Sex Hormone Receptors in the Human Eye

Gupta, Payal; Johar, Kaid; Nagpal, K.K.; Vasavada, Abhay R.

doi:10.1016/j.survophthal.2005.02.005

Cited by 173 publications

(159 citation statements)

References 92 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…1,18 The protective role of oestrogen in cataractogenesis has been well studied in in vivo and in vitro conditions. 5,6,12,15 This study elucidates the quick protective role of 17b-oestradiol against H 2 O 2 -induced oxidative stress in cultured LECs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Gajjar¹,

Patel²,

Alapure³

et al. 2008

Eye

View full text Add to dashboard Cite

Purpose To evaluate the short-term protective effects of oestradiol against damages because of oxidative stress in human lens epithelial cells (LECs). Methods The central zone of human lens epithelium was obtained from the cataract surgery and cultured in MEM culture medium. These cultured LECs were treated with 17b-oestradiol for varying time intervals from 1 to 5 min followed by treatment with H 2 O 2 (5 Â 10 À6 M) in the culture medium. Catalase activity was measured to access the oxidative stress levels. Results LECs exposed to H 2 O 2 (5 Â 10 À6 M) showed a fourfold increase in catalase activity (407.03±89.11 U/lg protein) after 6 h when compared to cultured unexposed LECs (97.124±9.4 U/lg protein). When the cultured LECs were treated with oestradiol (5 Â 10 À8 M) before H 2 O 2 treatment, the increase in catalase activity was inhibited, whereas simultaneous and post-treatments showed no effect. The catalase activity of LECs pretreated with oestradiol for 1, 2, 3 ,and 5 min was 259. 92±18.37, 200.24±14.39, 140.50±19.83, and 110.01±14.66, respectively (Po0.0001). Conclusion Antioxidative enzymes are synthesized in response to the oxidative stress signal. Upon treatment with oestrogen catalase is not synthesized. The pretreatment time of oestrogen required for its antioxidative effect can be seen within 5 min indicating non-genomic mode of action of oestrogen.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1 Various epidemiological studies suggest that women are at a higher risk of developing cataracts than men of the same age group. This risk increases only after menopause, thus leading to the hypothesis that oestrogen is the protective molecule during the reproductive age.…”

Section: Introductionmentioning

confidence: 99%

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Gajjar¹,

Patel²,

Alapure³

et al. 2008

Eye

View full text Add to dashboard Cite

show abstract

“…As discussed, ER has been found in the vascular endothelium of organs other than the gonads including the retina (Gupta et al 2005;Ogueta et al 1999;Suzuma et al 1999). The ligand for either ER or ER can be a form of estrogen or a selective estrogen receptor modulator (SERM).…”

Section: Pericytesmentioning

confidence: 97%

“…17 -hydroxysteroid dehydrogenase type IV is an enzyme which converts E2 to less reactive estrone (Kobayashi et al 1997). It has been proposed its function is to protect the embryonic eye against excessive amounts of E2 (Gupta et al 2005). Messenger RNAs of AR have been found in adult rat retina and uvea, rabbit retina and choroid and human RPE Wickham et al 2000).…”

Section: Pericytesmentioning

confidence: 99%

“…Other human pathologies such as cardiovascular and autoimmune disease have also been linked to sex hormones (Ansar Ahmed et al 1985;Mendelsohn and Karas 2005). Even though sex hormone receptors have been identified in the eye, the role that sex hormones play in the development of eye disease, such as that occurring with diabetes, is less described (Gupta et al 2005). In this chapter, we hope to enlighten the reader about the presence of sex hormone receptors in various eye tissues, present how sex hormones are involved in the mechanisms that control the development of proliferative diabetic retinopathy and offer insight into areas where modulation of these mechanisms could be controlled by blockers of sex hormone receptors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Sex Hormones in Diabetic Retinopathy

Grigsby¹,

Allen²,

Culbert³

et al. 2012

Diabetic Retinopathy

View full text Add to dashboard Cite

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Shree

Choudhary

Bodakhe

2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The ocular renin‐angiotensin system has become an interesting target for ocular diseases because it has been implicated in various ocular diseases such as diabetic retinopathy, glaucoma, age‐related macular degeneration, uveitis, and hypertensive cataracts. In the present study, we explored the effect of topically and orally administered losartan (an angiotensin receptor blocker) on streptozotocin‐induced diabetic cataract in albino rats. Topical treatment with losartan modulated neither the blood glucose level nor the polyol content but oral treatment with losartan decreased both. Topical and oral treatment with losartan significantly increased the antioxidants (glutathione, glutathione peroxidase, superoxide dismutase, and catalase), decreased the lipid peroxidant malondialdehyde, and restored soluble protein, and insoluble protein and various ions (Na+, K+, and Ca2+) in the lens; however, topical treatment had a better effect than oral treatment. These findings demonstrate that topical administration of losartan significantly reduces the risk of cataract formation without affecting either the blood glucose level or polyol contents.

show abstract

Sex Hormone Receptors in the Human Eye

Cited by 173 publications

References 92 publications

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

Rapid action of oestradiol against hydrogen peroxide-induced oxidative stress in cataractous lens epithelium: an in vitro study

The Role of Sex Hormones in Diabetic Retinopathy

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

Contact Info

Product

Resources

About