The aim of this review is to discuss the topic about sexual dysfunction impact on the diabetic patients and also to discuss the quality of life in diabetic patients. Diabetes mellitus is a chronic and progressive metabolic disorder characterized by hyperglycaemia resulting from inadequate production of insulin and insulin action, or both. DM can potentially affect in various areas of life, ranging from physical complications to psychological imbalance, among which the wellknown and most common difficulty is sexual dysfunction in both male and female. In men, the diabetic person has three times more chance for affecting with sexual dysfunction as compared to a non-diabetic person. In women, the association between diabetes and sexual dysfunction are less complicated as compared to diabetic men. The female sexual functions are more linearly related to social and psychological components than the physiological changes of diabetes.Thus, the prevalence rate was reported higher in diabetic women as compared to non-diabetic women. The diabetic patients also have been present with different clinical conditions, micro and macro vascular complications, including hypertension, overweight, metabolic syndrome, CVD, atherogenic dyslipidaemia, retinopathy, nephropathy, and neuropathy. This can cause damage to the nerves and blood vessels, as per which it can cause a potential increase in the risk chance for sexual dysfunction in both men and women.