Sex differences in the relationship between maternal fear of pain and children&amp;#39;s conditioned pain modulation

Evans, Subhadra; Seidman, Laura C; Lung, Kirsten C.; Zeltzer, Lonnie K.; Tsao, Jennie C.I.

doi:10.2147/jpr.s43172

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…We can only speculate that parents may be more sensitive to the possible discomfort of the blood draw in girls than in boys; boys are often expected to be braver than girls. Another study found that girls' pain threshold is lower than that of boys, at least for slightly older children compared to the TEDDY children in our study [ 15 ]. This could indicate that the reaction of girls to the blood draw might be stronger than that of the boys and therefore the parents might be more prone to opt out when the child is a girl even when the child is younger.…”

Section: Discussionmentioning

confidence: 38%

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing

Lernmark

Lynch

Baxter³

et al. 2016

Journal of Diabetes Research

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Background. To characterize participant reasons for withdrawing from a diabetes focused longitudinal clinical observational trial (TEDDY) during the first three study years. Methods. 8677 children were recruited into the TEDDY study. At participant withdrawal staff recorded any reason parents provided for withdrawal. Reasons were categorized into (1) family characteristics and (2) protocol reasons. Families who informed staff of their withdrawal were classified as active withdrawals (AW); families without a final contact were considered passive withdrawals (PW). Results. Withdrawal was highest during the first study year (n = 1220). Most families were AW (n = 1549; 73.4%). PW was more common in the United States (n = 1001; 37.8%) and among young mothers (p = 0.001). The most frequent protocol characteristic was blood draw (55%) and the most common family reason was not having enough time (66%). The blood draw was more common among female participants; being too busy was more common among males. Both reasons were associated with study satisfaction. Conclusions. Results suggest that, for families of children genetically at risk for diabetes, procedures that can be painful/frightening should be used with caution. Study procedures must also be considered for the demands placed on participants. Study satisfaction should be regularly assessed as an indicator of risk for withdrawal.

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Section: Discussionmentioning

confidence: 38%

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing

Lernmark

Lynch

Baxter³

et al. 2016

Journal of Diabetes Research

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“…Consistent with previous research, PASS-20 scores were dichotomized via median split (e.g., Evans, Seidman, Lung, Zeltzer, & Tsao, 2013). The Kaplan Meier survival curve represents the probability of maintaining smoking abstinence for a given length of time while considering time in many small intervals (Kaplan & Meier, 1958).…”

Section: Methodsmentioning

confidence: 99%

Pain-related anxiety as a predictor of early lapse and relapse to cigarette smoking.

LaRowe

Langdon

Zvolensky³

et al. 2017

Experimental and Clinical Psychopharmacology

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Although emerging research suggests that pain-related anxiety may play a role in the maintenance of tobacco dependence, no previous work has examined pain-related anxiety as a predictor of smoking cessation outcomes. The goal of the current study was to test the hypothesis that pain-related anxiety would predict early lapse and relapse to cigarette smoking. These data were collected in the context of a primary study examining the role of emotional vulnerabilities in smoking cessation. The current analyses were conducted among a sample of 55 daily cigarette smokers who attempted to quit smoking without using any psychosocial or pharmacological cessation aids. Pain-related anxiety was assessed at baseline using the PASS-20. Early lapse and relapse were assessed using timeline follow-back procedures. Cox regression analyses indicated that pain-related anxiety was a significant predictor of both early smoking lapse and relapse, such that for every one-point increase on the PASS-20, the risk of early lapse increased by 3.7% and the risk of early relapse increased by 3.6%. These effects were evident above and beyond the variance accounted for by tobacco dependence, past four-week pain severity, anxiety sensitivity, and the presence of current Axis I psychopathology. Kaplan-Meier survival analyses further revealed that among early lapsers, greater pain-related anxiety predicted a more rapid trajectory to lapse. Pain-related anxiety was also shown to be a significant predictor of early lapse when the sample was limited to smokers who endorsed past four-week pain. These findings lend empirical support to the notion that pain-related anxiety may contribute to the maintenance of tobacco dependence among smokers who experience varying levels of pain intensity.

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“…The magnitude of CPM was influenced by neither age nor maternal anxiety over pain in both boys and girls. Greater maternal pain anxiety was significantly associated with greater CPM anticipatory anxiety and pain-related fear in girls, but not in boys [24]. …”

Section: Conditioning and Learning Mechanismsmentioning

confidence: 99%

Pain and placebo in pediatrics: A comprehensive review of laboratory and clinical findings

Simmons

Ortiz

Kossowsky

et al. 2014

Pain

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Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, this comprehensive review examines studies related to pain modulation with an emphasis on factors such as age, neural development and pain measures. Psychological mechanisms underlying placebo effects including: 1) verbally-induced expectations; 2) conditioning and learning mechanisms; 3) child-parent-physician interactions are critically discussed. Taken together, research suggests that placebo mechanisms can impact therapeutic outcomes and potentially be exploited clinically to improve clinical outcomes in pediatric population. Recommendations for further investigating the mechanistic bases and harnessing placebo effects for supportive therapeutic applications are given.

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Sex differences in the relationship between maternal fear of pain and children's conditioned pain modulation

Cited by 8 publications

References 33 publications

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing

Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing

Pain-related anxiety as a predictor of early lapse and relapse to cigarette smoking.

Pain and placebo in pediatrics: A comprehensive review of laboratory and clinical findings

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