Sexual dimorphism in renal ischemia-reperfusion injury in rats: Possible role of endothelin

Müller, Veronika; Losonczy, György; Heemann, Uwe; Vannay, Ádám; Fekete, Andrea; Reusz, György; Tulassay, Tivadar; Szabó, Attila

doi:10.1111/j.1523-1755.2002.kid590.x

Cited by 150 publications

(76 citation statements)

References 33 publications

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“…1b). These results, consistent with previous observations [5, 6], demonstrate the resistance of female animals to ischemic ARF.…”

Section: Resultssupporting

confidence: 83%

“…Recent studies by Szabo and colleagues have suggested that female rats are more refractory to ischemic ARF than male rats [5, 6]. Importantly, this experimental observation seems to be consistent with some of previous clinical analyses [7, 8].…”

Section: Introductionsupporting

confidence: 79%

“…In the ischemic model, sex hormones have been implicated [5, 20]. Szabo and colleagues suggested that estrogen might play an important role in protecting females from ischemic ARF by limiting endothelin activation [5]. On the other hand, recent results by Park et al [20] showed that deprivation of estrogen in female animals by ovariectomy did not affect ischemic renal injury.…”

Section: Resultsmentioning

confidence: 97%

“…Mechanistically, very limited information is available for the gender differences in ARF. In the ischemic model, sex hormones have been implicated [5, 20]. Szabo and colleagues suggested that estrogen might play an important role in protecting females from ischemic ARF by limiting endothelin activation [5].…”

Section: Resultsmentioning

confidence: 99%

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Differential Gender Differences in Ischemic and Nephrotoxic Acute Renal Failure

Wei¹,

Wang

Dong³

2005

Am J Nephrol

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Background/Aims:Recent work has shown that female animals are more resistant to ischemic acute renal failure (ARF) than male animals. The mechanism underlying the gender difference is unclear. Moreover, whether the gender difference holds true for ARF induced by other insults is unknown. This study sought to determine the gender differences in ischemic and nephrotoxic ARF. Methods: Gender differences were tested in two experimental models of ARF. For ischemic ARF, bilateral clamping of renal pedicles was conducted in C57BL/6 and129/Sv mice followed by reperfusion. For nephrotoxic ARF, cisplatin was administered to the animals. Renal function, tissue damage, animal survival, and renal cell apoptosis were examined. Results: Ischemic ARF was significantly ameliorated in female mice, as shown by lower serum creatinine and blood urea nitrogen (BUN). Female mice also showed better renal histology, less apoptosis and caspase activation, and a much better survival rate than male mice following ischemic insult. On the contrary, female mice were more sensitive to cisplatin-induced ARF. In these animals, BUN increased at day 1 following cisplatin injection, while in males BUN increases were not shown until day 3. Higher levels of serum creatinine were also recorded in female mice. Renal histology showed severer necrotic tubular damage in females, although apoptosis and caspase activation appeared similar in both genders. Consistently, male mice survived better than females in the nephrotoxic model. Conclusion: While female mice were resistant to ischemic ARF, they appeared more sensitive to cisplatin-induced ARF. Investigation of the gender differences at the cellular and molecular levels might provide a new area for mechanistic study of ARF.

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“…1b). These results, consistent with previous observations [5, 6], demonstrate the resistance of female animals to ischemic ARF.…”

Section: Resultssupporting

confidence: 83%

Section: Introductionsupporting

confidence: 79%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Differential Gender Differences in Ischemic and Nephrotoxic Acute Renal Failure

Wei¹,

Wang

Dong³

2005

Am J Nephrol

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“…The gender differences had been documented in the studies of other ARF models. For instance, female rats were more refractory to ischemic ARF than male rats [19], whereas female rats appeared more sensitive to cisplatin-induced ARF [20]. According to these studies, the sex hormone was considered an important reason for this difference.…”

Section: Discussionmentioning

confidence: 99%

The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats

et al. 2017

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Porphyran is a sulfate galactan in the cell wall of Porphyra. Its acid hydrolysis product, oligo-porphyran (OP), was prepared and the structure studied by electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS). This oligosaccharide was mainly composed of monosulfate-oligo-galactan, disufate-oligo-galactan, trisulfate-oligo-galactan, trisulfate oligo-methyl-galactan, and 3,6-anhydrogalactose with the degree of polymerization ranging from 1 to 8. The effects of OP were investigated in the glycerol-induced acute renal failure (ARF) model. Compared with the normal group, rats from the glycerol-induced group exhibited collecting duct and medullary ascending limb dilation and casts. The OP-treated group exerted a protective effect against glycerol-induced changes. The results showed that the administration of OP markedly decreased mortality in female ARF rats. For male ARF rats, all of which survived, OP significantly decreased the blood urea nitrogen and serum creatinine levels. Ion levels in plasma and urine were significantly changed in ARF rats, whereas OP treatment almost recovered ion levels back to normal. This study showed a noticeable renal morphologic and functional protection by OP in glycerol-induced ARF rats.

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Sex differences in cerebral ischemia: Possible molecular mechanisms

Siegel

Turtzo

McCullough

2010

J of Neuroscience Research

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Sex is emerging as an important factor in the etiology and expression of many different pathological conditions, including stroke. Initially, the levels of sex hormones were thought to be the major contributor to these sex differences, especially after puberty, when gonadal steroid levels sharply diverge between the sexes. More recently, it is recognized that sex differences also result from the organizational effects of sex hormone exposure early in development, even in the absence of hormone exposure later in life, as well as effects mediated by the sex chromosomes themselves. Epigenetic modifications of developmental genes important in sexual differentiation and the response to sex steroid hormones are also emerging as another important contributor to sex differences in disease expression. This review describes recent research on the relationship between hormones, organizational-activational effects of gonadal steroids, and epigenetic modifications in brain pathology, focusing specifically on cerebral ischemia.

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Sexual dimorphism in renal ischemia-reperfusion injury in rats: Possible role of endothelin

Abstract: Female rats enjoy relative protection against postischemic renal failure. Furthermore, in intact males the effects of androgens upon ischemic kidney damage seem to be mediated by endothelin-induced vascular changes.

Cited by 150 publications

References 33 publications

Differential Gender Differences in Ischemic and Nephrotoxic Acute Renal Failure

Differential Gender Differences in Ischemic and Nephrotoxic Acute Renal Failure

The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats

Sex differences in cerebral ischemia: Possible molecular mechanisms

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