Sexual functions, semen characteristics and fertility of bulls carrying the 1/29 chromosome translocation

Dyrendahl, I.; Gustavsson, I.

doi:10.1111/j.1601-5223.1979.tb01315.x

Cited by 72 publications

(21 citation statements)

References 9 publications

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“…Nevertheless, some data suggest that the percentage of unbalanced gametes is higher in cows than in bulls heterozygous for the t(1; 29). Indeed, fertility criteria (calving intervals, non-return to service rate, culling rate) are more depressed for the t(1; 29) carrier cows than for the mates of carrier bulls (Refsdal, 1976;Dyrendahl and Gustavsson, 1979;Maurer and Vogt, 1988). Moreover, the study of Schmutz et al (1991) indicated that the percentage of unbalanced embryos is higher if they are produced by carrier cows (36%) than by carrier bulls (19%).…”

Section: Meiotic Segregation Analysis In Cows Carryingmentioning

confidence: 99%

“…Previous studies (Gustavsson, 1969(Gustavsson, , 1971Refsdal, 1976;Dyrendahl and Gustavsson, 1979) demonstrated the negative effect (3-5%) of this translocation on reproductive performance of both male and female heterozygotes. By using the sperm-FISH technique our recent study revealed that, on average, 97.1% of spermatozoa were normal or balanced in the semen of t(1; 29) carrier bulls (Bonnet-Garnier et al, 2006).…”

Section: Meiotic Segregation Analysis In Cows Carryingmentioning

confidence: 99%

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Meiotic segregation analysis in cows carrying the t(1;29) Robertsonian translocation

Bonnet-Garnier

Lacaze²,

Beckers

et al. 2008

Cytogenet Genome Res

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Heterozygous carriers of Robertsonian translocations generally have a normal phenotype but present reproductive failure. In cattle, the t(1;29) Robertsonian translocation is very common and carriers show a 3–5% decrease in fertility. Some data suggest that female carriers have a higher decrease than male carriers but no direct studies of the chromosome content of oocytes from a t(1;29) carrier cow have been performed so far. Four heterozygous carrier cows underwent hormonal stimulations and follicles punctions and about 800 oocytes were matured in vitro. Six hundred metaphase II preparations were obtained and analysed by fluorescent in situ hybridization with bovine chromosome 1 and 29 painting probes. Proportions of different kinds of oocytes were assessed: 74.11% (292/394) were normal and balanced, 4.06% (16/394) unbalanced and 21.83% (86/394) diploid. For all cows, the number of normal oocytes was not significantly different from the number of translocated oocytes but the diploidy and unbalanced rate were significantly different between them. As found in bulls, the meiotic segregation pattern in cows has shown a preponderance of alternate products. However, the frequency of unbalanced gametes determined in females (4.06%) was significantly higher than the frequency observed in males (2.76%). The divergence in the rate of diploid gametes (0.04% vs. 21.83%) is mainly explained by the difference between males and females.

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Section: Meiotic Segregation Analysis In Cows Carryingmentioning

confidence: 99%

Section: Meiotic Segregation Analysis In Cows Carryingmentioning

confidence: 99%

Meiotic segregation analysis in cows carrying the t(1;29) Robertsonian translocation

Bonnet-Garnier

Lacaze²,

Beckers

et al. 2008

Cytogenet Genome Res

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“…taurus). Numerous studies provide evidence for the role of Robertsonian translocations in reduced fertility (in vitro: Kawarsky et al 1996, Rubes et al 1999, in vivo: Gustavsson 1969, Dyrendahl and Gustavsson 1979, Rangel-Figueiredo and Iannuzzi 1991. Despite being phenotypically normal, translocation carriers experience a decrease in reproductive potential, predominantly due to the production of chromosomally unbalanced gametes which, subsequent to fertilization, result in early embryonic death (Popescu 1990).…”

