Sexual precocity: sex incidence and aetiology.

Bridges, Nicola; Christopher, John; Hindmarsh, Peter C.; Brook, C. G. D.

doi:10.1136/adc.70.2.116

Cited by 127 publications

(90 citation statements)

References 5 publications

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“…A similar finding has been reported in previous studies in Nigeria 6,11 . Reports from other parts of Africa and the world indicate that thyroid disorders [13][14][15][16] , overweight and obesity 17 , and precocious puberty 18 are all more common in girls than boys. These specific childhood and adolescence endocrine disorders were among the leading five types of endocrine disorders found in our series.…”

Section: Discussionmentioning

confidence: 99%

Paediatric endocrine disorders as seen at the University of Benin Teaching Hospital over a ten-year period

Onyiriuka¹,

Kouyaté²

2014

Nig. J. Paed.

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Background: In most developing countries, data on the prevalence and distribution of paediatric endocrine disorders is lacking. Objective: To describe the pattern of endocrine disorders seen in the Department of Child Health, University of Benin Teaching Hospital (UBTH), Benin City, Nigeria between 2004 to 2013. Methods: In this retrospective study, the case files of children seen in the paediatric endocrinemetabolic clinic and those admitted into the wards at the UBTH, Benin City from January, 2004 to December, 2013 were audited. Information obtained included age at presentation, gender, principal complaints, and final diagnosis. For those who were admitted, the outcome was noted. The hospital's paediatric clinic register was examined to obtain the total number of new cases seen during the period under review.Results: A total of 13,735 new cases were seen in the Department of Child Health, UBTH during the ten-year period under review and 99 (0.72%) of these had endocrine disorders. The frequencies of the four leading groups of endocrine disorders seen were as follows: diabetes mellitus 17.2%; disorders of sex development 13.8%; disorders of the thyroid gland 12.1%; and disorders of energy balance 11.2%. Short stature was a rare presenting complaint. Conclusion: Diabetes mellitus and disorders involving sex development, thyroid gland, energy balance and pubertal development were the five leading groups of childhood endocrine disorders encountered in our clinical practice in UBTH.

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Section: Discussionmentioning

confidence: 99%

Paediatric endocrine disorders as seen at the University of Benin Teaching Hospital over a ten-year period

Onyiriuka¹,

Kouyaté²

2014

Nig. J. Paed.

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“…CPP is gonadotropin-dependent early maturation and results primarily from activation of HPGA, whereas PPP is gonadotropin-independent; the causes of PPP include both endogenous sources such as gonadal tumors, adrenal tumors, and congenital disorders and exposure to exogenous steroids (5). Gonadotropin-releasing hormone (GnRH), which is produced in the hypothalamus and acts on the pituitary gland, stimulates the pulsatile production and release of gonadotropins including luteinizing hormones (LH) and follicle-stimulating hormones (FSH) to maintain normal reproductive functions (1).…”

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confidence: 99%

“…PP can be divided into two types, central precocious puberty (CPP, also called "true precocious puberty") and peripheral precocious puberty (PPP, or "pseudo precocious puberty"), depending on whether or not the HPGA is involved (5). CPP is gonadotropin-dependent early maturation and results primarily from activation of HPGA, whereas PPP is gonadotropin-independent; the causes of PPP include both endogenous sources such as gonadal tumors, adrenal tumors, and congenital disorders and exposure to exogenous steroids (5).…”

