Sexual Dysfunction in 1,274 European Men Suffering from Lower Urinary Tract Symptoms

Vallancien, Guy; Emberton, Mark; Harving, Niels; Moorselaar, R. Jeroen A. van

doi:10.1097/01.ju.0000067940.76090.73

Cited by 179 publications

(144 citation statements)

References 9 publications

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“…A higher risk of ED has been reported in men using calcium channel antagonist, non-selective b-blocker or diuretic compared with non-users. [7][8][9][10][11] Consistent with other studies, 8,11 we found no increased risk of ED in men using angiotensin-converting enzyme inhibitors or serum lipid-lowering agents.…”

Section: Cardiovascular Drug Use and The Incidence Of Ed R Shiri Et Alsupporting

confidence: 81%

“…6 Previous cross-sectional studies have shown associations between heart disease, high blood pressure and their medications use, and ED. 1,5,7 Longitudinal studies have also found a higher incidence of ED in men with hypertension than in those with normal blood pressure. 3,4 In these studies, heart disease was not significantly associated with ED.…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular drug use and the incidence of erectile dysfunction

et al. 2006

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It is unclear whether high blood pressure per se or antihypertensive drug use causes erectile dysfunction (ED). The aim of this study was to investigate the effect of cardiovascular diseases and their concomitant medications use on the incidence of ED. The target population consisted of men aged 55, 65 or 75 years old residing in the study area in Finland in 1999. Questionnaires were mailed to 2837 men in 1999 and to 2510 of them 5 years later. The follow-up sample consisted of 1665 men (66% of those eligible) who responded to both baseline and follow-up questionnaires. Men free of moderate or severe ED at baseline (N ¼ 1000) were included in the study. ED was assessed by two questions on subject ability to achieve or maintain an erection sufficient for intercourse. Poisson regression model was used in the multivariable analyses. The risk of ED was higher in men suffering from treated hypertension or heart disease than in those with the untreated condition. The risk of ED was higher in men using calcium channel inhibitor (adjusted relative risk (RR) ¼ 1.6, 95% confidence interval (CI) 1.0-2.4), angiotensin II antagonist (RR ¼ 2.2, 95% CI 1.0-4.7), non-selective b-blocker (RR ¼ 1.7, 95% CI 0.9-3.2) or diuretic (RR ¼ 1.3, CI 0.7-2.4) compared with non-users. ED was not associated with using organic nitrates, angiotensin-converting enzyme inhibitors, selective b-blockers and serum lipid-lowering agents. In summary, calcium channel inhibitors, angiotensin II antagonists, non-selective b-blockers and diuretics may increase the risk of ED.

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Section: Cardiovascular Drug Use and The Incidence Of Ed R Shiri Et Alsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Cardiovascular drug use and the incidence of erectile dysfunction

et al. 2006

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“…28,[30][31][32] In the Multinational Survey of the Aging Male, LUTS were an independent risk factor for ED after controlling for age and comorbidities. 28 We presume that the improvement observed in erectile function in the TURP group in our study was caused by relief of obstructive urinary symptoms.…”

Section: Discussionmentioning

confidence: 99%

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

et al. 2009

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The effect of transurethral resection of the prostate (TURP) on erectile function is still controversial, and available evidence is conflicting. One of the possible mechanisms of post-TURP erectile dysfunction (ED) is direct thermal injury to the erectile nerves. The aim of this study was to investigate the effect of TURP on erectile function. Fifty patients undergoing TURP for obstructive benign prostatic hyperplasia (HBP) were prospectively included in the study, and 50 age-matched patients undergoing transurethral resection of the superficial bladder tumor were also prospectively included as a control group. All patients completed the international index of erectile function (IIEF-15), the international prostatic symptom score (IPSS) and the Hospital Anxiety and Depression Scale at inclusion in the study and then at the 3-and 6-month follow-up evaluation. Capsular perforations during TURP were prospectively reported by the operating surgeon. There was a significant improvement of erectile function in the TURP group despite the onset of ejaculation disorders in 70% of the patients. Improvement of erectile function was also found in the subgroup of patients with capsular perforation during TURP. Comparison with the control group showed that at preoperative evaluation, patients in the TURP group had more severe urinary symptoms and worse erectile function than did those of the control group. At the postoperative period, the IPSS score became comparable in the two groups, with major improvement of erectile function in the TURP group. We concluded that TURP improved erectile function in HBP patients with severe urinary symptoms. This improvement of erectile function was observed even in case of capsular perforation.

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“…19 The rates seen in the present study were somewhat higher than the prevalence rates of approximately 40-60% for ED and EjD observed in other studies. 3,[20][21][22][23] It should be noted that these studies had important differences in sample sizes, patient age ranges and the types of questionnaires and survey methods used. Taken together, however, the results of these studies clearly indicate that ED and EjD are common conditions in men with LUTS/BPH.…”

Section: Discussionmentioning

confidence: 99%

Effects of alfuzosin 10 mg once daily on sexual function in men treated for symptomatic benign prostatic hyperplasia

2007

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We evaluated the effects of extended-release alfuzosin HCl 10 mg once daily (q.d.) on sexual function in men with lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). In a randomized, double-blind, placebo-controlled study of men aged Z50 years, after a 28-day placebo run-in period, patients were randomized to receive alfuzosin 10 mg q.d. or matching placebo for 28 days. The mean change from baseline (day 1) in sexual function on day 29 was assessed using the Danish Prostate Symptom Score Sex (DAN-PSSsex) questionnaire. A total of 372 patients were randomized to receive alfuzosin (n ¼ 186) or placebo (n ¼ 186), with 355 completing the study. At baseline, 64% of the patients reported erectile dysfunction (ED) and 63% reported ejaculatory dysfunction (EjD). For the 320 patients who completed the DAN-PSSsex, alfuzosin treatment was associated with a significant improvement in the mean change from baseline in erectile function on day 29 compared with placebo (P ¼ 0.02). No significant difference was observed between the two treatment groups in the mean change from baseline in ejaculatory function on day 29. For patients with ED at baseline, a marginal improvement in erectile function was demonstrated with alfuzosin treatment (P ¼ 0.09 vs placebo). For patients with EjD at baseline, the mean change from baseline in ejaculatory function with alfuzosin was comparable to that with placebo. Dizziness was the most common adverse event with alfuzosin treatment (5 vs 0% with placebo), with other adverse events reported with comparable frequency in both treatment groups. After 1 month of treatment, alfuzosin 10 mg q.d. significantly improved erectile function in men with lower urinary tract symptoms/ benign prostatic hypertrophy and had no adverse effect on ejaculatory function.

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Sexual Dysfunction in 1,274 European Men Suffering from Lower Urinary Tract Symptoms

Cited by 179 publications

References 9 publications

Cardiovascular drug use and the incidence of erectile dysfunction

Cardiovascular drug use and the incidence of erectile dysfunction

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

Effects of alfuzosin 10 mg once daily on sexual function in men treated for symptomatic benign prostatic hyperplasia

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