Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents#

Oya, Iría de; Schoppen, Stefanie; Lasunción, Miguel A.; López-Simón, Laura; Riestra, Pía; Oya, Manuel de; Garcés, Cármen

doi:10.1111/j.1399-5448.2009.00559.x

Cited by 20 publications

(15 citation statements)

References 33 publications

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“…We found a negative relationship between SHBG and BMI. The same correlation was described in adolescents with simple obesity, and it was explained by the obesity-related hyperinsulinemia and hepatic insulin resistance, leading to a deficiency of SHBG hepatic production (42). In our study group, mean SHBG levels were not significantly different from those in the control group, and a direct correlation between SHBG levels and T1D duration was evident.…”

Section: Discussionsupporting

confidence: 78%

Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Bizzarri

Benevento

Ravà

et al. 2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 78%

Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Bizzarri

Benevento

Ravà

et al. 2011

Fertility and Sterility

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“…In children, SHBG levels have proven to correlate negatively with obesity and to correlate positively with insulin sensitivity (8,9). Furthermore, SHBG has been shown to correlate negatively with markers of the metabolic syndrome as dyslipidaemia and hypertension (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children

Birkebæk

Lange²,

Holland-Fischer³

et al. 2010

European Journal of Endocrinology

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Objective: Obesity in men is associated with reduced insulin sensitivity and hypoandrogenism, while obesity in women is associated with reduced insulin sensitivity and hyperandrogenism. In children, the effect of obesity and weight reduction on the hypothalamo-pituitary-gonadal axis is rarely investigated. The aim of the present study was to investigate the effect of weight reduction in obese Caucasian children on insulin sensitivity, sex hormone-binding globulin (SHBG), DHEAS and the hypothalamo-pituitary-gonadal axis. Methods: One hundred and sixteen (65 females) obese children with a median age of 12.3 (7-15) years were examined before and after a 10-week stay at a weight loss camp. Examination included anthropometry and fasting blood samples measuring plasma glucose, serum insulin, SHBG, DHEAS, testosterone, 17b-oestradiol, FSH and LH. Results: Body mass index (BMI) decreased (P!0.01), insulin sensitivity and SHBG increased (P!0.01), independent of gender and puberty. The changes in insulin sensitivity and the changes in SHBG correlated significantly (P!0.01) independent of gender, puberty and the changes in BMI. Testosterone increased in boys (P!0.01) and tended to decrease in girls (PZ0.05, in girls after menarche (PZ0.03)). FSH increased in boys and girls. LH increased in boys and was unchanged in girls. Conclusions: During weight loss, insulin sensitivity and SHBG increased significantly in obese children, and the changes in insulin sensitivity and the changes in SHBG correlated significantly independent of gender, puberty and the changes in BMI. There was sexual dimorphism in the changes of testosterone, with the changes in boys towards increased virilisation and the changes in girls towards less virilisation.

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“…Additionally, the direction of the relationship between rs1799941 genotype and circulating SHBG levels differed significantly between subjects with and without MetS. Two recently published studies using the same population provide strong evidence that circulating SHBG is involved in the pathogenesis of MetS in children and adolescents [ 17 , 38 ]. Low SHBG level was a significant predictor of insulin resistance, low HDL-C and MetS in children [ 15 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal changes at puberty lead to increased fat mass, and decreased SHBG levels [ 16 ]. Circulating SHBG is the strongest known predictor of MetS in children and adolescents, with lower SHBG levels associating with increased risk [ 15 , 17 ]. Several studies present evidence of genetic variants modulating lipid levels in adult populations [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents

et al. 2015

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BackgroundMetabolic syndrome (MetS) is a complex disorder characterized by coexistence of several cardiometabolic (CM) factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD). The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.MethodsGenetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs), previously shown to modulate lipid or sex hormone binding globulin (SHBG) levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls).ResultsLogistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006). The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012), while in cases there was no association between rs1799941 and SHBG levels (p = 0.963).ConclusionsThe significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.

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Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents#

Abstract: The associations of SHBG with MS and its components, such as abdominal obesity, high BP or insulin levels, are already present in normal adolescents. This may suggest the possibility of using SHBG levels as a biomarker for MS risk in adolescents as well as adults.

Cited by 20 publications

References 33 publications

Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children

SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents

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