Sexual Precocity Associated With Hyperplastic Abnormality of the Tuber Cinereum

Bronstein, I. P.; Luhan, Joseph A.; Mavrelis, William B.

doi:10.1001/archpedi.1942.02010080003001

Cited by 20 publications

(6 citation statements)

References 8 publications

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“…Neuronal interconnections between hypothalamic nuclei and hamartoma have been identified [1]. In rare cases, immature neurons or glia cells are included, showing a probable transition to ganglioneuroma, ganglioglioma, or astrocytoma [3,18]. Some have called it hamartoblastoma.…”

Section: Histologymentioning

confidence: 99%

Pubertas praecox and hypothalamic hamartoma

Takeuchi

Handa

1985

Neurosurg. Rev.

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Precocious puberty of cerebral origin is classified into pseudoprecocious puberty and true precocious puberty. Pseudoprecocious puberty is caused by HCG secreting tumours. True precocious puberty is caused by various hypothalamic diseases. Among them, hypothalamic hamartoma is the most common cause. Precocious puberty is caused by elevated blood pituitary gonadotropin concentration, secondary to the elevated hypothalamic LHRH secretion. The hypothalamic hamartoma is not infrequently associated with laughing (gelastic) seizures as well as convulsions. Diagnosis of a hypothalamic hamartoma is easily made by CT. Although the hypothalamic hamartoma is difficult to operate on, the value of surgery is stressed for treatment of precocious puberty. This is also confirmed by recent reports.

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Section: Histologymentioning

confidence: 99%

Pubertas praecox and hypothalamic hamartoma

Takeuchi

Handa

1985

Neurosurg. Rev.

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“…sharp-edged mass in the suprasellar and interpeduncular cisterns, producing mild displacement and without infiltrating features. Some cases have been reported where this investiga tion yielded false-negative results [4,7,8,17,25], but we think this can be overcome by combining polydirectional tomograms, as in our case 1. The angiographic study of Willis' vessels is the rule when surgery is being considered, but it is of little or no value for the diagnosis.…”

Section: Discussionmentioning

confidence: 69%

Hamartomas of the Tuber cinereum and Precocious Puberty

Frank¹,

Cacciari

Cristi

et al. 1982

Pediatr Neurosurg

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“…Most of these are myelinated and occur in small groups but they may form large bundles and tracts passing from the hamartoma through the tissue bridge into the hypothalamus as described by Richter (1951). In the boy aged 3 described by Driggs and Spatz (1939) and in the 22-month-old girl described by Bronstein, Luhan, and Mavrelis (1942) myelinated fibres were present but there was no passage between the hamartoma and the tuber cinereum.…”

Section: Discussionmentioning

confidence: 88%