Sex differences in the inflammatory response to stroke

Tariq, Muhammad; Lee, Jun-Young; McCullough, Louise D.

doi:10.1007/s00281-022-00969-x

Cited by 22 publications

(10 citation statements)

References 192 publications

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“…Furthermore, stimulating or inhibiting IFNγ signaling had much greater effects on migration in microglia from male mice than females. These results suggest that microglia in male mice may be more primed to migrate in response to injury or inflammatory signals ( 79 – 81 ). For example, microglia from male mice are larger, more branched, display stronger ATP-evoked currents and are enriched with genes and proteins associated with inflammation and chemotaxis ( 41 , 44 – 46 ).…”

Section: Discussionmentioning

confidence: 93%

Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo

Boghozian

Sharma

Narayana

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Although microglia possess the unique ability to migrate, whether mobility is evident in all microglia, is sex dependent, and what molecular mechanisms drive this, is not well understood in the adult brain. Using longitudinal in vivo two-photon imaging of sparsely labeled microglia, we find a relatively small population of microglia (~5%) are mobile under normal conditions. Following injury (microbleed), the fraction of mobile microglia increased in a sex-dependent manner, with male microglia migrating significantly greater distances toward the microbleed relative to their female counterparts. To understand the signaling pathways involved, we interrogated the role of interferon gamma (IFNγ). Our data show that in male mice, stimulating microglia with IFNγ promotes migration whereas inhibiting IFNγ receptor 1 signaling inhibits them. By contrast, female microglia were generally unaffected by these manipulations. These findings highlight the diversity of microglia migratory responses to injury, its dependence on sex and the signaling mechanisms that modulate this behavior.

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Section: Discussionmentioning

confidence: 93%

Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo

Boghozian

Sharma

Narayana

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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“…The copyright holder for this preprint this version posted February 3, 2023. ; https://doi.org/10.1101/2023.02.02.526857 doi: bioRxiv preprint differences in microglia function and gene expression in the context of normal and disease related conditions [70][71][72] . For example, RNA sequencing 41 showed that microglia from male mice were enriched with genes and proteins associated with inflammation and chemotaxis 38,[41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

“…Together, these results suggest that microglia in male mice may be more primed to migrate in response to injury or inflammatory related signals than female mice. In recent years, there has been a greater appreciation for sex differences in microglia function and gene expression in the context of normal and disease related conditions [70][71][72] . For example, RNA sequencing 41 showed that microglia from male mice were enriched with genes and proteins associated with inflammation and chemotaxis 38,[41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Sex and interferon gamma signaling regulate microglia migration in adult mouse cortexin vivo

Boghozian

Sharma

Cheema

et al. 2023

Preprint

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Although microglia possess the unique ability to migrate, whether mobility is evident in all microglia, is sex dependent, and what molecular mechanisms drive this, is poorly understood in the adult brain. Using longitudinal in vivo imaging of sparsely labelled microglia, we find a relatively small population of microglia are mobile under normal conditions. Following injury (microbleed), the population of mobile microglia increased in a sex-dependent manner, with male microglia migrating significantly greater distances towards the microbleed relative to their female counterparts. To understand the signaling pathways involved, we interrogated the role of interferon gamma (IFNγ). Our data show that in male mice, stimulating microglia with IFNγ or inducible microglial specific knockdown of IFNγ receptor 1 stimulates or inhibits migration, respectively, whereas female microglia were generally unaffected. These findings highlight the diversity of microglia migratory responses to injury, its dependence on sex and the signaling mechanisms that modulate this behavior.

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“…Post-stroke depression is a brain disease. In addition to stroke itself, which activates glial cell activation and causes CNS inflammation ( Lubart et al, 2021 ; Rayasam et al, 2022 ; Tariq et al, 2022 ), peripheral inflammatory factors may establish relationship with the CNS after crossing the BBB as well ( Beurel et al, 2020 ). Furthermore, a significant correlation between CNS inflammation and peripheral inflammation is also supported ( Leng et al, 2018 ; Richards et al, 2018 ).…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

et al. 2023

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Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of PSD. Furthermore, stroke can be effectively treated with acupuncture at all stages and it may act as a special microecological regulator by regulating intestinal microbiota as well. In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research.

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Sex differences in the inflammatory response to stroke

Cited by 22 publications

References 192 publications

Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo

Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo

Sex and interferon gamma signaling regulate microglia migration in adult mouse cortexin vivo

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

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