Sex hormone levels are not associated with progression of renal disease in male patients with T2DM

Feigerlová, Eva; Saulnier, Pierre‐Jean; Gourdy, Pierre; Roussel, Ronan; Gand, Elise; Dardari, D.; Guerci, Bruno; Sosner, P.; Marre, Michel; Zaoui, Philippe; Ragot, Stéphanie; Hadjadj, Samy

doi:10.1016/j.diabet.2016.05.012

Cited by 6 publications

(9 citation statements)

References 32 publications

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“…Sex hormone-binding globulin (SHBG) gene polymorphisms may cause a high risk of T2DM through its impact on testosterone and estradiol levels. A prospective cohort study [11] also demonstrated that higher SHBG and lower calculated free testosterone (cFT) levels were risk factors for all causes of mortality in men with type 2 diabetes mellitus, which could be influenced by the SHBG, a carrier protein of testosterone. Both progesterone and estradiol levels were significantly decreased in diabetes mellitus and IGT patients compared with normal control participants (Figs.…”

Section: Resultsmentioning

confidence: 99%

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A cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients

Wang

Xian²,

Jia³

et al. 2017

Medicine

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Type 2 diabetes mellitus (T2DM) is a long-term metabolic disorder. It is characterized by hyperglycemia, insulin resistance (IR), and relative impairment in insulin secretion. IR plays a major role in the pathogenesis of T2DM. Many previous studies have investigated the relationship between estrogen, androgen, and obesity, but few focused on the relationship between sex hormones, abnormal lipid metabolism, and IR. The goal for the present study was to identify the association of IR with sex hormone, abnormal lipid metabolism in type 2 diabetes, and impaired glucose tolerance (IGT) patients.In total 13,400 participants were analyzed based on the results of the glucose tolerance test. Using a cross-sectional study, we showed the relationship between IR and the level of sex hormones among 3 different glucose tolerance states: normal control people, IGT, and T2DM patients. We also analyzed the relationship between IR and abnormal lipid metabolism.Significantly, luteinizing, progesterone, estradiol, prolactin, and follicle-stimulating hormone levels decreased in T2DM and IGT patients compared with those in normal control people. The association between IR and lipid metabolism disorders in T2DM and IGT patients was also observed.Our clinical findings may offer new insights into understanding the mechanism of metabolic disorders and in new therapeutic methods for the treatment of the prevalence of type 2 diabetes.

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Section: Resultsmentioning

confidence: 99%

“…[5,11] Meanwhile, Baradaran et al [19] found an inverse correlation between serum estradiol concentration and carotid atherosclerosis by using ultrasonography to evaluate the intimamedia thickness (IMT) in men with type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients

Wang

Xian²,

Jia³

et al. 2017

Medicine

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“…Gordon et al suggested that E 2 is a major regulator of VLDL-TG metabolism because E 2 treatment decreased the level of VLDL-TG through accelerated clearance of VLDL-TG in plasma . Wang et al suggested that sex hormone-binding globulin (SHBG) acts upon E 2 levels, and that SHBG polymorphisms might increase T2DM risk because levels of LH, progesterone, E 2 , prolactin, and FSH were lower in T2DM patients and people with impaired glucose tolerance compared with those in healthy people. , …”

Section: Cpf Can Induce Rh Changes and Lead To Metabolic Alterationsmentioning

confidence: 99%

Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones

Ren

et al. 2019

J. Agric. Food Chem.

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Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and detected frequently in fruits, vegetables, as well as in urine and blood in humans. Studies have suggested that CPF can induce metabolic disruption, such as type-2 diabetes mellitus and changed body weight. The main mechanisms are based on oxidative damage, fatty-acid synthesis, and lipid peroxidation. Studies have also shown that CPF can change reproductive hormone (RH) levels. CPF might result in metabolic disorders through altered RH levels. Here, we review the studies showing that CFP causes metabolic disruption. Then, we present the studies showing that CFP changes RH levels. Finally, we discuss a potential pathway of how CPF elicits metabolic disruption.

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“…[10][11][12] Controversially, it was also reported that the T, E2, and sex hormone-binding globulin concentrations were not associated with renal adverse endpoints in diabetic men. 13 In women, the relationship between sex hormones and progression of renal disease has not been properly explored. Recently, Wang and his coworkers have conducted a cross-sectional study in Shanghai, China, which suggested a significant relationship between serum total T, E2, DHEA levels and diabetic macrovascular and microvascular complications among men and postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

“…In men, prior studies showed that lower testosterone (T) and dehydroepiandrosterone (DHEA), with higher estrogen (estradiol, E2) levels are associated with more advanced kidney disease 10‐12 . Controversially, it was also reported that the T, E2, and sex hormone‐binding globulin concentrations were not associated with renal adverse endpoints in diabetic men 13 . In women, the relationship between sex hormones and progression of renal disease has not been properly explored.…”

Section: Introductionmentioning

confidence: 99%

Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: A cross‐sectional study

Zhou

Dong

Liu

et al. 2020

Journal of Diabetes

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Background: Associations between sex hormones and diabetic vascular complications have recently been studied, but the role luteinizing hormone (LH) plays in diabetic kidney disease (DKD) remains uncertain. We aimed to investigate the relationship of LH and DKD in Chinese men and postmenopausal women with type 2 diabetes mellitus (T2DM). Methods: Data were collected from 1775 T2DM men and postmenopausal women in hospital. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to LH quartiles were obtained by multiple logistic regression analysis. Results: LH levels were significantly higher in patients with macroalbuminuria than in those with microalbuminuria, but were not higher in patients with microalbuminuria than in those with normoalbuminuria. Consistently, LH in those with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m 2 were significantly higher than in those with eGFR≥60 mL/min/1.73m 2. The prevalence of macroalbuminuria was obviously increased for subjects of the fourth quartile of LH vs the first to third quartile (20.4% vs 6.2%, 8.0%, 12.2% in men; 25.3% vs 5.5%, 3.8%, 9.3% in postmenopausal women). Multivariate logistic regression demonstrated that subjects within the highest quartile of LH had higher odds of macroalbuminuria than those within the lowest quartile (OR 4.00, 95% CI, 1.87-8.55 for men; OR 9.62, 95% CI, 3.42-27.08 for postmenopausal women), independent of age, diabetes duration, or other metabolic factors. The area under the curve for detecting macroalbuminuria based on LH was 0.662 for men, and 0.767 for postmenopausal women. Conclusion: High LH levels are positively associated with established DKD among Chinese men and postmenopausal women. Elevated LH may be a promising clinical factor for identifying established DKD.

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Sex hormone levels are not associated with progression of renal disease in male patients with T2DM

Cited by 6 publications

References 32 publications

A cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients

A cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients

Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones

Elevated circulating luteinizing hormone levels are associated with diabetic macroalbuminuria in Chinese men and postmenopausal women: A cross‐sectional study

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