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confidence: 99%

Urinary Metabolite Markers of Precocious Puberty

Пин

Zhang

et al. 2012

Molecular & Cellular Proteomics

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The incidence of precocious puberty (PP, the appearance of signs of pubertal development at an abnormally early age), is rapidly rising, concurrent with changes of diet, lifestyles, and social environment. The current diagnostic methods are based on a hormone (gonadotropin-releasing hormone) stimulation test, which is costly, time-consuming, and uncomfortable for patients. The lack of molecular biomarkers to support simple laboratory tests, such as a blood or urine test, has been a long standing bottleneck in the clinical diagnosis and evaluation of PP. Here we report a metabolomic study using an ultra performance liquid chromatography-quadrupole time of flight mass spectrometry and gas chromatography-time of flight mass spectrometry. Urine metabolites from 163 individuals were profiled, and the metabolic alterations were analyzed after treatment of central precocious puberty (CPP) with triptorelin depot. A panel of biomarkers selected from >70 differentially expressed urinary metabolites by receiver operating characteristic and logistic regression analysis provided excellent predictive power with high sensitivity and specificity for PP. The altered metabolic profile of the PP patients was characterized by three major perturbed metabolic pathways: catecholamine, serotonin metabolism, and tricarboxylic acid cycle, presumably resulting from activation of the sympathetic nervous system and the hypothalamic-pituitary-gonadal axis. Treatment with triptorelin depot was able to normalize these three altered pathways. Additionally, significant changes in the urine levels of 4-hydroxyphenylacetic acid, 5-hydroxyindoleacetic acid, indoleacetic acid, 5-hydroxytryptophan, and 5-hydroxykynurenamine in the CPP group suggest that the development of CPP condi-

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“…A distribuição de acordo com o sexo (meninas para meninos) é estimada em 3:1 (25) e 23:1 (26). A distribuição entre as formas idiopática e orgânica varia largamente: 69 a 98% de casos idiopáti-cos em meninas e 0 a 60% em meninos.…”

Section: Epidemiologiaunclassified

Crescimento em meninos e meninas com puberdade precoce

Silva¹,

Adan²

2003

Arq Bras Endocrinol Metab

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Arq Bras Endocrinol Metab vol 47 nº 4 Agosto 2003 422 RESUMOO desenvolvimento puberal acompanha-se de aceleração da velocidade de crescimento, secundária à elevação dos esteróides sexuais, do hormônio de crescimento e do IGF-1. O número de centímetros ganhos nesse período representa 16% da estatura adulta. A puberdade precoce (PP) pode levar à fusão prematura da cartilagem de crescimento, reduzindo a duração do crescimento e a estatura final. Assim, o principal objetivo do tratamento frenador da PP é evitar o comprometimento estatural. É importante ressaltar que a PP não evolui uniformemente, podendo ter curso lento (slow evolutive form) e não requerer tratamento. Os autores abordam aspectos do crescimento puberal normal, da puberdade precoce e suas variantes, destacando os efeitos do tratamento com GnRHa (análogos de GnRH) na estatura adulta. Situações especiais, como as puberdades avançada e acelerada, são também discutidas. ABSTRACT Growth in Boys and Girls with Precocious Puberty.Pubertal development is associated with increased growth velocity secondary to the interaction of three hormones: sex steroids, growth hormone and IGF-1. The pubertal spurt represents 16% of adult height. Precocious puberty (PP) may induce early fusion of growth plates, reducing growth duration and, consequently, adult height. Thus, the main objective of the treatment with GnRH analogues is to avoid the height commitment. It is important to emphasize that PP does not evolve uniformly, sometimes having a slow course (slow evolutive form), which does not require treatment. The authors discuss aspects of normal pubertal growth, precocious puberty and its variants, and the effects of treatment on final height. Special situations as early and fast puberty are also mentioned. Keywords: Precocious puberty; Early puberty; Fast puberty; Growth; GnRH analogues A PUBERDADE É O PERÍODO DE TRANSIÇÃO entre a infância e a idade adulta, durante o qual os caracteres sexuais secundários aparecem, o estirão puberal ocorre, e profundas mudanças psicológicas acontecem. Ao final dessa fase, o indivíduo está apto para a reprodução. O mecanismo neuro-endócrino responsável pelo desencadeamento da puberdade não está totalmente esclarecido, mas evidências sugerem que aminoácidos com ações inibidoras ou estimuladoras estão envolvidos no processo. Acredita-se que o glutamato desempenha um papel facilitador, enquanto o ácido gama-amino-butírico (GABA) exerce uma ação inibidora (1,2). O fator de crescimento transformante α (TGF α, transforming growth factor) e as IGFs (insulin-like growth factors) revisão Crescimento em Meninos e Meninas Com Puberdade Precoce

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Sexual precocity: sex incidence and aetiology.

Cited by 127 publications

References 5 publications

Paediatric endocrine disorders as seen at the University of Benin Teaching Hospital over a ten-year period

Paediatric endocrine disorders as seen at the University of Benin Teaching Hospital over a ten-year period

Urinary Metabolite Markers of Precocious Puberty

Crescimento em meninos e meninas com puberdade precoce

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