Section: Resultsmentioning

confidence: 99%

Robertsonian Translocation [56,XX and 57,XY,rob(1;29)] in Captive Thai Gaur (Bos gaurus readei) by Conventional, GTG-Banding, CBG-Banding and Ag-NOR Banding Techniques

et al. 2011

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SummaryRobertsonian translocation, or centric fusion, which is known to be the most common mechanism in karyotype evolution of bovid species, was observed and described in captive Thai gaur (Bos gaurus readei). Blood samples were taken from 2 male and 2 female captive Thai gaur. After the standard whole blood lymphocyte culture in the presence of colchicine, the metaphase spreads were performed on microscopic slides and air-dried. Conventional staining, GTG-banding, CBGbanding and Ag-NOR banding techniques were applied to stain the chromosomes. The number of diploid chromosomes (2n) were 57 in 2 males and 56 in 2 females instead of the normal 2nϭ58. The fundamental number (NF) was 62 in both the 2 males and 2 females. The autosome consists of 3 submetacentric and 52 telocentric chromosomes in males, and 4 submetacentric and 50 telocentric chromosomes in females. The X chromosome was a large submetacentric chromosome and the Y chromosome was the smallest metacentric chromosome. Eight telocentric chromosomes and 2 submetacentric chromosomes (5 autosome pairs) were identified as satellite chromosomes which showed clearly observable nucleolar organizer regions (NORs). The presence of an extra submetacentric chromosome and the loss of 2 telocentric chromosomes [57,XY,rob(1;29)] were observed in both males. Also, the presence of 2 extra submetacentric chromosomes and the loss of 4 telocentric chromosomes [56,XX,rob(1;29)] were observed in both females. Results from the GTGbanding and CBG-banding techniques analyses confirmed that the 2 autosomes of male (2nϭ57) and 4 autosomes of female (2nϭ56) involved in the translocation are the chromosome pairs 1 and 29, which are common in translocation of the bovid species.

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“…Deviations of the non-return rate of cows, daughters of translocation carriers, could be attributable to early embryonic mortality due to unbalanced chromosome sets of the zygote forming gametes. Although chromosomally unbalanced gametes were produced for 1; 29 carrier bulls (Logue and Harvey, 1978), no deviation of their semen picture was suggested (Dyrendahl and Gustavsson, 1979). Synaptonemal complex analysis of the 1; 29 translocation and more recent mitotic chromosome analyses have demonstrated that the chromosome event in question could involve more than one structural chromosome rearrangement (Di Meo et al, 2006).…”

Section: Pairing Failure Of Translocated Chromosomes: Cause or Effectmentioning

confidence: 99%

Chromosomal abnormalities, meiotic behavior and fertility in domestic animals

Villagómez

Pinton²

2008

Cytogenet Genome Res

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Since the advent of the surface microspreading technique for synaptonemal complex analysis, increasing interest in describing the synapsis patterns of chromosome abnormalities associated with fertility of domestic animals has been noticed during the past three decades. In spite of the number of scientific reports describing the occurrence of structural chromosome abnormalities, their meiotic behavior and gametic products, little is known in domestic animal species about the functional effects of such chromosome aberrations in the germ cell line of carriers. However, some interesting facts gained from recent and previous studies on the meiotic behavior of chromosome abnormalities of domestic animals permit us to discuss, in the frame of recent knowledge emerging from mouse and human investigations, the possible mechanism implicated in the well known association between meiotic disruption and chromosome pairing failure. New cytogenetic techniques, based on molecular and immunofluorescent analyses, are allowing a better description of meiotic processes, including gamete production. The present communication reviews the knowledge of the meiotic consequences of chromosome abnormalities in domestic animals.

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Sexual functions, semen characteristics and fertility of bulls carrying the 1/29 chromosome translocation

Cited by 72 publications

References 9 publications

Meiotic segregation analysis in cows carrying the t(1;29) Robertsonian translocation

Meiotic segregation analysis in cows carrying the t(1;29) Robertsonian translocation

Robertsonian Translocation [56,XX and 57,XY,rob(1;29)] in Captive Thai Gaur (Bos gaurus readei) by Conventional, GTG-Banding, CBG-Banding and Ag-NOR Banding Techniques

Chromosomal abnormalities, meiotic behavior and fertility in domestic animals

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