenuated or did not alter the effects of the ABA protocol. In conclusion, our data reveal that the synergistic effects of MS and ABA on physical activity and anxiety‐like behavior act in opposite directions in the two sexes.

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“…Studies with subtle FR, DR or CR have exhibited the enhancement effects (Ko et al, 2015). For example, 2 h of 40% DR for 5 consecutive days increased learning and memory in water maze in adult mice (Rajab et al, 2014). After 1‐h ITI, however, acute FR for 24 h impaired the retention.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that FR attenuated age-related deficits in learning and memory in rodents (Yang et al, 2014) and improved cognitive performance in models of neurodegenerative diseases (Brownlow et al, 2014). However, other studies reported neutral or negative effects of FR on cognitive function in different animal models (Khabour et al, 2010;Oliveira-Silva et al, 2007;Rajab et al, 2014;Tucci et al, 2006;Yanai et al, 2004). No significant effect by FR was observed on the disruptive memory caused by aging process in the water maze in rats (Oliveira-Silva et al, 2007).…”

Section: Introductionmentioning

confidence: 97%

Food restriction affects Y‐maze spatial recognition memory in developing mice

Chen

et al. 2017

Intl J of Devlp Neuroscience

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The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.

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Sex differences in learning and memory following short‐term dietary restriction in the rat

Cited by 20 publications

References 45 publications

Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need

Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need

Sexually dimorphic behavioral effects of maternal separation in anorexic rats

Food restriction affects Y‐maze spatial recognition memory in developing mice

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