Sex hormone concentrations in men with angiographically assessed coronary artery disease — Relationship to obesity and body fat distribution

Hauner, Hans; Stangl, Karl; Burger, K; Busch, Ulrich; Blömer, H; Pfeiffer, Ernst-Friedrich

doi:10.1007/bf01649428

Cited by 29 publications

(8 citation statements)

References 29 publications

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“…Of 33 cross-sectional studies, 21 reported lower concentrations of T, BT, and/or DHEA(-S) in patients with CHD than in healthy men (14, 66, 69 -76, 79 -86, 93, 96, 98). In 12 other studies (11,44,67,68,77,78,(87)(88)(89)(90)(91)(92), similar levels of these sex hormones were found in controls and patients with CHD, and one study (68) showed elevated levels of DHEA(-S) in patients. One study (97) reported hyperestrogenemia to be related to thrombotic occlusion of the coronary arteries in MI; the mean serum estradiol level in the men who had had an MI (38.5 Ϯ 8.8 pg/ml) was higher (P ϭ 0.002) than the level in men who had not had an MI (31.9 Ϯ 7.1 pg/ml).…”

Section: Coronary Heart Disease [Angina Pectoris Myocardial Infarctisupporting

confidence: 70%

Endogenous Sex Hormones and Cardiovascular Disease in Men

Muller

Schouw

Thijssen

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

118

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Unlike women, men do not experience an abrupt reduction in endogenous sex hormone production. It has, however, become clear that an age-associated decrease in the levels of (bioactive) sex hormones does occur. Whether endogenous sex hormones have an impact on cardiovascular disease has for many years remained largely unknown, but during the last decade more attention has been drawn to the importance of testosterone, estrogens, and adrenal androgens in etiology, prevention, and treatment of male cardiovascular disease. The purpose of this article is to summarize the evidence currently available on the association between endogenous sex hormones and cardiovascular disease in males. Published studies dealing with the relationship between circulating levels of sex hormones and cardiovascular disease in males were reviewed. The studies reviewed in this article suggest that circulating endogenous sex hormones and estrogens have a neutral or beneficial effect on cardiovascular disease in men.

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Section: Coronary Heart Disease [Angina Pectoris Myocardial Infarctisupporting

confidence: 70%

Endogenous Sex Hormones and Cardiovascular Disease in Men

Muller

Schouw

Thijssen

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

118

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“…Yang found that 2D:4D ratios, measures of masculine characteristics, and salivary testosterone showed no significant associations with one another in both male and female 18. Hauner detected no relationship between sex hormone concentrations and coronary artery disease assessed by angiography in men 38.…”

Section: Discussionmentioning

confidence: 96%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

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Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

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“…In both men and women, elevated DHEA-S levels were associated with retarded progression of atherosclerosis measured by coronary artery angiography (113), ultrasound carotid wall thickness (117) and pulse wave velocity aorta calcification (114). On the other hand, other groups did not confirm these findings using coronary angiography in two male samples (119,120). Retrospective studies have examined whether myocardial infarction survivors were characterized by reduced DHEA-S levels compared with healthy controls (115,116,118).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Tchernof

Labrie

2004

European Journal of Endocrinology

153

100

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The age-related decline in serum dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) has suggested that a relative deficiency of these steroids may be causally related to the development of chronic diseases generally associated with aging, including insulin resistance, obesity, cardiovascular disease, cancer, reductions of the immune defense, depression and a general deterioration in the sensation of well-being. The numerous studies which have focused on the link between DHEA and cardiovascular disease have generally been inconsistent, generating much debate and controversy on this issue. The present article is an analysis of studies on the relationship between endogenous DHEA or DHEA-S, obesity and cardiovascular disease risk, as well as DHEA treatment studies. Elevated plasma levels of free DHEA are associated with reduced obesity in both men and women, and with smaller abdominal body fat accumulations in men. However, contradictory results have been reported regarding the relationships between the sulfate ester DHEA-S and adiposity. Age differences in the populations studied may have been a confounding factor in these associations. On the other hand, DHEA-S level is not a predictor of cardiovascular disease endpoints in women, and appears to be a relatively weak one in men. DHEA intervention studies suggest that the effects of DHEA on serum lipids are, at best, modest or non-significant. The uncertainty as to whether endogenous and exogenous DHEA should be considered cardioprotective is related to discrepancies in the literature on this topic. Several studies may have been plagued by methodological problems such as low power, unreliable analytical methods, confounding factors or other differences in the populations studied. As a consequence, the original reports demonstrating dramatic effects of either endogenous or exogenous DHEA on cardiovascular disease risk have never been replicated. We propose that the effects of DHEA on cardiovascular disease risk (either favorable or unfavorable) should be considered to be much more modest than previously believed.

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Sex hormone concentrations in men with angiographically assessed coronary artery disease — Relationship to obesity and body fat distribution

Cited by 29 publications

References 29 publications

Endogenous Sex Hormones and Cardiovascular Disease in Men

Endogenous Sex Hormones and Cardiovascular Disease in Men

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

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