Sex Hormone Binding Globulin Gene Polymorphism and Risk of Type2 Diabetes Mellitus in Egyptian Men

Tarhouny, El; Ss, Zakaria; Am, Abdu-Allah; Km, Hadhoud; Mi, Mahmoud; Nozha, Al

doi:10.7727/wimj.2014.088

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…It has been reported that SHBG down-regulation increased the estradiol to regulate glucose metabolism among Egyptian T2DM cases. The rs6257 allele carriers were correlated with SHBG down-regulation, while the SHBG up-regulation was observed in rs6259 allele carriers [ 134 ].…”

Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

et al. 2022

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Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and organs, including eyes, kidneys, and cardiovascular system. According to the World Health Organization, diabetes prevalence is 8.8% globally among whom about 90% of cases are type 2 diabetes. There are not any significant clinical manifestations in the primary stages of diabetes. Therefore, screening can be an efficient way to reduce the diabetic complications. Over the recent decades, the prevalence of diabetes has increased alarmingly among the Middle East population, which has imposed exorbitant costs on the health care system in this region. Given that the genetic changes are among the important risk factors associated with predisposing people to diabetes, we examined the role of single-nucleotide polymorphisms (SNPs) in the pathogenesis of diabetes among Middle East population. In the present review, we assessed the molecular pathology of diabetes in the Middle East population that paves the way for introducing an efficient SNP-based diagnostic panel for diabetes screening among the Middle East population. Since, the Middle East has a population of 370 million people; the current review can be a reliable model for the introduction of SNP-based diagnostic panels in other populations and countries around the world.

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Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

et al. 2022

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Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study

et al. 2019

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Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men

Basualto-Alarcón

García‐Rivas

Troncoso

et al. 2021

International Journal of Endocrinology

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In men, 70% of circulating testosterone binds with high affinity to plasma sex hormone binding globulin (SHBG), which determines its bioavailability in their target cells. In recent years, a growing body of evidence has shown that circulating SHBG not only is a passive carrier for steroid hormones but also actively regulates testosterone signaling through putative plasma membrane receptors and by local expression of androgen-binding proteins apparently to reach local elevated testosterone concentrations in specific androgen target tissues. Circulating SHBG levels are influenced by metabolic and hormonal factors, and they are reduced in obesity and insulin resistance, suggesting that SHBG may have a broader clinical utility in assessing the risk for cardiovascular diseases. Importantly, plasma SHBG levels are strongly correlated with testosterone concentrations, and in men, low testosterone levels are associated with an adverse cardiometabolic profile. Although obesity and insulin resistance are associated with an increased incidence of cardiovascular disease, whether they lead to abnormal expression of circulating SHBG or its interaction with androgen signaling remains to be elucidated. SHBG is produced mainly in the liver, but it can also be expressed in several tissues including the brain, fat tissue, and myocardium. Expression of SHBG is controlled by peroxisome proliferator-activated receptor γ (PPARγ) and AMP-activated protein kinase (AMPK). AMPK/PPAR interaction is critical to regulate hepatocyte nuclear factor-4 (HNF4), a prerequisite for SHBG upregulation. In cardiomyocytes, testosterone activates AMPK and PPARs. Therefore, the description of local expression of cardiac SHBG and its circulating levels may shed new light to explain physiological and adverse cardiometabolic roles of androgens in different tissues. According to emerging clinical evidence, here, we will discuss the potential mechanisms with cardioprotective effects and SHBG levels to be used as an early metabolic and cardiovascular biomarker in men.

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Sex Hormone Binding Globulin Gene Polymorphism and Risk of Type2 Diabetes Mellitus in Egyptian Men

Abstract: ABSTRACT

Cited by 4 publications

References 28 publications

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

Association of rs6259 polymorphism with SHBG levels and Poly Cystic Ovary Syndrome in Indian population: a case control study

Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men

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