Sex-related differences in nortriptyline-induced side-effects among depressed patients

Pomara, Nunzio; Shao, Binbin; Choi, Soo‐Hyung; Tun, H.; Suckow, Raymond F.

doi:10.1016/s0278-5846(01)00175-0

Cited by 19 publications

(8 citation statements)

References 24 publications

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“…Men and women may differ in their pharmacokinetic responses to TCAs, in a number of autonomic indices, and in various adrenergic receptor mediated responses. Emerging evidence also suggests that women, relative to men, may have a lower rate of brain serotonin synthesis and a greater sensitivity to the depressant effects of tryptophan depletion (Pomara et al , 2001).…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Drug effects on salivary glands: dry mouth

2003

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Objective: To identify drugs associated with the complaint of dry mouth. Materials and Methods: MEDLINE was searched for papers 1980–2002 using keywords, oral, mouth, salivary, drugs, dry mouth and xerostomia, and relevant secondary references were hand‐searched. Results: Evidence was forthcoming for a number of xerogenic drugs, especially antimuscarinic agents, some sympathomimetic agents, and agents affecting serotonin and noradrenaline uptake, as well as a miscellany of other drugs such as appetite suppressants, protease inhibitors and cytokines. Conclusion: Dry mouth has a variety of possible causes but drugs – especially those with anticholinergic activity against the M3 muscarinic receptor – are the most common cause of reduced salivation.

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Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Drug effects on salivary glands: dry mouth

2003

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“…Decreased levels of TRP was observed in the blood of patients with depression in several clinical trials [ 21 , 22 , 23 ]. Although clinical trials mainly concentrate on supplementing or depriving TRP or its metabolites for the treatment of neuropsychiatric diseases, current preclinical efforts in drug development for these diseases have mainly focused on altering the rheostat of neuroactive metabolites of the kynurenine pathway [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Intake and Metabolism in Older Adults with Mood Disorders

et al. 2020

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The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known. The aim of this study was to assess the intake and metabolism of TRP in elderly patients with mood disorders. Ninety subjects in three groups, 30 subjects each, were enrolled in this study: controls (healthy young adults, group I) and elderly individuals without (group II) or with (group III) symptoms of mild and moderate depression, as assessed by the Hamilton Depression Rating Scale (HAM-D) and further referred to as mood disorders. The average TRP intake was evaluated with the nutrition calculator. Urinary levels of TRP, 5-hydroxyindoleacetic acid (5-HIAA), L-kynurenine (KYN), kynurenic acid (KynA), xanthurenic acid (XA), and quinolinic acid (QA) were determined by liquid chromatography with tandem mass spectrometry and related to creatinine level. The average daily intake of TRP was significantly lower in group III than the remaining two groups, but group III was also characterized by higher urinary levels of KYN, KynA, XA, and QA as compared with younger adult individuals and elderly patients without mood disorders. Therefore, mild and moderate depression in the elderly may be associated with a lower intake of TRP and changes in its kynurenine metabolic pathway, which suggests a potential dietary TRP-based intervention in this group of patients.

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“…Nortriptyline is a tricyclic antidepressant, which was originally developed as an antidepressant and is known to have anticholinergic action as an adverse reaction. The anticholinergic action systemically suppresses secretion of serous fluids, causing cardiotoxicity, cognitive disturbance, confusion, seizure, blurred vision, dry mouth, urinary difficulty, and constipation [5,6]. Because of these side effects, tricyclic antidepressants are contraindicated in the event of severe impairment of myocardial performance, seizure disorders, glaucoma or large prostate [7].…”

Section: Discussionmentioning

confidence: 99%