Sex differences in shock motivated behaviors, activity, and discrimination learning of northern grasshopper mice (Onychomys leucogaster)

Kemble, Ernest D.; Enger, John M.

doi:10.1016/0031-9384(84)90250-6

Cited by 10 publications

(4 citation statements)

References 34 publications

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“…Only a modicum of studies has examined sex-related avoidance learning abilities in mice. Lamberty and Gower (1988) report no sex differences in passive avoidance retention in NMRI mice, whereas Kemble and Enger (1984) report that in northern grasshopper mice, females are superior to males in passive avoidance. As such, our findings support the former, but not the latter study.…”

Section: Discussionmentioning

confidence: 97%

“…Retention of the task is tested 24 hr after acquisition. Previous studies, in other mouse strains, show inconsistent results for retention of a passive avoidance task (Lamberty & Gower, 1988;Kemble & Enger, 1984). The second aim of Experiment 3 was to examine if there were any sex differences in 24-hr retention of a passive avoidance paradigm.…”

Section: Experiments 3: Spontaneous Activity and Retention Measuresmentioning

confidence: 98%

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Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Berger-Sweeney¹,

Arnold²,

Gabeau³

et al. 1995

Behavioral Neuroscience

100

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Sexual dimorphism in spatial and cued navigation using the Morris water maze was examined in C57BL/6 mice both with and without administration of scopolamine, a cholinergic blocker. In Exp. 1, female and male mice learned to perform first a spatial, then a cued, navigation task. Both performed a spatial task similarly; males, however, performed a cued task better than females. In Exp. 2, the sequence of navigation testing was reversed. Both performed similarly on a cued task; however, males performed a spatial task better than females. In both experiments, females were more sensitive than males to the effects of scopolamine. No significant confounding sex differences were found in either spontaneous activity or passive avoidance retention. These data indicate that sex differences in spatial and cued tasks are dependent on the sequence of task presentation and implicate a role for the cholinergic system in these differences.

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Section: Discussionmentioning

confidence: 97%

Section: Experiments 3: Spontaneous Activity and Retention Measuresmentioning

confidence: 98%

Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Berger-Sweeney¹,

Arnold²,

Gabeau³

et al. 1995

Behavioral Neuroscience

100

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show abstract

“…In females, radiation-induced cognitive injury was associated with increased CD68 levels, while in males, radiation-induced cognitive injury was associated with reduced CD68 levels. These sex-dependent effects of rapid, sequential three-beam irradiation on cortical BDNF and CD68 levels suggest that distinct pathways might be involved in cognitive injury in females and males (Gray, 1971; Beatty et al., 1973; Gray and Lalljee, 1974; Patsch et al., 1980; Kemble and Enger, 1984; Lipa and Kavaliers, 1990; Akinci and Johnston, 1993; Maren et al., 1994; Klein and Flanagan, 2016). Increased efforts are warranted to use unbiased approaches to determine altered pathways in females and males that might underlie the potential effects of the complex radiation fields in deep space for each sex.…”

Section: Discussionmentioning

confidence: 99%

Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice

et al. 2019

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The radiation environment in deep space includes the galactic cosmic radiation with different proportions of all naturally occurring ions from protons to uranium. Most experimental animal studies for assessing the biological effects of charged particles have involved acute dose delivery for single ions and/or fractionated exposure protocols. Here, we assessed the behavioral and cognitive performance of female and male C57BL/6J × DBA2/J F1 (B6D2F1) mice 2 months following rapidly delivered, sequential irradiation with protons (1 GeV, 60%), 16O (250 MeV/n, 20%), and 28Si (263 MeV/n, 20%) at 0, 25, 50, or 200 cGy at 4–6 months of age. Cortical BDNF, CD68, and MAP-2 levels were analyzed 3 months after irradiation or sham irradiation. During the dark period, male mice irradiated with 50 cGy showed higher activity levels in the home cage than sham-irradiated mice. Mice irradiated with 50 cGy also showed increased depressive behavior in the forced swim test. When cognitive performance was assessed, sham-irradiated mice of both sexes and mice irradiated with 25 cGy showed normal responses to object recognition and novel object exploration. However, object recognition was impaired in female and male mice irradiated with 50 or 200 cGy. For cortical levels of the neurotrophic factor BDNF and the marker of microglial activation CD68, there were sex × radiation interactions. In females, but not males, there were increased CD68 levels following irradiation. In males, but not females, there were reduced BDNF levels following irradiation. A significant positive correlation between BDNF and CD68 levels was observed, suggesting a role for activated microglia in the alterations in BDNF levels. Finally, sequential beam irradiation impacted the diversity and composition of the gut microbiome. These included dose-dependent impacts and alterations to the relative abundance of several gut genera, such as Butyricicoccus and Lachnospiraceae. Thus, exposure to rapidly delivered sequential proton, 16O ion, and 28Si ion irradiation significantly affects behavioral and cognitive performance, cortical levels of CD68 and BDNF in a sex-dependent fashion, and the gut microbiome.

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“…These have included studies on predatory behavior (McCarty et al, 1976); sex differences in behavior, activity, and discrimination learning (Kemble and Enger, 1984); and drug effects on aggression (Cole and Wolf, 1970). These have included studies on predatory behavior (McCarty et al, 1976); sex differences in behavior, activity, and discrimination learning (Kemble and Enger, 1984); and drug effects on aggression (Cole and Wolf, 1970).…”

Section: Use In Researchmentioning

confidence: 99%

Biology and Diseases of Other Rodents

Donnelly

Bergin

Ihrig

2015

Laboratory Animal Medicine

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Sex differences in shock motivated behaviors, activity, and discrimination learning of northern grasshopper mice (Onychomys leucogaster)

Cited by 10 publications

References 34 publications

Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice

Biology and Diseases of Other Rodents

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