Sexual Function in Young Individuals With Multiple Sclerosis: Does Disability Matter?

Calabrò, Rocco Salvatore; Russo, Margherita; Dattola, Vincenzo; Luca, Rosaria De; Leo, Antonino; Grisolaghi, Jacopo; Bramantı, Placido; Quattrini, Fabrizio

doi:10.1097/jnn.0000000000000367

Cited by 32 publications

(20 citation statements)

References 14 publications

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“…For instance, female multiple sclerosis patients also seem to have a high prevalence of sexual dysfunction (32% in a recent study of 85 subjects, also using the FSFI) . As in our study and others in PD patients, in multiple sclerosis patients, no correlations have been found between sexual dysfunction and disease duration, lesion burden, and disability, although a link between depression and sexual dysfunction in these patients has also been suggested . In fact, a previous diagnosis of depression was meaningfully more frequent in female PD patients when compared with controls.…”

Section: Discussionsupporting

confidence: 63%

Sexual dysfunction in women with Parkinson's disease

et al. 2016

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Backgro und: Sexual dysfunction in women with Parkinson's disease is poorly understood and research in this area is scarce. The objectives of this study were sexual function characterization in female Parkinson's disease patients, description of sexual dysfunctions, correlation with disease characteristics, and comparison with matched healthy controls. Methods: Social and demographic data from consecutive female patients with Parkinson's disease and matched healthy controls were collected. The following instruments were used: UPDRS, the Hoehn and Yahr scale, the Beck Depression Inventory-II, the Female Sexual Function Index, and the Sexual Dysfunction Inventory. The only exclusion criterion was cognitive deterioration precluding comprehension of the study scope and its instruments. Results: Of the 95 patients identified, 61 were included. Mean age was 66 years (range 40-89 years), and mean disease duration was seven years (range 1-18 years). Twenty-nine presented an akinetic-rigid syndrome, 25 tremoric disease, and, the remaining, a mixed type of disease. Mean "on" total/part III UPDRS scores were 46 6 15.0 and 31 6 8.9. Sexual dysfunction was present in 86.9% of patients and 79.0% of controls, according to the Female Sexual Function Index (p < .01), and in 57.4% of patients and 22.6% of controls, according to the Sexual Dysfunction Inventory (p < .001). Multivariate binary logistic regression identified age and depressive symptoms as positive predictors in the severity of sexual dysfunction. Disease duration, UPDRS part III score, Hoehn and Yahr stage, and antiparkinsonian medication did not show significant predictive value. Conclusions: Sexual dysfunction is more prevalent in women with Parkinson's disease than in controls and is predicted by older age and severity of depressive symptoms. V C 2016 International Parkinson and Movement Disorder Society

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Section: Discussionsupporting

confidence: 63%

Sexual dysfunction in women with Parkinson's disease

et al. 2016

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“…Young adults with MS particularly may see SD as the most negative feature of the illness, given the variety of disturbances of sexual function, and the indirect effects on mental health, quality of life and intimate relationships, at a time of life when sexual activity may be at a peak and seen as particularly important. Sexual function is however often not a standard part of the consultation with healthcare professionals for PwMS [27], despite calls for its inclusion [28–30], and is therefore frequently underdiagnosed [31]. …”

Section: Discussionmentioning

confidence: 99%

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

et al. 2016

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BackgroundSexual dysfunction (SD) is very common in people with multiple sclerosis (PwMS) and contributes a significant burden of disease, particularly for young people. SD has direct neurological contributions from depression and fatigue, which occur commonly in PwMS. Modifiable factors may represent potential targets for treatment and prevention of SD. We aimed to assess the prevalence of SD and explore associations between SD and demographic and modifiable risk factors, as well as depression and fatigue in a large cohort of PwMS.MethodsWe analysed self-reported data from a large, international sample of PwMS recruited via Web 2.0 platforms, including demographic, lifestyle and disease characteristics. Specific sexual function questions included 4 items from the sexual function scale and 1 item regarding satisfaction with sexual function, part of the MS Quality of Life-54 instrument.Results2062 PwMS from 54 countries completed questions on sexual function. 81.1 % were women, mean age was 45 years, most (62.8 %) reported having relapsing-remitting MS. The majority (54.5 %) reported one or more problems with sexual function and were classified as having SD. Lack of sexual interest (41.8 % of women), and difficulty with erection (40.7 % of men) were most common. The median total sexual function score was 75.0 out of 100, and 43.7 % were satisfied with their sexual function. Regression modeling revealed independent associations between sexual function and satisfaction and a range of demographic factors, including age, as well as depression risk, antidepressant use, and fatigue in PwMS.ConclusionThis cross-sectional study shows that SD and lack of satisfaction with sexual function are associated with depression risk and fatigue, as well as modifiable lifestyle factors diet and physical activity (after adjusting for depression and fatigue). Planned longitudinal follow-up of this sample may help clarify these associations and the underlying mechanisms. There is potential to prevent and treat SD in PwMS by addressing depression and fatigue and their determinants. Clinicians and PwMS should be aware of SD and associated factors as part of a comprehensive preventive approach to managing MS.

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“…The degree and level of disability of patients can be evaluated according to the expanded disability status scale (EDSS), and sexual dysfunction (SD) is often ignored in patients with multiple sclerosis (12). It is generally believed that the higher the score of EDSS, the higher the prevalence of sexual dysfunction, and it is suggested that nursing researchers should pay attention to the evaluation of sexual dysfunction, quantify the degree of sexual injury, and improve the QOL of patients with multiple sclerosis (13).…”

Section: Analysis Of Hot Spots In Multiple Sclerosis Nursing Researchmentioning

confidence: 99%

Bibliometric analysis of multiple sclerosis nursing research based on Web of Science

Yang¹,

Tu²,

Li³

et al. 2021

Ann Palliat Med

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Background: A bibliometric analysis which are widely used to gauge the scholarly impact of any scientific publication was conducted to give a basic overview of research publications on multiple sclerosis nursing.Methods: Publications on multiple sclerosis nursing were retrieved by using a bibliometric method based on the Web of Science database .Results: A total of 825 papers collected from 49 countries were retrieved in this study. The number of publications on multiple sclerosis nursing has increased steadily since 1999, and the top 12 research institutions publishing articles and nine of the ten most prolific authors were from the United States. Articles were most frequently published in the Journal of Neuroscience Nursing, and the key words of the top 10 highly cited papers changed from quality of life (QOL) and symptoms to terms including social support, psychological problems, rehabilitation treatment, cognitive impairment, and nursing intervention. While nursing practice and neuroscience nursing were the focus of research, other topics included QOL, functional rehabilitation, symptom management, nursing intervention, and support schemes.Conclusions: Research into multiple sclerosis nursing in China is at an early stage. Greater attention to the research focus and results of top institutions and core journals, and a focus on highly cited papers are needed to advance the field.

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Sexual Function in Young Individuals With Multiple Sclerosis: Does Disability Matter?

Abstract: Healthcare professionals involved in MS, should assess patients for SD. Further studies should be fostered to better quantify SD etiology, the degree of sexual impairment, and its impact on patients' quality of life to "overcome" this problem.

Cited by 32 publications

References 14 publications

Sexual dysfunction in women with Parkinson's disease

Sexual dysfunction in women with Parkinson's disease

Sexual function in multiple sclerosis and associations with demographic, disease and lifestyle characteristics: an international cross-sectional study

Bibliometric analysis of multiple sclerosis nursing research based on Web of Science

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