Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

Amure, B. O.; Omole, A. A.

doi:10.1136/gut.11.8.641

Cited by 20 publications

(19 citation statements)

References 25 publications

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“…Similarly, P-adrenergic stimulation reduces immunologically induced histamine release from sensitized basophils and lung tissue (14,16,17). In contrast, the cholinergic agonist carbachol enhances lysosomal enzyme release from leukocytes, augments histamine and SRS-A release from lung fragments (18,22), evokes secretion of lysosomal acid hydrolases and catecholamines from the bovine adrenal gland (40), and induces gastric secretion (41) and mucin secretion from submaxillary gland (42).…”

Section: Methodsmentioning

confidence: 99%

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

Zurier¹,

Weissmann²,

Hoffstein³

et al. 1974

J. Clin. Invest.

539

182

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A B S T R A C T Selective release of inflammatory ma-terials from leukocyte lysosomes is reduced by compounds which increase cyclic 3',5'-adenosine monophosphate (cAMP) levels in suspensions of human leukocytes and is augmented by agents which increase cyclic 3',5'-guanosine monophosphate (cGMP) levels in these cell suspensions. Lysosomal enzymes are released in the absence of phagocytosis when cytochalasin B (5 ,ug/ml) converts polymorphonuclear leukocytes (PMN) to secretory cells: lysosomes merge directly with the plasma membrane upon encounter of PMN with zymosan, and cells selectively extrude substantial proportions of lysosomal, but not cytoplasmic enzymes. P-Adrenergic stimulation of human leukocytes produced a dose-related reduction in P-glucuronidase release (blocked by 10' M propranolol) whereas a-adrenergic stimulation (phenylephrine plus propranolol) was ineffective. In contrast, the cholinergic agonist carbamylcholine chloride enhanced enzyme secretion, an effect blocked by 1 0' M atropine. Incubation of cells with exogenous cAMP or with agents that increase endogenous cAMP levels (prostaglandin E1, histamine, isoproterenol, and cholera enterotoxin) reduced extrusion of lysosomal enzymes; in contrast, exogenous cGMP and carbamylcholine chloride (which increases endogenous cGMP levels), increased fi-glucuronidase release. Whereas colchicine (5 X 10-' M), a drug which impairs microtubule integrity, reduced selective enzyme release, deuterium oxide,

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Section: Methodsmentioning

confidence: 99%

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

Zurier¹,

Weissmann²,

Hoffstein³

et al. 1974

J. Clin. Invest.

539

182

View full text Add to dashboard Cite

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“…Oestrogens exert an anorectic effect through increased production of serotonin in the CNS and cause increased satiety centre activity via cholecystokinin receptors [24]. An inhibitory effect of oestrogen on gastric motility [25], secretion [26], and stimulation of duodenal bicarbonate secretion are also possible.…”

Section: Rycina 5 Korelacja Między Wydalaniem 6-sulfatoksymelatoninymentioning

confidence: 99%

Wydzielanie serotoniny i melatoniny u kobiet po menopauzie z zaburzeniami odżywiania

Chojnacki

Walecka-Kapica

Błońska

et al. 2016

Endokrynologia Polska

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Introduction: Postmenopausal women manifest emotional disorders associated with an increase in appetite. The aim of the study was to assess the serotonin and melatonin secretion and metabolism in postmenopausal women in relation to eating disorders. Material and methods: Sixty postmenopausal women and 30 women without hormonal disturbances were enrolled into the study and divided into three groups: group I (control) -women without menstrual disorders, group II -postmenopausal women without appetite disorders and change in body weight, and group III -postmenopausal women with increased appetite and weight gain. Serum melatonin, serotonin, urinary 6-sulfatoxymelatonin (aMT6s), and 5-hydroxyindoleacetic acid (5-HIAA) excretion were measured. Results: Serum serotonin and melatonin levels in groups II and III were lower compared to group I. Urinary 5-HIAA and aMT6s excretion was lower in overweight women. In group III the correlation between the serum level of serotonin, melatonin, and BMI was negative; a high statistical significance was found between BMI and urinary aMT6s excretion.

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“…Similarly, fl-adrenergic stimulation reduces immunologically induced histamine release from sensitized basophils and lung tissue [14,16,17] and insulin secretion from pancreatic fl-cells [30]. In contrast, the cholinergic agonist, carbamylcholine, enhances lysosomal enzyme release from leucocytes, augments histamine and SRS-A release from lung fragments [18,22], evokes secretion of lysosomal acid hydrolases and catecholamines from the bovine adrenal gland [31], and induces gastric secretion [32] and mucin secretion from submaxillary gland [331.…”

Section: Discussionmentioning

confidence: 99%

Leukocytes as secretory organs of inflammation

1973

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Selective release of inflammatory materials from leukocyte lysosomes may be regulated by antagonistic effects of cyclic 3', 5'-adenosine monophosphate (cAMP) and cyclic 3', 5'-guanosine monophosphate (cGMP). Lysosomal enzymes are released in the absence of phagoeytosis when cytochalasin B (5 ~g/ml) converts polymorphonuclear leukocytes (PMN) to secretory cells: lysosomes merge directly with the plasma membrane upon encounter of PiN with zymosan, and cells selectively extrude substantial proportions of lysosomal, but not cytoplasmic enzymes./~-Adrenergic stimulation (> 10-s M isoproterenol or 10-7 M epinephrine) of human leukocytes produced a dose-related reduction in fl-glucurouldase release (blocked by 10 -8 M propranolol) whereas ~-adrenergic stimulation (phenylephrine + propranolol) was ineffective. In contrast, the cholinergic agonist carbamylcholine chloride (> 10-s M) enhanced enzyme secretion, an effect blocked by 10 -6 M atropine. Incubation of cells with exogenous cAMP or with agents that increase endogenous cAMP levels (dibutyryl cAMP, prostaglandin

show abstract

Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

Cited by 20 publications

References 25 publications

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

Wydzielanie serotoniny i melatoniny u kobiet po menopauzie z zaburzeniami odżywiania

Leukocytes as secretory organs of inflammation

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