Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort

Millstein, Richard; Pyle, Laura; Bergman, Bryan C.; Eckel, Robert H.; Maahs, David M.; Rewers, Marian; Schauer, Irene E.; Snell‐Bergeon, Janet K.

doi:10.1016/j.jdiacomp.2018.01.002

Cited by 25 publications

(20 citation statements)

References 33 publications

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“…Another important finding of our study is that the association between the TyG index and the risk of MI was more pronounced in women than men, which is in accordance with previous studies [ 34 , 35 ]. A cohort study showed that higher fasting serum insulin levels and HOMA-IR were associated with incident hypertension in women, but not in men [ 34 ].…”

Section: Discussionsupporting

confidence: 93%

“…A cohort study showed that higher fasting serum insulin levels and HOMA-IR were associated with incident hypertension in women, but not in men [ 34 ]. Moreover, the Coronary Artery Calcification in Type 1 Diabetes cohort study found that type 1 diabetes affected adipose and skeletal muscle insulin sensitivity to a greater extent in women than in men, which might have contributed to the greater relative increase in cardiovascular risk in women [ 35 ]. A possible mechanism for this finding may be a role of estrogen in premenopausal cardiovascular protection and enhanced insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

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Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort

Tian

Zuo

Chen

et al. 2021

Cardiovasc Diabetol

125

104

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Background The triglyceride–glucose (TyG) index, which is a simple surrogate marker of insulin resistance, has been suggested as a contributor of cardiovascular disease. However, evidence on the effect of long-term elevation of the TyG index exposure on myocardial infarction (MI) is limited. The current study aimed to evaluate the association of baseline and long-term elevation of the TyG index exposure with the risk of MI. Methods A total of 98,849 participants without MI at baseline (2006) were enrolled from the Kailuan study. The baseline TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The long-term TyG index was characterized in two ways as follows. The updated mean TyG index was calculated as the mean of TyG index at all previous visits before MI occurred or the end of follow-up; alternatively, the TyG index was calculated as the number of visits with a high TyG index in 2006, 2008, and 2010, ranging from 0 (no exposure) to 3 (had high TyG index at all three study visits). Hazard ratio (HR) and 95% confidence interval (CI) was estimated using multivariable Cox proportion hazard models. Results During a median follow-up of 11.03 years, 1555 incident MI occurred. In the multivariable-adjusted model, the risk of MI increased with quartiles of the baseline and updated mean TyG index, the HR in quartile 4 versus quartile 1 was 2.08 (95% CI,1.77–2.45) and 1.58 (1.18–2.12), respectively. Individuals with a high TyG index at all three visits had a 2.04-fold higher risk (95% CI, 1.63–2.56) of MI compared with no exposure. Subgroup analyses showed that the associations were more pronounced in women than in men (Pinteraction = 0.0411). Conclusions Elevated levels of the baseline and long-term TyG index are associated with an increased risk of MI. This finding indicates that the TyG index might be useful in identifying people at high risk of developing MI.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort

Tian

Zuo

Chen

et al. 2021

Cardiovasc Diabetol

125

104

View full text Add to dashboard Cite

show abstract

“…[20,22] Our findings might be, to a certain extent, explained by the high magnitude of insulin resistance and the direct impact of insulin resistance and hormonal status on enzymes implicated in lipid/lipoprotein metabolism in females. [16,23] However, the males predominated among those with combined high plasma Tg/low plasma HDL-C and mixed high plasma Tg/high plasma LDL-C/low plasma HDL-C lipid/lipoprotein abnormalities. This finding has potential clinical consequence, given the well-known relationship between combined and mixed lipid/lipoprotein abnormalities and their various adverse vascular events in DM [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria

Amadi¹,

Ayoade²,

Unyime³

et al. 2020

SJCM

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“…The development of IR is also related to the gender of T1DM patients. Millstein et al found that T1DM affected adipose and skeletal muscle insulin sensitivity to a greater extent in women than in men [ 25 ]. Participants in the control groups presented higher Morbus values (M-values) than those with DM, regardless of gender.…”

Section: What Does It Mean To Be Insulin Resistant?mentioning

confidence: 99%

The Causes of Insulin Resistance in Type 1 Diabetes Mellitus: Is There a Place for Quaternary Prevention?

Wołosowicz

Łukaszuk

Chabowski

2020

IJERPH

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Diabetes mellitus was the first non-communicable disease that was recognized by the United Nations as a 21st-century pandemic problem. Recent scientific reports suggest that people with type 1 diabetes mellitus also develop insulin resistance, which is generally considered to be a distinctive feature of type 2 diabetes mellitus. The causes of insulin resistance in type 1 diabetes mellitus were explored, but there was a lack of publications that connected the risk factors of insulin resistance in type 1 diabetes mellitus with the proposition of repair mechanisms that are offered by quaternary prevention. Toward this end, the present review is an attempt to combine the previous reports on the causes of insulin resistance in type 1 diabetes mellitus and a brief review of quaternary prevention. The destructive effect of insulin resistance on many physiological processes that predisposes the individual to chronic diabetes complications creates an urgent need to introduce effective therapeutic methods for preventing the development and progression of this pathology.

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Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort

Abstract: We found that type 1 diabetes affected adipose and skeletal muscle insulin sensitivity to a greater extent in women than in men, perhaps contributing to the greater relative increase in cardiovascular risk in women with type 1 diabetes.

Cited by 25 publications

References 33 publications

Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort

Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort

Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria

The Causes of Insulin Resistance in Type 1 Diabetes Mellitus: Is There a Place for Quaternary Prevention?

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