Sexual function and quality of life in a national cohort of bilateral testicular cancer survivors

Bandak, Mikkel; Lauritsen, Jakob; Johansen, Christoffer; Kreiberg, Michael; Skøtt, Julie Wang; Agerbæk, Mads; Holm, Nanna; Daugaard, Kirsten Gedske

doi:10.1093/annonc/mdy283.121

Cited by 3 publications

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“…Five studies assessed anxiety (3 reported prevalence, while 3 reported severity) using the HADS-A (four studies) or the Spielberger State Anxiety Scale 10-item inventory (SSAS-10). The reported prevalence of borderline abnormal or abnormal anxiety was 6.9%, 33 20% 32 and 21.1%. 34 Two studies 29 , 33 found mean HADS-A scores of 3.2 to 6.16 (scale range 0–21), and another study 30 reported SSAS-10 scores of 16.2 to 18.6 (scale range unclear).…”

Section: Resultsmentioning

confidence: 95%

“…Each study included between 29 and 2260 participants. The total number of participants across all studies was 2898 (one study 31 is excluded from this count as they are the same participants from another publication, 32 but each study reported different outcomes). The overall participant response rate average was 58.8% (range: 7–93%).…”

Section: Resultsmentioning

confidence: 99%

“…Five of these studies included survivors who also had radiotherapy. A single study 32 indicated that a few participants received more than two treatments. Only one study 28 exclusively included a sample of survivors who received both orchiectomy and chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

“… NA NR NR 5 Fair Manhães et al, 2019 33 HADS [≥8], 6.9% HADS [0–21], 3.2 (3.8) NA NR Sexual Confidence and Functioning (p = 0.04), Cognitive-Emotional Regulation (p = 0.001), and Specific Sexual Functioning (p = 0.04) were predictors of anxiety symptoms (R 2 = 61%). 8 Fair Whitford et al, 2019 29 NA HADS [0–21], Baseline Group A: 6.16 (4.08), baseline group B: 4.13 (3.69); FU Group A: 4.72 (3.36), FU Group B: 3.25 (3.69) NA Non sig: Treatment type (surgery alone vs surgery + chemo) NR Depression 1 Good Bandak et al, 2018 32 HADS [≥7], 7% NR NA NR NR 3 Good Skott et al, 2019 34 HADS [>7], 4.7% NR NA Non-sig: age NR 4 Fair Adams et al, 2018 30 NR CES-D10 [0–30]: baseline exercise group: 5.3 (4.7), baseline control: 4.5 (4.4) NA NR NR 5 Fair Manhães et al, 2019 33 HADS [≥9], 6.9% HADS [0–21], 1.8 (3.7) No NA Sexual Confidence and Functioning was associated with symptoms of depression (p = 0.01). Cognitive-Emotional Regulation (p = 0...…”

Section: Resultsmentioning

confidence: 99%

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An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors

Rincones¹,

Smith²,

Naher³

et al. 2021

CMAR

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Purpose: A diagnosis of testicular cancer (TC) at a relatively young age can have a dramatic impact on the psychological well-being of those affected. The aim of this review was to synthesize recent evidence to provide an updated account of the prevalence, severity and correlates of anxiety, depression, fear of cancer recurrence (FCR) and distress in TC survivors. Patients and Methods: A systematic literature review was conducted from September 2017 until June 2020 using electronic databases including Embase, MEDLINE, PsycINFO, Scopus and Web of Science. Study eligibility and quality were independently assessed by two reviewers. Narrative synthesis was used to depict the severity (mean/median scores), prevalence (proportions above standard clinical thresholds) and correlates of study outcomes. Results: A total of 988 articles were identified for screening after duplicate removal. Fiftysix full-text articles were screened, and eight articles met the inclusion criteria. The reported prevalence of the outcomes varied across studies (clinical levels of anxiety ranged from 6.9% to 21.1%, depression varied from 4.7% to 7%, distress was found between 25% and 41.4%, prevalence of FCR was not reported). Few studies compared TC survivors with other populations. Correlates of poorer psychological outcomes included younger age, relationship status, employment status, poorer sexual functioning, impaired masculinity and coping strategies. Conclusion: Anxiety seems to be the most common issue for TC survivors. Men who are single or unemployed appear most at risk of poorer psychological outcomes, which seem associated with impaired masculinity and sexual function. More research is needed to identify TC survivors most likely to need one of the increasing number of psychological interventions being developed for TC survivors.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors

Rincones¹,

Smith²,

Naher³

et al. 2021

CMAR

View full text Add to dashboard Cite

show abstract

“…Therefore, 21 full-text articles were retrieved and evaluated for eligibility based on the inclusion criteria. Seven articles were excluded as a result of not fulfilling our inclusion criteria [ 1 , 3 , 4 , 6 , 10 , 12 , 14 , 15 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Finally, 14 studies that fulfilled the eligibility criteria were included in the systematic review and meta-analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Erectile dysfunction among testicular cancer survivors: A systematic review and meta-analysis

