Sex differences in markers of metabolic syndrome and adipose tissue inflammation in obesity-prone, Osborne-Mendel and obesity-resistant, S5B/Pl rats

Poret, Jonquil M.; Gaudet, Darryl A.; Braymer, Hugh D.; Primeaux, Stefany D.

doi:10.1016/j.lfs.2021.119290

Cited by 7 publications

(2 citation statements)

References 74 publications

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“…This phenomenon, in which an individual has the same genetic background but exhibits different responses to the same HFD, is known as obesity-prone (OP) and obesity-resistant (OR) (InSurk, 2003). Previous studies have reported differences in body weight regulation, oxidative stress, and energy metabolism between OP and OR rats (Lu et al, 2021;Poret et al, 2021;Yu et al, 2018). For example, OR rats were found to have significantly upregulated myoglobin, but significantly downregulated tropomyosin R and troponin I, indicating that this group can effectively regulate muscle contraction, increase glucose utilization, and maintain lighter weight (Dong Hyun, 2011).…”

Section: Introductionmentioning

confidence: 98%

Sodium butyrate protects against oxidative stress in high‐fat‐diet‐induced obese rats by promoting GSK‐3β/Nrf2 signaling pathway and mitochondrial function

Tang

Sun

et al. 2022

Journal of Food Biochemistry

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Sodium butyrate (NaB), obtained by fermenting dietary fiber via intestinal microflora, was recently shown to improve the activity of some antioxidant enzymes in vivo. This study aims to investigate the term changes of mitochondrial energy metabolism and redox homeostasis in skeletal muscles and clarify the regulatory mechanism and dose effect of NaB on skeletal muscle. Male Sprague-Dawley rats were divided into the control group, obesity-prone (OP) group and obesity-resistant (OR) group based on the gain of body weight after 8 weeks' of feeding high-fat diet (HFD), followed by sacrificing rats at the end of 20th week. NaB intervention (12 weeks) could effectively reduce the body weight of rats in the OP and OR groups. NaB also mediated upregulation of antioxidant enzyme activity and GSH/GSSG ratio, while reducing reactive oxygen species (ROS) levels and malondialdehyde (MDA) content. At the molecular level, NaB upregulated Pi3k, Nrf2, Nqo-1, and Ho-1, but downregulated Gsk-3β mRNA expression by regulating the Nrf2 antioxidant pathway to enhance tissue antioxidant capacity. At the same time, NaB intervention significantly upregulated Glut4, Irs-1, Pdx1, and MafA, expression in gastrocnemius muscles of OP and OR rats, and elevated insulin secretion and muscle insulin sensitivity. Thus, NaB activates antioxidant pathway, improves the antioxidant capacity of obese rat tissues and promotes glucose metabolism. Practical applicationsThis study found that obesity-prone and obesity-resistant rats have differences in mitochondrial redox homeostasis and energy metabolism in tissues. Meanwhile, sodium butyrate can effectively promote muscle protein synthesis, increase insulin sensitivity, and promote glucose metabolism in obesity rats. Thus, sodium butyrate supplementation or increasing intestinal butyrate production (e.g., by consuming foods rich in dietary fiber) is a potential means of improving the body's glucose metabolism and obesity profile.

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Section: Introductionmentioning

confidence: 98%

Sodium butyrate protects against oxidative stress in high‐fat‐diet‐induced obese rats by promoting GSK‐3β/Nrf2 signaling pathway and mitochondrial function

Tang

Sun

et al. 2022

Journal of Food Biochemistry

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“…These inflammatory manifestations of obese adipose tissue have been linked to insulin resistance, metabolic syndrome, and type 2 diabetes. A number of experimental models of obesity from genetic [ 10 ] to high-fat diets administration [ 11 , 12 ] have been developed, to analyze this syndrome [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Melatonin on Redox Enzymes Daily Gene Expression in Perirenal and Subcutaneous Adipose Tissue of a Diet Induced Obesity Model

Fernández-Mateos

Cano-Barquilla

Jiménez-Ortega

et al. 2023

IJMS

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Increased adiposity is related to oxidative stress, inflammation and metabolic disorders. Our group has shown that melatonin totally or partially prevents the alterations that obesity causes in some neuroendocrine and inflammatory parameters indicative of oxidative stress. This study analyzes the effects of HFD on the relative gene expression of several redox balance enzymes on adult male Wistar rats subcutaneous (SAT) and perirenal adipose tissue (PRAT) and the possible preventive role of melatonin. Three experimental groups were established: control, high fat diet (HFD) and HFD plus 25 μg/mL melatonin in tap water. After 11 weeks, animals were sacrificed at 09:00 a.m. and 01:00 a.m. and PRAT and SAT were collected for selected redox enzymes qRT-PCR. Differential expression of redox enzyme genes, except for SODMn, GPx and catalase, was observed in the control group as a function of fat depot. HFD causes the disappearance of the temporal changes in the expression of the genes studied in the two fat depots analyzed. PRAT seems to be more sensitive than SAT to increased oxidative stress induced by obesity. Melatonin combined with a HFD intake, partially prevents the effects of the HFD on the gene expression of the redox enzymes. According to our results, melatonin selectively prevents changes in the relative gene expression of redox enzymes in PRAT and SAT of animals fed an HFD.

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The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy

Martin

Primeaux

2023

Peptides

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Sex differences in markers of metabolic syndrome and adipose tissue inflammation in obesity-prone, Osborne-Mendel and obesity-resistant, S5B/Pl rats

Cited by 7 publications

References 74 publications

Sodium butyrate protects against oxidative stress in high‐fat‐diet‐induced obese rats by promoting GSK‐3β/Nrf2 signaling pathway and mitochondrial function

Sodium butyrate protects against oxidative stress in high‐fat‐diet‐induced obese rats by promoting GSK‐3β/Nrf2 signaling pathway and mitochondrial function

Effect of Melatonin on Redox Enzymes Daily Gene Expression in Perirenal and Subcutaneous Adipose Tissue of a Diet Induced Obesity Model

The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy

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