Sexual Maturation in the Female: Normal Development and Precocious Puberty

Reiter, Edward O.; Kulin, Howard E.

doi:10.1016/s0031-3955(16)32740-7

Cited by 23 publications

(7 citation statements)

References 73 publications

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“…The variable period between the onset of breast development and further progression of other pubertal manifestations in idiopathic precocious puberty (27,39) make borderline responses such as that in our patient AM (Table 4) difficult to interpret. Continuing clinical evaluation and sequential LRF testing may be needed in such cases.…”

Section: Discussionmentioning

confidence: 74%

Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

et al. 1975

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Section: Discussionmentioning

confidence: 74%

Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

et al. 1975

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“…Very early reports showed that children with PA were essentially normal, but some cited studies with an increased incidence of mental retardation. 49,50 We found that, compared with peers in on-time adrenarche, children with PA had more psychological abnormalities that met diagnostic criteria, more self-reported depressive symptoms, more behavior problems, and lower cognitive functioning when controlling for SES. However, from an endocrine perspective, children in the PA group represent outliers in the normal distribution of puberty.…”

Section: Psychological and Cognitive Differencesmentioning

confidence: 74%

Biopsychological and Cognitive Differences in Children With Premature vs On-Time Adrenarche

Dorn

Hitt

Rotenstein

1999

Arch Pediatr Adolesc Med

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Background: Puberty consists of 2 components: gonadarche and adrenarche. Both components have distinct endocrine changes. Adrenarche has virtually been ignored with respect to examining hormone-behavior relations. Objectives: To provide descriptive biological and behavioral information on children with premature adrenarche (PA) and to examine differences in biological, psychological, and cognitive variables of children with PA and a healthy comparison group of children with ontime adrenarche. Design: Descriptive pilot study. Setting: A consecutive sample of patients was recruited from pediatric endocrine clinics; comparison children were recruited from the community. Participants: Children aged 6 to 9 years. Mean (±SD) age of children with PA (n = 9) was 7.8 (±1.3) years; of children with on-time adrenarche (n = 20), 8.0 (±1.2) years. Methods and Measures: Serum and saliva samples were collected for measurement of hormone concentrations. Questionnaires, tests, and interviews were completed by children and parents. Results: Compared with the on-time group, the PA group had significantly higher concentrations of adrenal androgens, estradiol, thyrotropin, and cortisol. By parent report on the Diagnostic Interview Schedule for Children, 4 children (44%) met diagnostic criteria for psychological disorders (primarily anxiety disorders). The PA group also had more self-reported depression and parent-reported behavior problems and lower scores on various intelligence tests. Conclusions: Although PA is considered a normal variation of pubertal development that warrants no medical intervention, PA presents with significant psychosocial problems. Children with PA may need psychological evaluation and follow-up. Future studies should confirm these findings with a larger sample and examine the long-term ramifications of this early presenting abnormality.

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“…Bierich (1975) considers puberty to be precocious when secondary sexual development begins before the age of six and the menarche occurs before the age of eight. Others (Reiter and Kulin, 1972;Dewhurst, 1971) feel that pubertal development is precocious when menstruation occurs before the age of ten and secondary sexual development begins before the age of eight. We have chosen ten years of age as the borderline between physiological and pathological menstruation.…”

Section: Discussionmentioning

confidence: 99%

Vaginal Bleeding in Childhood: A Review of 51 Patients

Heller

Savage

Dewhurst

1978

BJOG

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Summary A search of the medical records at the Hospital for Sick Children, Great Ormond Street and Chelsea Hospital for Women, London, revealed 51 cases of vaginal bleeding in children under the age of 10 occurring in the years 1962 through 1977. The bleeding was caused by some form of precocious puberty in 37 patients (73 per cent). Eight of these patients had cyclical vaginal bleeding in the absence of secondary sexual development or advanced bone age. Fourteen patients (27 per cent) bled because of a local lesion and six of these had a malignant neoplasm of the genital tract.

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Sexual Maturation in the Female: Normal Development and Precocious Puberty

Cited by 23 publications

References 73 publications

Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

Responsivity of Pituitary Gonadotropes to Luteinizing Hormone-releasing Factor in Idiopathic Precocious Puberty, Precocious Thelarche, Precocious Adrenarche, and in Patients Treated with Medroxyprogesterone Acetate

Biopsychological and Cognitive Differences in Children With Premature vs On-Time Adrenarche

Vaginal Bleeding in Childhood: A Review of 51 Patients

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