2007
DOI: 10.1161/hypertensionaha.107.087957
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Sex Differences in the Renal Changes Elicited by Angiotensin II Blockade During the Nephrogenic Period

Abstract: Abstract-The renin-angiotensin system plays an important role in renal development. However, it is unknown whether reduction in angiotensin II effects during the nephrogenic period leads to different renal alterations in males and females during the adult age. The aim of this study was to evaluate whether the role of angiotensin II on renal development is sex dependent and whether there are sex differences in blood pressure, renal hemodynamics, and severity of renal damage during adult life when nephrogenesis … Show more

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Cited by 49 publications
(104 citation statements)
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References 29 publications
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“…Nonetheless a dichotomy emerges later in life with females being less impacted by their suboptimal in utero experience (Loria et al, 2007a;Loria et al, 2007b;Saez et al, 2007;Salazar et al, 2008). The apparent benefit of being female in scenarios such as this are supported by recent work that suggested estrogens confer a protective effect on intrauterine growth restricted females that prevents the development of programmed hypertension (Ojeda et al, 2007a).…”
Section: Sex Steroidsmentioning
confidence: 98%
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“…Nonetheless a dichotomy emerges later in life with females being less impacted by their suboptimal in utero experience (Loria et al, 2007a;Loria et al, 2007b;Saez et al, 2007;Salazar et al, 2008). The apparent benefit of being female in scenarios such as this are supported by recent work that suggested estrogens confer a protective effect on intrauterine growth restricted females that prevents the development of programmed hypertension (Ojeda et al, 2007a).…”
Section: Sex Steroidsmentioning
confidence: 98%
“…These approaches may be in the form of administration of RAS inhibitors (Salazar et al, 2008) or altered sodium diet as described above (Battista et al, 2002). RAS inhibition at the level of the AT 1 receptor is reported to have several sex specific effects that manifest post-partum (Loria et al, 2007b;Saez et al, 2007;Salazar et al, 2008). Saez et al found that AT 1 inhibition reduces nephron number similarly in male and female rats, but the subsequent glomerulosclerosis and interstitial fibrosis are greater in males than in females.…”
Section: Endocrine Disruptionmentioning
confidence: 99%
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“…ДИНАМИКА СОЗРЕВАНИЯ ПЛОДА И НЕФРОГЕНЕЗ У крыс, которые относятся к так называемым незре-лорождающимся млекопитающим, нефрогенез начинает-ся на 12-е сут постконцепционного периода и заканчива-ется к 10-м сут после рождения [26,27], поэтому период, в течение которого внешние воздействия могут оказать неблагоприятный эффект на развитие почек, захватыва-ет не только внутриутробное развитие, но и начальную часть постнатального [28]. Вследствие этого данные, полученные на грызунах, могут быть экстраполированы на человека с большой осторожностью.…”
Section: феномен внутриутробного программирования патологииunclassified