Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction

Williams, Michelle; Kwieciński, Jacek; Doris, Mhairi; McElhinney, Priscilla; D’Souza, Michelle; Cadet, Sebastien; Adamson, Philip D; Moss, Alastair J; Alam, Shirjel; Hunter, Amanda; Shah, Anoop; Mills, Nicholas L; Pawade, Tania; Wang, Chengjia; Weir‐McCall, Jonathan R.; Bonnici-Mallia, Michael; Murrills, Christopher; Roditi, Giles; Beek, Edwin Jacques Rudolph van; Shaw, Leslee J.; Nicol, Edward; Berman, Daniel S.; Slomka, Piotr J.; Newby, David E.; Dweck, Marc R; Dey, Damini

doi:10.1016/j.jcmg.2021.03.004

Cited by 38 publications

(24 citation statements)

References 35 publications

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“…Women had significantly fewer atherosclerotic plaques of all subtypes compared to men (calcified, noncalcified, and low-attenuation plaque burdens (p < 0.001 for all)). However, as with men, a low-attenuation plaque burden predicted future myocardial infarction events [11].…”

Section: Pathophysiology Of Cad In Womenmentioning

confidence: 94%

Coronary Artery Disease in Women: A Comprehensive Appraisal

Pravda

Karny-Rahkovich

Shiyovich

et al. 2021

JCM

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Coronary artery disease (CAD) is a significant cause of illness and death amongst women. The pathophysiology, manifestations, and outcomes of CVD and CAD differ between sexes. These sex differences remain under-recognized. The aim of this review is to highlight and raise awareness of the burden and unique aspects of CAD in women. It details the unique pathophysiology of CAD in women, cardiovascular risk factors in women (both traditional and sex-specific), the clinical presentation of CAD in women, and the range of disease in obstructive and non-obstructive CAD in women.

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Section: Pathophysiology Of Cad In Womenmentioning

confidence: 94%

Coronary Artery Disease in Women: A Comprehensive Appraisal

Pravda

Karny-Rahkovich

Shiyovich

et al. 2021

JCM

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“…In particular, men remain more likely to suffer from ischemic heart disease, and women with coronary artery disease rarely present syndromes ( 34 ). Furthermore, compared to men, women more often experience less atherosclerotic plaque, manifested by chest pain and a lower risk of subsequent myocardial infarction ( 35 ). Our available data demonstrated that LEASO is an effective predictor in women as men, with a LEASO relative to a twofold increase in the risk of MACCEs.…”

Section: Discussionmentioning

confidence: 99%

Novel Insight Into Long-Term Risk of Major Adverse Cardiovascular and Cerebrovascular Events Following Lower Extremity Arteriosclerosis Obliterans

Deng

Wang

et al. 2022

Front. Cardiovasc. Med.

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“…[12][13][14] Women also have lower prevalence of obstructive coronary atherosclerosis, 15,16 even with comparable levels of ischemia 17,18 and are less likely to have adverse plaque characteristics and less atherosclerotic plaque of all subtypes compared with men. 19 Interestingly, sex differences in coronary artery disease (CAD) severity and plaque composition are most evident among young adults and attenuated in older adults, [20][21][22] thought to be related to the protective role of endogenous estrogen in premenopausal women. These sex differences in coronary size and atherosclerosis development appear to contribute to higher prevalence of INOCA in women.…”

Section: Coronary Anatomy and Physiologymentioning

confidence: 99%

Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries

Reynolds

Merz

Berry

et al. 2022

Circulation Research

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Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional cardiovascular risk factors play an important role in the development of IHD in women, women may experience sex-specific IHD risk factors and pathophysiology, and thus female-specific risk stratification is needed for IHD prevention, diagnosis, and treatment. Emerging data from the past 2 decades have significantly improved the understanding of IHD in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite this progress, sex differences in IHD outcomes persist, particularly in young women. This review highlights the contemporary understanding of coronary arterial function and disease in women with no obstructive coronary arteries, including coronary anatomy and physiology, mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries, noninvasive and invasive diagnostic strategies, and management of IHD.

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Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction

Cited by 38 publications

References 35 publications

Coronary Artery Disease in Women: A Comprehensive Appraisal

Coronary Artery Disease in Women: A Comprehensive Appraisal

Novel Insight Into Long-Term Risk of Major Adverse Cardiovascular and Cerebrovascular Events Following Lower Extremity Arteriosclerosis Obliterans

Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries

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