Sexual function in women with complete androgen insensitivity syndrome

Minto, Catherine L; Liao, Keng-Mao; Conway, Gerard S.; Creighton, Sarah M.

doi:10.1016/s0015-0282(03)00501-6

Cited by 148 publications

(88 citation statements)

References 16 publications

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“…Three studies of orgasmic function report that women with CAIS can reach sexual climax [10, 32, 33], indicating that androgens are not necessary for this aspect of sexuality in this group. Low libido, or hyposexual function, is reported by some women with CAIS [33, 34]. Interestingly, even when women report sexual dysfunction, they also report sexual satisfaction at levels that equal unaffected women [34].…”

Section: Androgen Insensitivity Syndromes (Aiss)mentioning

confidence: 99%

46,XY DSD with Female or Ambiguous External Genitalia at Birth due to Androgen Insensitivity Syndrome, 5α-Reductase-2 Deficiency, or 17β-Hydroxysteroid Dehydrogenase Deficiency: A Review of Quality of Life Outcomes

Wisniewski

Mazur

2009

International Journal of Pediatric Endocrinology

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Disorders of sex development refer to a collection of congenital conditions in which atypical development of chromosomal, gonadal, or anatomic sex occurs. Studies of 46,XY DSD have focused largely on gender identity, gender role, and sexual orientation. Few studies have focused on other domains, such as physical and mental health, that may contribute to a person's quality of life. The current review focuses on information published since 1955 pertaining to psychological well-being, cognition, general health, fertility, and sexual function in people affected by androgen insensitivity syndromes, 5-α reductase-2 deficiency, or 17β-hydroxysteroid dehydrogenase-3 deficiency—reared male or female. The complete form of androgen insensitivity syndrome has been the focus of the largest number of investigations in domains other than gender. Despite this, all of the conditions included in the current review are under-studied. Realms identified for further study include psychological well-being, cognitive abilities, general health, fertility, and sexual function. Such investigations would not only improve the quality of life for those affected by DSD but may also provide information for improving physical and mental health in the general population.

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Section: Androgen Insensitivity Syndromes (Aiss)mentioning

confidence: 99%

46,XY DSD with Female or Ambiguous External Genitalia at Birth due to Androgen Insensitivity Syndrome, 5α-Reductase-2 Deficiency, or 17β-Hydroxysteroid Dehydrogenase Deficiency: A Review of Quality of Life Outcomes

Wisniewski

Mazur

2009

International Journal of Pediatric Endocrinology

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“…In our case series, case 1 had consulted plastic surgeon and clinical psychologist and after confirming that she has normal length of vagina and she could lead a normal sex life after marriage, she recently got married and is leading a happy married life. Less positive outcomes have been reported for sexual functioning and sexual quality of life [19]. Problems with desire, arousal, and dyspareunia were significant in a group of women with XY disorders of sex development, most of which were due to CAIS [20].…”

Section: Casementioning

confidence: 89%

Complete Androgen Insensitivity Syndrome in Three Generations of Indian Pedigree

Kar

Sivamani

Shankar

et al. 2015

J Obstet Gynecol India

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Background Androgen insensitivity syndrome or testicular feminization syndrome is a rare X-linked recessive disorder, which encompasses a wide range of phenotypes that are caused by numerous different mutations in the androgen receptor gene. Complete androgen insensitivity syndrome occurs when the body cannot use androgens at all. People with this form of the condition have the external sex characteristics of females, but do not have a uterus and therefore do not menstruate and are unable to conceive a child (infertile). Methods In this paper, we report three cases of familial complete androgen insensitivity syndrome who presented with primary amenorrhea. Results Physical examination, ultrasonography studies, and biochemical, karyotype, and molecular cytogenetic analyses were conducted. Based on the findings, they were diagnosed and confirmed as having complete androgen insensitivity syndrome. Conclusion A multidisciplinary team is needed from disclosure of the diagnosis, gender assignment, surgical management, hormonal replacement therapy, to counseling and support.

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“…It was reported that 90% of women with CAIS had sexual difficulties when compared to the general female population, including most commonly sexual infrequency and vaginal penetration difficulty (20). Women with CAIS may have vaginal hypoplasia, clitoral hypoplasia, and psychological problems that might contribute to sexual dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Different types of androgen receptor mutations in patients with complete androgen insensitivity syndrome

Shao

Hou

et al. 2015

IRDR

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Sexual function in women with complete androgen insensitivity syndrome

Cited by 148 publications

References 16 publications

46,XY DSD with Female or Ambiguous External Genitalia at Birth due to Androgen Insensitivity Syndrome, 5α-Reductase-2 Deficiency, or 17β-Hydroxysteroid Dehydrogenase Deficiency: A Review of Quality of Life Outcomes

46,XY DSD with Female or Ambiguous External Genitalia at Birth due to Androgen Insensitivity Syndrome, 5α-Reductase-2 Deficiency, or 17β-Hydroxysteroid Dehydrogenase Deficiency: A Review of Quality of Life Outcomes

Complete Androgen Insensitivity Syndrome in Three Generations of Indian Pedigree

Different types of androgen receptor mutations in patients with complete androgen insensitivity syndrome

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