Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption of<i>tangerine</i>tomatoes

Kopec, Rachel; Schick, Jonathan; Tober, Kathleen L.; Riedl, Ken M.; Francis, David M.; Young, Gregory S.; Schwartz, Steven J.; Oberyszyn, Tatiana M.

doi:10.1002/mnfr.201500317

Cited by 17 publications

(18 citation statements)

References 56 publications

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“…This held true even in mice not exposed to UV denoting that there are fundamental differences in the physiology of skin between the sexes. There was no significant differences in skin fold thickness between the control and tomato diets for either sex after exposure to UV, consistent with previous reports from our group (data not shown) 14 .…”

Section: Resultssupporting

confidence: 93%

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

Cooperstone

Tober

Riedl

et al. 2017

Sci Rep

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Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11–20, mice (n = 120) were exposed to 2240 J/m2 UV-B light, 3x/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73 ± 0.50, P = 0.015) or pooled tomato diets (2.03 ± 0.45, P = 0.017) compared to controls (4.04 ± 0.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.

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Section: Resultssupporting

confidence: 93%

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

Cooperstone

Tober

Riedl

et al. 2017

Sci Rep

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“…Goralczyk and Wertz [11] identified some major mechanisms, among which inhibition of lipid peroxidation, inhibition of UVA-induced expression of heme oxygenase 1, prevention of mitochondrial DNA mutations, inhibition of metalloproteases and photoimmune modulation. Recent experiments in hairless mice subjected to UVB radiation indicated that tangerine tomato carotenoids may exert beneficial effects by attenuating DNA-damage and inflammation, with interesting differences between males and females [180]. Noticeably, new possible mechanisms are hypothesized thanks to the use of omics technologies for the study of changes in gene expressions associated to exposure to carotenoids.…”

Section: Carotenoids and Photoprotectionmentioning

confidence: 99%

Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene

2019

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In this work, the importance of dietary carotenoids in skin health and appearance is comprehensively reviewed and discussed. References are made to their applications in health-promoting and nutricosmetic products and the important public health implications that can be derived. Attention is focused on the colourless UV radiation (UVR)-absorbing dietary carotenoids phytoene and phytofluene, which are attracting increased interest in food science and technology, nutrition, health and cosmetics. These compounds are major dietary carotenoids, readily bioavailable, and have been shown to be involved in several health-promoting actions, as pinpointed in recent reviews. The growing evidence that these unique UVR-absorbing carotenoids with distinctive structures, properties (light absorption, susceptibility to oxidation, rigidity, tendency to aggregation, or even fluorescence, in the case of phytofluene) and activities can be beneficial in these contexts is highlighted. Additionally, the recommendation that the levels of these carotenoids are considered in properly assessing skin carotenoid status is made.

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“…The results indicated that the levels of carotenoids in skin and blood were higher in female mice. With respect to the photoprotective mechanism, UVB-induced carotenoids were associated with a reduction in inflammation and CPDs [ 202 ]. In a study by Cooperstone et al, mice were provided with a tomato-containing diet for 35 weeks.…”

Section: Role Of Whole Fruits and Vegetables In Skin Cancer Prevenmentioning

confidence: 99%

An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

et al. 2020

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Human skin is continuously subjected to environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin adopts various molecular mechanisms to maintain homeostasis, excessive and repeated stresses can overwhelm these systems, leading to serious cutaneous damage, including both melanoma and non-melanoma skin cancers. Phytochemicals present in the diet possess the desirable effects of protecting the skin from damaging free radicals as well as other benefits. Dietary phytochemicals appear to be effective in preventing skin cancer and are inexpensive, widely available, and well tolerated. Multiple in vitro and in vivo studies have demonstrated the significant anti-inflammatory, antioxidant, and anti-angiogenic characteristics of dietary phytochemicals against skin malignancy. Moreover, dietary phytochemicals affect multiple important cellular processes including cell cycle, angiogenesis, and metastasis to control skin cancer progression. Herein, we discuss the advantages of key dietary phytochemicals in whole fruits and vegetables, their bioavailability, and underlying molecular mechanisms for preventing skin cancer. Current challenges and future prospects for research are also reviewed. To date, most of the chemoprevention investigations have been conducted preclinically, and additional clinical trials are required to conform and validate the preclinical results in humans.

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Sex differences in skin carotenoid deposition and acute UVB-induced skin damage in SKH-1 hairless mice after consumption oftangerinetomatoes

Cited by 17 publications

References 56 publications

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene

An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

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