Sex differences in oxidative stress after eccentric and concentric exercise

Więcek, Magdalena; Maciejczyk, Marcin; Szymura, Jadwiga; Szyguła, Zbigniew

doi:10.1080/13510002.2017.1304195

Cited by 14 publications

(22 citation statements)

References 37 publications

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“…In our earlier research, we demonstrated that exercises at supramaximal ( Wiecek et al, 2015b , 2017a ), maximal ( Wiecek et al, 2015a , 2017b ), and submaximal intensities ( Wiecek et al, 2017c ) have influence on redox balance in the blood of women and men, and their effects are different depending on the intensity and duration of the effort as well as the type of engaged muscle work.…”

Section: Introductionmentioning

confidence: 99%

Anaerobic Exercise-Induced Activation of Antioxidant Enzymes in the Blood of Women and Men

et al. 2018

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Objective: Physical exercise changes redox balance in the blood. The study aim is to determine gender-related differences in enzymatic antioxidant defense [superoxide dismutase, catalase (CAT), and glutathione peroxidase (GPx)] during the initial period following anaerobic exercise and 24 h after its completion.Methods: Young, non-training participants (10 women and 10 men) performed a single anaerobic exercise, which was a 20-s maximal cycling sprint test. Blood was collected before and after completing the anaerobic exercise, i.e., after 3, 15, 30, and 60 min and after 24 h. Lactate concentration, and the superoxide dismutase, CAT, and GPx activity were determined. The results were adapted to the changes in plasma volume.Results: Anaerobic exercise induced a significant increase in lactate concentration, similar among both sexes. Anaerobic exercise evokes identical changes in the activity of antioxidant enzymes in the blood plasma of women and men, which is dependent on anaerobic capacity. In the early phase of restitution, the activity of antioxidant enzymes decreases; 24 h after anaerobic exercise, GPx activity in the blood plasma of women and men is higher than before the exercise.Conclusion: There are no gender-related differences concerning changes in plasma antioxidant activity after anaerobic exercise. Depending on the antioxidant enzyme, changes of activity differ in time after the end of the anaerobic exercise.

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Section: Introductionmentioning

confidence: 99%

Anaerobic Exercise-Induced Activation of Antioxidant Enzymes in the Blood of Women and Men

et al. 2018

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“…Moreover, the fact that no differences were found between sexes in muscle damage explains the absence of differences also found in oxidative stress. In contrast, in a recent study, it was shown that eccentric exercise caused impaired redox balance only in women [27].…”

Section: Discussionmentioning

confidence: 82%

The Effects of Eccentric Exercise on Muscle Damage and Blood Redox Status in Men and Women

Nikolaidis

2017

JFMK

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Abstract:The purpose of the present investigation was to study the possible differences between men and women in muscle damage indices and oxidative stress biomarkers in response to eccentric exercise. Ten males and ten females performed a bout of eccentric exercise using an isokinetic dynamometer. Muscle damage indices (i.e., isometric torque, range of movement, delayed onset muscle soreness, and creatine kinase (CK)) and oxidative stress biomarkers (i.e., protein carbonyls and glutathione) were measured before and 48 h after eccentric exercise. No significant main effect of group or time-group interaction was found for muscle damage indices and oxidative stress biomarkers. However, the main effect of time was significant for all measured parameters. The findings of the present investigation indicate that eccentric exercise caused muscle damage and oxidative stress (i.e., protein and glutathione oxidation) in both males and females with no significant differences between the two groups. It is concluded that there are no differences between males and females regarding muscle damage and oxidative stress after eccentric exercise.

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“…However, ageand/or disease-induced alterations in sex hormones are major contributors to muscle wasting, and hence males and females may respond differently to DDx due to their unique hormonal profiles. Moreover, sex differences in the level of skeletal muscle oxidative stress, such as those recently reported to occur after eccentric exercise indicate women respond with accentuated impaired redox balance compared with men (Wiecek et al, 2017). Thus, it is possible, and more than likely, that differences in the level or the type of post-translational modification may be different between skeletal muscle in males and in females, which may contribute to sexdifferences in susceptibility to DDx exposure.…”

Section: Discussionmentioning

confidence: 99%

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

Truong

Cherednichenko

Pessah

2019

Toxicological Sciences

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Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-gated sodium channels, it mediates toxicity in mammals by acting as an endocrine disruptor (ED). Numerous studies demonstrate DDT/DDE to be EDs, but studies examining muscle-specific effects mediated by nonhormonal receptors in mammals are lacking. Therefore, we investigated whether o,p′-DDT, p,p′-DDT, o,p′-DDE, and p,p′-DDE (DDx, collectively) alter the function of ryanodine receptor type 1 (RyR1), a protein critical for skeletal muscle excitation-contraction coupling and muscle health. DDx (0.01–10 µM) elicited concentration-dependent increases in [3H]ryanodine ([3H]Ry) binding to RyR1 with o,p′-DDE showing highest potency and efficacy. DDx also showed sex differences in [3H]Ry-binding efficacy toward RyR1, where [3H]Ry-binding in female muscle preparations was greater than male counterparts. Measurements of Ca2+ transport across sarcoplasmic reticulum (SR) membrane vesicles further confirmed DDx can selectively engage with RyR1 to cause Ca2+ efflux from SR stores. DDx also disrupts RyR1-signaling in HEK293T cells stably expressing RyR1 (HEK-RyR1). Pretreatment with DDx (0.1–10 µM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner. o,p′-DDE (24 h; 1 µM) significantly increased Ca2+-transient amplitude from electrically stimulated mouse myotubes compared with control and displayed abnormal fatigability. In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health.

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Sex differences in oxidative stress after eccentric and concentric exercise

Cited by 14 publications

References 37 publications

Anaerobic Exercise-Induced Activation of Antioxidant Enzymes in the Blood of Women and Men

Anaerobic Exercise-Induced Activation of Antioxidant Enzymes in the Blood of Women and Men

The Effects of Eccentric Exercise on Muscle Damage and Blood Redox Status in Men and Women

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

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