Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats

Tan, Sisi; Xue, Song; Behnood‐Rod, Azin; Chellian, Ranjithkumar; Wilson, Ryann; Knight, Parker; Panunzio, Stefany; Lyons, Hannah; Febo, Marcelo; Bruijnzeel, Adrie W.

doi:10.1016/j.neuropharm.2019.107756

Cited by 29 publications

(19 citation statements)

References 69 publications

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“…Nicotine withdrawal in adult male and female SD and Wistar rats leads to somatic withdrawal signs (Hamilton et al, 2009; Torres et al, 2013). In our recent study, removal of minipumps led to greater anhedonia in male rats (6–96 h after withdrawal) than in female rats (only at 6 h after withdrawal) (Tan et al, 2019). In addition, low doses of mecamylamine produced greater anhedonia in males than in females and precipitated somatic withdrawal signs were detected in males but not in females (Tan et al, 2019).…”

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 91%

“…In our recent study, removal of minipumps led to greater anhedonia in male rats (6–96 h after withdrawal) than in female rats (only at 6 h after withdrawal) (Tan et al, 2019). In addition, low doses of mecamylamine produced greater anhedonia in males than in females and precipitated somatic withdrawal signs were detected in males but not in females (Tan et al, 2019). In contrast, mecamylamine-precipitated somatic withdrawal signs are detected in male and female rats exposed to nicotine via minipumps.…”

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 91%

“…Cessation of nicotine exposure in rats leads to somatic withdrawal signs such as eye blinks, gasps, writhes, head shake, ptosis, teeth chattering, and yawns. In order to prevent a high level of activity, the mice and rats need to be habituated to the observation chambers before testing for somatic withdrawal signs (Ponzoni et al, 2015; Stoker et al, 2008; Tan et al, 2019). Environmental conditions such as light intensity affect the number of somatic withdrawal signs (Hamilton et al, 2009).…”

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 99%

“…Furthermore, mecamylamine-precipitated anxiety-like behavior is observed only in female rats and not in male rats (Correa et al, 2019). However, anxiety-like behavior was not observed in male and female rats after removal of the minipumps (spontaneous withdrawal) (Tan et al, 2019). On the other hand, in adult mice, spontaneous and mecamylamine-precipitated nicotine withdrawal leads to anxiety-like behavior, hyperalgesia, and increased locomotor activity in males but not in females (Kota et al, 2007, 2008).…”

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 99%

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Rodent models for nicotine withdrawal

et al. 2021

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Background: Animal models are critical to improve our understanding of the neuronal mechanisms underlying nicotine withdrawal. Nicotine dependence in rodents can be established by repeated nicotine injections, chronic nicotine infusion via osmotic minipumps, oral nicotine intake, tobacco smoke exposure, nicotine vapor exposure, and e-cigarette aerosol exposure. The time course of nicotine withdrawal symptoms associated with these methods has not been reviewed in the literature. Aim: The goal of this review is to discuss nicotine withdrawal symptoms associated with the cessation of nicotine, tobacco smoke, nicotine vapor, and e-cigarette aerosol exposure in rats and mice. Furthermore, age and sex differences in nicotine withdrawal symptoms are reviewed. Results: Cessation of nicotine, tobacco smoke, nicotine vapor, and e-cigarette aerosol exposure leads to nicotine withdrawal symptoms such as somatic withdrawal signs, changes in locomotor activity, anxiety- and depressive-like behavior, learning and memory deficits, attention deficits, hyperalgesia, and dysphoria. These withdrawal symptoms are most pronounced within the first week after cessation of nicotine exposure. Anxiety- and depressive-like behavior, and deficits in learning and memory may persist for several months. Adolescent (4–6 weeks old) rats and mice display fewer nicotine withdrawal symptoms than adults (>8 weeks old). In adult rats and mice, females show fewer nicotine withdrawal symptoms than males. The smoking cessation drugs bupropion and varenicline reduce nicotine withdrawal symptoms in rodents. Conclusion: The nicotine withdrawal symptoms that are observed in rodents are similar to those observed in humans. Tobacco smoke and e-cigarette aerosol contain chemicals and added flavors that enhance the reinforcing properties of nicotine. Therefore, more valid animal models of tobacco and e-cigarette use need to be developed by using tobacco smoke and e-cigarette aerosol exposure methods to induce dependence.

