Sex-specific differences in the prevalence of and risk factors for hyperuricemia among a low-income population in China: a cross-sectional study

Qi, Dongwang; Liu, Jie; Wang, Conglin; Wang, Lixia; Zhang, Xinxin; Lin, Qiuxing; Tu, Jun; Wang, Jinghua; Ning, Xianjia; Cui, Jingqiu

doi:10.1080/00325481.2020.1761133

Cited by 23 publications

(25 citation statements)

References 40 publications

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“…UA levels are often increased in subjects with MetS. In our study, the incidence of hyperglycemia in all subjects and control group was 20.2% and 16.1%, respectively, which was slightly higher than the report from Qi et al, 9 and was up to 33.3% in the MetS group. In HUA patients, the incidence of MetS was up to 45.4% in males and 26.3% in females, higher than that of the normal SUA group.…”

Section: Discussioncontrasting

confidence: 69%

The association of serum uric acid with metabolic syndrome and its components—From a single‐clinical centre in China

Liu

et al. 2020

Int J Clin Pract

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Background and Objectives Increasing evidence suggests that uric acid (UA) levels may play a role in the MetS. The purpose of this study was the association of serum uric acid with metabolic syndrome and its components from a single‐clinical centre in China. Subjects and Methods We retrospectively analysed the physical examination information of patients at the Health Checkup Centre of the Beijing Friendship Hospital, Capital Medical University in 2018. MetS was defined as ≥3 of the risk factors according to the revised Harmonised criteria. Statistical analyses were performed using the SPSS statistical software package, version 22.0 (IBM Corporation, Armonk, NY, USA). Results A total of 36 663 subjects were retrospectively analysed. The incidence of MetS was 23.6% amongst the study participants and 38.9% in subjects with HUA. The incidence of HUA was 33.3% in the MetS group. Higher SUA levels were correlated with an increased risk of having full MetS, hypertriglyceridemia and low HDL‐C after adjustment (all P < .001 for the trend). Only in males higher SUA levels correlated with an increased risk of being overweight. Individuals with the highest quartile of SUA had no significant association with having HP in males, and a significant association between SUA levels and hypertension was only seen in the highest quartile of females. Males with the highest quartile of SUA (Q4) and females with the higher quartiles of SUA (Q3 and Q4) had no significant association with having hyperglycemia. Conclusion The incidence of HUA was increased in the MetS group consisting of Chinese patient subjects living in Beijing. SUA is strongly associated with full MetS as well as hypertriglyceridemia and low HDL‐C. The relationship between HUA and an overweight BMI, HP and hyperglycemia varied by gender.

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Section: Discussioncontrasting

confidence: 69%

The association of serum uric acid with metabolic syndrome and its components—From a single‐clinical centre in China

Liu

et al. 2020

Int J Clin Pract

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“…risk factors for HUA based on sex differences found that BUN was an independent risk factor for HUA in both male and female groups. 54 In another study, univariate analysis and multivariate analysis were used successively, and the results showed that BUN was an independent risk factor for the occurrence of HUA. 55 BUN was filtered out of the body from the glomerulus.…”

Section: Serum Creatinine (Scr)mentioning

confidence: 99%

<p>Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus</p>

Shi¹,

Niu²,

Wu³

et al. 2020

RMHP

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The study aimed to identify diseases that exhibit significant differences between hyperuricaemia (HUA) and non-hyperuricaemia (NHUA) groups and analyse the risk factors for HUA based on the related diseases in type 2 diabetes mellitus (T2DM). Methods: A total of 3264 T2DM patients were investigated from 2013 to 2017 in the Jinyang and Sanlin communities by obtaining basic data from the electronic medical record system (EMRS). From September 2018 to July 2019, 3000 patients (264 patients were missing during follow-up) were investigated with questionnaires, physical examinations and biochemical index tests. After removing missing values, 2899 patients were divided into HUA and NHUA groups. The chi-square test was used to identify diseases with differences. Using Lasso analysis and logistic regression analysis, risk factors for HUA based on the related diseases were obtained. The C-index, receiver operating characteristic (ROC) curve and calibration plot were used to validate the discrimination and accuracy of the factors. Results: The chi-square test showed that there were significant differences in coronary heart disease (CHD) and diabetic nephropathy (DN) between the HUA group and the NHUA group. Through Lasso regression, glycosylated haemoglobin A1c (HbA1c), triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCR) were screened in the CHD group. Body mass index (BMI), HbA1c, total cholesterol (TC), TG, BUN, SCR and urine microalbumin (UMA) were screened in the DN group. The P-value of all the variables was less than 0.05. Through the C-index, calibration, and ROC curve analyses, these risk factors had medium accuracy. Conclusion: HUA was significantly related to CHD and DN. The level of UA was correlated with HbA1c, TG, BUN, and SCR based on CHD. The level of UA was associated with BMI, HbA1c, TC, TG, BUN, SCR, and UMA based on DN.

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“… 11 Additionally, hyperuricemia has been associated with several medical and metabolic conditions, including the different components of the metabolic syndrome. 12 , 13 Gender-specific differences in the prevalence and risk factors of hyperuricemia have been reported. 13 , 14 Additionally, gender is believed to further modify the associations of uric acid with glycemic control, 15 cardiovascular risk factors, 16 metabolic syndrome, 17 and kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes

Eljaaly¹,

Mujammami²,

Nawaz³

et al. 2021

DMSO

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Objective Patients with diabetes are at higher risk of the negative consequences of hyperuricemia. The objective of this study was to investigate gender and age-specific differences in the uric acid levels and to evaluate the associated risk factors among patients with diabetes. Methods A retrospective cross-sectional study was conducted at Strategic Center for Diabetes Research from September 2019 to January 2020, among adult type-2 diabetic patients. Serum uric acid (SUA) and several other metabolic and clinical parameters were examined. Multiple regression analysis was done to identify risk factors independently associated with hyperuricemia. Results A total of 433 patients were included in the analysis. SUA level was higher in males than females (5.82±1.65 mg/dL versus 5.29±1.54 mg/dL, p < 0.001). The prevalence of hyperuricemia was higher in females than males (28.8% versus 20.5%, p = 0.049). There was no significant difference in uric acid levels or the prevalence of hyperuricemia by age groups in the total sample or gender-stratified samples. In multivariate analysis, hyperuricemia was associated with bigger hip circumference (odds ratios [OR] were 1.03, 95% CI = 1.01–1.05), higher triglycerides (OR = 1.005, 95% CI = 1.002–1.008), and higher serum creatinine (OR = 1.34, 95% CI = 1.21–1.49). Hip circumference, total cholesterol, high-density lipoprotein, and serum creatinine were independent risk factors in males, while triglycerides and higher serum creatinine were independent risk factors among females. Conclusion The present study demonstrates gender-specific differences in the uric acid levels and hyperuricemia prevalence. In males and females, hyperuricemia was associated with hip circumference, total cholesterol, high-density lipoprotein, triglycerides, and serum creatinine. Future large studies are needed to confirm our findings, especially in elderly females.

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Sex-specific differences in the prevalence of and risk factors for hyperuricemia among a low-income population in China: a cross-sectional study

Cited by 23 publications

References 40 publications

The association of serum uric acid with metabolic syndrome and its components—From a single‐clinical centre in China

The association of serum uric acid with metabolic syndrome and its components—From a single‐clinical centre in China

<p>Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus</p>

Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes

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