Sex Hormones and Their Impact on Cardiovascular Health

Jesus, Sasha De; Gianos, Eugenia; McNally, Stephanie Trentacoste; Scantlebury, Dawn C.; Rosen, Stacey E.

doi:10.1016/b978-0-12-819369-3.00029-0

Cited by 6 publications

(2 citation statements)

References 96 publications

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“…Also, sex hormones affect several systems, including the skeletal, immune, and nervous systems [ 2 , 3 ]. Abnormal changes in sex hormones may lead to delayed puberty, polycystic ovary syndrome, increased risk of cardiovascular disease, and other health problems [ 1 , 4 ]. Adolescents may be vulnerable to some volatile chemical products, such as methylbenzene, which may cause changes in sex hormone levels due to the inefficiency of their detoxification systems [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Volatile Organic Compound Exposure and Sex Hormones in Adolescents: The Mediating Role of Serum Albumin

Lian,

Guo,

Wang

et al. 2024

Toxics

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The associations between VOCs and sex hormones in adolescents remain unclear, and the role of serum albumin in these associations deserves to be explored. We conducted cross-sectional analyses using generalized linear models (GLMs), weighted quantile sum (WQS) regression, and mediation analysis, based on data from 584 adolescents from the National Health and Nutrition Examination Survey (NHANES). The GLM analyses revealed that seven kinds of mVOCs potentially affected sex hormone levels. According to the WQS regression results, 2-aminothiazoline-4-carboxylic acid (ATCA) was the major contributor to the significant associations of mixed mVOC exposure with testosterone, estradiol, and free androgen index in males; N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC) was the major contributor to the significant associations of mixed mVOC exposure with sex hormone-binding globulin in males; and N-acetyl-S-(benzyl)-L-cysteine (BMA) was the major contributor to the significant associations of mixed mVOC exposure with the ratio of testosterone to estradiol in females. Moreover, serum albumin could mediate up to 9.2% of the associations between mixed exposure to mVOCs and sex hormones. Our findings could provide a reference for studies on the mechanisms underlying the effects of VOCs on sex hormones in adolescents and emphasize the necessity of reducing exposure to ATCA, AMCC, BMA, and their parent compounds.

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Section: Introductionmentioning

confidence: 99%

Association between Volatile Organic Compound Exposure and Sex Hormones in Adolescents: The Mediating Role of Serum Albumin

Lian,

Guo,

Wang

et al. 2024

Toxics

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“…PCOS is an emerging health problem, therefore correct diagnosis, treatment sources, promotion of healthy lifestyles, and early interventions are required to prevent future morbidities (9).…”

Section: Introductionmentioning

confidence: 99%

Impact of Yoga therapy on hormonal imbalance in women with Polycystic Ovarian Disease

Devi¹,

N²

2023

IJAM

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The current study aims to evaluate the impact of yoga therapy on hormonal imbalance in PCOS affected women. An empirical study was conducted on 25 women having been diagnosed with PCOS condition. The study used pre and post design. Before starting allopathic medication participants were explained about yoga therapy and participants in the study voluntarily agreed to participate in this study without using medication. Written consent was obtained from the participants. Testosterone, Prolactin, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), were selected as dependent variables for this study. Before introducing the yoga therapy intervention, baseline hormonal values were collected through blood tests. All the 25 participants practiced yoga protocol specially designed for PCOS condition, for a duration of 12 weeks. At the end of 12 weeks the participant took the blood test in the laboratory for hormonal levels of PCOS related hormones selected for this study. Baseline data was compared with Post data. The impact of yoga therapy on the hormonal imbalance was statistically analysed through paired t-test. The statistical analysis yielded following t values: Serum Testosterone 21.52 (P <0.001), Serum Prolactin 22.13 (P<0.001), Serum LH 30.10 (P<0.001), and Serum FSH 14.16 (P<0.001). The impact of yoga therapy intervention on hormones related to PCOS condition was found to be significantly positive. The results imply that regular yoga practice can be an effective therapy for women with PCOS, especially for correcting imbalance in hormone levels related to PCOS.

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Gender aspects in cardiooncology

Hohneck

Custodis

Rosenkaimer

et al. 2021

European Journal of Public Health

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Background Cardiooncology is a relatively new subspeciality, investigating the side effects of cytoreductive therapies on the cardiovascular (CV) system. Gender differences are well known in oncological and CV diseases, but are less elucidated in cardiooncological collectives. Methods Five hundred and fifty-one patients (278 male, 273 female) with diagnosed cancer who underwent regular cardiological surveillance were enrolled in the ‘MAnnheim Registry for CardioOncology’ and followed over a median of 41 (95% confidence interval: 40–43) months. Results Female patients were younger at the time of first cancer diagnosis [median 60 (range 50–70) vs. 66 (55–75), P = 0.0004], while the most common tumour was breast cancer (49.8%). Hyperlipidaemia was more often present in female patients (37% vs. 25%, P = 0.001). Male patients had a higher cancer susceptibility than female patients. They suffered more often from hypertension (51% vs. 67%, P = 0.0002) or diabetes (14% vs. 21%, P = 0.02) and revealed more often vitamin D deficiency [(U/l) median 26.0 (range 17–38) vs. 16 (9–25), P = 0.002] and anaemia [(g/dl) median 11.8 (range 10.4–12.9) vs. 11.7 (9.6–13.6), P = 0.51]. During follow-up, 140 patients died (male 77, female 63; P = 0.21). An increased mortality rate was observed in male patients (11.4% vs. 14%, P = 0.89), with even higher mortality rates of up to 18.9% vs. 7.7% (P = 0.02) considering tumours that can affect both sexes compared. Conclusions Although female patients were younger at the time of first cancer diagnosis, male patients had both higher cancer susceptibility and an increased mortality risk. Concomitant CV diseases were more common in male patients.

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Sex Hormones and Their Impact on Cardiovascular Health

Cited by 6 publications

References 96 publications

Association between Volatile Organic Compound Exposure and Sex Hormones in Adolescents: The Mediating Role of Serum Albumin

Association between Volatile Organic Compound Exposure and Sex Hormones in Adolescents: The Mediating Role of Serum Albumin

Impact of Yoga therapy on hormonal imbalance in women with Polycystic Ovarian Disease

Gender aspects in cardiooncology

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