Workineh

Kasa

Ayalew

et al. 2021

Heliyon

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Background: Erectile dysfunction is one of the common complications of testicular cancer with the prevalence of 11.3% to 84%. It has devastating effects on men and partner's quality of life, sexual satisfaction, and sexual experience. The findings of the previous studies on this matter were uneven and inconsistent. Therefore, this systematic review and meta-analysis is conducted in order to acquire a more recent and comprehensive result. Methods and materials:To search and retained all the eligible articles different databases were searched. These includes PubMed, Scopus, Goggle scholar, Science Direct, African Index Medicus, African Journal online, EMBASE, and Cochrane Library. To extract all the relevant information, a standardized data extraction checklist was prepared. STATA 14 statistical software was utilized to analyze the data. I 2 statistics was employed to check for the heterogeneity of studies.Using a funnel plot and Egger's regression test publication bias was checked. Then, a randomeffect model was computed to estimate the pooled prevalence of erectile dysfunction.Result: Fourteen full-text studies were included in this systematic review and meta-analysis. The pooled prevalence of erectile dysfunction among testicular cancer survivors was found to be 34.60% (95% CI: 25. 89, 43.30% [I 2 = 95.9%, p = 0.000]). Study design subgroup analysis indicated that the pooled prevalence of erectile dysfunction was 50.02% (95% CI: 22.78, 77.28% [I 2 = 96.1, p = 0.000]) and 27.36. % (95% CI: 19.23, 34.48% [I 2 = 91.6, P = 0.000]) in the case control and cohort studies respectively. Likewise, the level of erectile dysfunction was varied based on erectile dysfunction measuring tools and testicular cancer treatment modalities. Conclusion:The pooled prevalence of erectile dysfunction in testicular cancer survivors was found to be high. It had also a considerable discrepancy between the study designs, and measuring tools and treatment modalities of testicular cancer. Therefore, there is a sound to diminish the high burden of this problem.

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Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies

Kholbobozoda,

Kostin,

Vorobyev

et al. 2024

Sib. onkol. ž.

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Introduction. Testicular cancer (TC) mostly affect young men of reproductive age. Several studies have shown correlation between the level of sex hormones in testicular cancer and serum tumor markers. However, currently, the relationship between hormone levels before orchidectomy and the clinical and pathomorphological characteristics of the tumor has not been sufficiently studied. Aim of the study: to analyze the relationship between hormone levels and the clinical stage and histological characteristics of the tumor in patients with testicular cancer and to develop prognostic models. Material and Methods. This prospective single-center study included 66 patients with testicular cancer. Localized, locally advanced and metastatic testicular cancer was diagnosed in 55 (83.3 %), 9 (13.6 %) and 2 (3.0 %) patients, respectively. A preoperative assessment of hormones such as total and free testosterone (T), estradiol (E2)), gonadotropic hormones (LH, FLH, Prolactin) and b-HCG was carried out. Patients were divided into 2 groups depending on the histological structure of the tumor: seminoma (n=31) and non-seminoma (n=35). The following parameters were assessed: tumor size, lymphovascular invasion and rete testis invasion. Results. In non-seminoma tumors, the values of sex hormones and beta-hCG were higher, but the values of gonadotropic hormones were lower compared with typical seminomas (p<0.05). High concentrations of b-HCG were observed predominantly in pT3 compared to pT1 stages (p=0.018). Correlation analysis revealed a connection between total (ρ=0.351; p=0.004) and free T (ρ=0.342; p=0.008), E2 (ρ=0.292; p=0.022), b-HCG (ρ=0.244; p= 0.048), LH (ρ=-0.287; p=0.039), FSH (ρ=-0.264; p=0.04) and the size of the primary tumor. The presence of rete testis invasion was accompanied by a low LH value and a high b-HCG value compared to patients without this prognostic parameter (p=0.015, p<0.001, respectively). Prognostic models were developed to determine the probability of histological structure and the presence of rete testis invasion (p<0.001) with high sensitivity (82.1 % and 76.5 %) and specificity (76.9 % and 100 %). Conclusion. The findings suggest that non-seminoma tumors are associated with changes in the pituitary-gonadal (HPG) axis. The high values of sex hormones and low values of gonadotropic hormones before orchidectomy are associated with a large size of the primary tumor. Additionally, a low LH value and a high b-HCG value are predictors of rete testis invasion. High b-HCG levels are associated with more aggressive tumor biology and poor prognosis.

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Sexual function and quality of life in a national cohort of bilateral testicular cancer survivors

Cited by 3 publications

References 0 publications

An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors

An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors

Erectile dysfunction among testicular cancer survivors: A systematic review and meta-analysis

Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies

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