Sex Hormone Changes in Morbidly Obese Patients after Vertical Banded Gastroplasty

Bastounis, Elias; Karayiannakis, Anastasios J.; Syrigos, Konstantinos; Zbar, Andrew P.; Makri, G. G.; Alexiou, D

doi:10.1159/000008556

Cited by 117 publications

(74 citation statements)

References 23 publications

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“…Vertical gastroplasty of 19 morbidly obese men caused a significant weight loss, and after 12 months, a significant decrease in estradiol levels and an increase in FSH, total testosterone, and SHBG levels occurred. 27 These observations provide further support for the effects of obesity on SHBG and testosterone.…”

Section: Factors Affecting Shbg Levelssupporting

confidence: 54%

Hypogonadism and diabetes

Betancourt-Albrecht

Cunningham

2003

Int J Impot Res

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Clinicians have been aware of the increased prevalence of low testosterone levels in patients with type II diabetes for several years, but how these two conditions are associated is difficult to determine. Older age and obesity may be factors, as both are associated with type II diabetes and both decrease testosterone levels. Sex hormone-binding globulin (SHBG), the major serum carrier protein for testosterone, also may have an impact. SHBG levels fall with obesity and increase with aging. Some studies indicate lower SHBG levels in type II diabetes. Most of the differences in testosterone levels between diabetic and nondiabetic patients may be due to reduced SHBG, rather than reduced testosterone production. However, free testosterone levels fall with increasing age and obesity, rendering many type II diabetic patients testosterone deficient. Testosterone replacement may improve insulin sensitivity in hypogonadal, overweight men with type II diabetes by altering body composition, but studies are conflicting.

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Section: Factors Affecting Shbg Levelssupporting

confidence: 54%

Hypogonadism and diabetes

Betancourt-Albrecht

Cunningham

2003

Int J Impot Res

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“…(22) and (23)but this disagreed with the study of Omanaet al (24) who reported that the increase in SHBG levels after bariatric surgery, although trending strongly, was not significant. obestatin was suggested to contribute to appetite and body weight regulation by antagonizing the effects of ghrelin.…”

Section: IVcontrasting

confidence: 58%

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Razak¹,

GhaniMBchB²,

Sami³

et al. 2014

IOSRJDMS

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“…With the exception of one case report of unexplained spermatogenic arrest after bariatric surgery-induced weight loss [39], there is a paucity of studies assessing the impact of weight loss on male reproductive success, assisted or unassisted. Obese men showed an overall improved reproductive hormone profile, with an increase in SHBG and testosterone and decrease in estrogen after bariatric surgery induced weight loss [40,41]. Accordingly, our findings provide an additional argument to study the effects of weight reduction in infertile men.…”

Section: Discussionmentioning

confidence: 52%

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Keltz

Zapantis

Jindal

et al. 2010

J Assist Reprod Genet

100

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Purpose To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods Retrospective study of 290 cycles. Results Male body mass index greater than 25.0 kg/m 2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

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Sex Hormone Changes in Morbidly Obese Patients after Vertical Banded Gastroplasty

Cited by 117 publications

References 23 publications

Hypogonadism and diabetes

Hypogonadism and diabetes

Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

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