Sex hormone–binding globulin and lipid profile in pubertal children

Garcés, Cármen; Oya, Iría de; Lasunción, Miguel A.; López-Simón, Laura; Cano, Beatriz; Oya, Manuel de

doi:10.1016/j.metabol.2009.06.033

Cited by 39 publications

(34 citation statements)

References 29 publications

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“…Decreased SHBG is associated with the increase of adrenal androgens during puberty [25], which in turn can stimulate bone maturation by locally increasing oestrogen levels via expression of aromatase [26]. In contrast, a trend toward a positive association between SHBG SDS and BA SDS was found in regression analysis in the female subgroup, possibly reflecting increased gonadal oestrogen production during puberty, stimulating SHBG in girls.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Advanced Bone Age in Childhood Obesity

et al. 2017

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Background: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. Method: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obese children. A multivariate analysis was performed to investigate which parameters were independently predictive of BA SDS. Results: In this cohort (n = 101; mean age 10.9 years; mean BA 11.8 years; mean BMI SDS 3.3), BMI SDS was significantly correlated to BA SDS (r = 0.55, p < 0.001). In a regression analysis in the total cohort (B = 0.27, p < 0.001) as well as in females (B = 0.34, p = 0.042), males (B = 0.31, p = 0.006), and pubertal children (B = 0.32, p = 0.046), dehydroepiandrosterone sulphate (DHEAS) showed a positive, independent association with BA SDS. No association with indicators of insulin secretion was found. Conclusion: BMI SDS is highly correlated to BA SDS in obese children. Increased DHEAS has a central role in advanced BA in obese children.

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Section: Discussionmentioning

confidence: 99%

Determinants of Advanced Bone Age in Childhood Obesity

et al. 2017

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“…These differences are often related to protective effects by sex-specific hormone levels [50]. As the larger part of the study population was in or past puberty, early hormonal effects in girls could also play a role [51].…”

Section: Discussionmentioning

confidence: 99%

Infectious diseases are associated with carotid intima media thickness in adolescence

et al. 2015

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“…Though the samples were selected from a population-based study and were a representative sample of Iranian children, the results would be more conclusive in a larger sample size. Moreover, we did not evaluate the sexual maturity of the participants, the impact of sexual maturation on children's lipid levels having been demonstrated in previous studies [43,44].…”

Section: Discussionmentioning

confidence: 99%

Relationship of lipid regulatory gene polymorphisms and dyslipidemia in a pediatric population: the CASPIAN III study

et al. 2018

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Objective In this study, we aimed to assess the association between four variants in three genes whose association has been reported in adults but not in children. We evaluated the relationship of the GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) polymorphisms with serum lipid levels in Iranian children. Design This cross-sectional study was conducted in a subpopulation of the CASPIAN III study. During this study, 550 frozen whole blood samples were selected randomly. Using the recorded information of selected cases, those with and without abnormal lipid levels were determined. Allelic and genotypic frequencies of GCKR (rs780094), GCKR (rs1260333), MLXIPL (rs3812316), and FADS (rs174547) polymorphisms were determined and compared in dyslipidemic and normal children. The association between the studied polymorphisms and lipid profiles was determined using logistic regression analysis. Results Prevalence of hypercholesterolemia, hypertriglyceridemia, high low-density lipoprotein cholesterol (LDL-C), and low high-density lipoprotein cholesterol (HDL-C) were 24.9, 34.5, 19.0, and 40.7%, respectively. Significant correlations were found between GCKR (rs780094) and GCKR (rs1260333) polymorphisms and cholesterol and triglyceride levels, between FADS (rs174547) polymorphism and level of triglyceride, and also between MLXIPL (rs3812316) and levels of HDL-C. Conclusions The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population. These results could provide baseline information on as well as further insight into the genetic makeup of lipid profiles in Iranian children, which could be used for preventative strategies.

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Sex hormone–binding globulin and lipid profile in pubertal children

Cited by 39 publications

References 29 publications

Determinants of Advanced Bone Age in Childhood Obesity

Determinants of Advanced Bone Age in Childhood Obesity

Infectious diseases are associated with carotid intima media thickness in adolescence

Relationship of lipid regulatory gene polymorphisms and dyslipidemia in a pediatric population: the CASPIAN III study

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