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Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 91%

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 91%

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 99%

Section: Animal Models Of Nicotine Withdrawal Symptomsmentioning

confidence: 99%

See 2 more Smart Citations

Rodent models for nicotine withdrawal

et al. 2021

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“…Such procedures of precipitated nicotine withdrawal induce somatic withdrawal symptoms and negative affect. Studies of somatic withdrawal signs are mixed, with some reporting no sex differences ( Correa et al, 2019 ) and others showing male rats with higher somatic withdrawal scores compared with females ( Tan et al, 2019 ). However, female rodents consistently show heightened sensitivity to the negative affect aspect of nicotine withdrawal.…”

Section: Sex Differences In Nicotine Behaviorsmentioning

confidence: 99%

Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors

Moen

Lee

2021

Front. Neurosci.

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Alcohol and nicotine are the two most widely used and misused drugs around the world, and co-consumption of both substances is highly prevalent. Multiple lines of evidence show a profound effect of sex in many aspects of alcohol and nicotine reward, with women having more difficulty quitting smoking and showing a faster progression toward developing alcohol use disorder compared with men. Both alcohol and nicotine require neuronal nicotinic acetylcholine receptors (nAChRs) to elicit rewarding effects within the mesolimbic system, representing a shared molecular pathway that likely contributes to the frequent comorbidity of alcohol and nicotine dependence. However, the majority of preclinical studies on the mechanisms of alcohol and nicotine reward behaviors utilize only male rodents, and thus our understanding of alcohol and nicotine neuropharmacology relies heavily on male data. As preclinical research informs the development and refinement of therapies to help patients reduce drug consumption, it is critical to understand the way biological sex and sex hormones influence the rewarding properties of alcohol and nicotine. In this review, we summarize what is known about sex differences in rodent models of alcohol and nicotine reward behaviors with a focus on neuronal nAChRs, highlighting exciting areas for future research. Additionally, we discuss the way circulating sex hormones may interact with neuronal nAChRs to influence reward-related behavior.

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Striatal Cholinergic Interneurons Control Physical Nicotine Withdrawal via Muscarinic Receptor Signaling

Kim,

Woo

et al. 2024

Advanced Science

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Striatal cholinergic interneurons (ChIs) provide acetylcholine tone to the striatum and govern motor functions. Nicotine withdrawal elicits physical symptoms that dysregulate motor behavior. Here, the role of striatal ChIs in physical nicotine withdrawal is investigated. Mice under RNAi‐dependent genetic inhibition of striatal ChIs (ChIGI) by suppressing the sodium channel subunit NaV1.1, lessening action potential generation and activity‐dependent acetylcholine release is first generated. ChIGI markedly reduced the somatic signs of nicotine withdrawal without affecting other nicotine‐dependent or striatum‐associated behaviors. Multielectrode array (MEA) recording revealed that ChIGI reversed ex vivo nicotine‐induced alterations in the number of neural population spikes in the dorsal striatum. Notably, the drug repurposing strategy revealed that a clinically‐approved antimuscarinic drug, procyclidine, fully mimicked the therapeutic electrophysiological effects of ChIGI. Furthermore, both ChIGI and procyclidine prevented the nicotine withdrawal‐induced reduction in striatal dopamine release in vivo. Lastly, therapeutic intervention with procyclidine dose‐dependently diminished the physical signs of nicotine withdrawal. The data demonstrated that the striatal ChIs are a critical substrate of physical nicotine withdrawal and that muscarinic antagonism holds therapeutic potential against nicotine withdrawal.

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Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats

Cited by 29 publications

References 69 publications

Rodent models for nicotine withdrawal

Rodent models for nicotine withdrawal

Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors

Striatal Cholinergic Interneurons Control Physical Nicotine Withdrawal via Muscarinic Receptor Signaling

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