AimsThis qualitative study aimed to explore what it is like for trans and non‐binary (TNB) person‐centred therapists to be exposed to transprejudice in their client work, and how they navigate such relationships. In so doing, the study aims to amplify TNB perspectives, encourage better allyship from cisgender colleagues, workplaces and professional bodies, and inform understandings of person‐centred theory and practice.MethodFive White, TNB, person‐centred therapists took part in non‐directive interviews. A reflexive thematic analysis was performed with a phenomenological and hermeneutical approach.FindingsTherapists perceived their encounters with transprejudice in client work to be infrequent or less intense than in other areas of their lives. Clients who expressed transprejudice were seen as situated in a transprejudiced context, which allowed the therapists to maintain unconditional positive regard and empathy. The therapists nonetheless reported an adverse effect on their well‐being, which required proactive support from peers.ImplicationsThis study demonstrates the need for cisgender colleagues of TNB therapists to be sensitive to the dynamics of transprejudice. Further research is necessary to elucidate the role of internalised transprejudice in shaping TNB therapists' understandings of their person‐centred practice. Further research is also required to account for the range of identities and backgrounds in the TNB community.