Sexuality in women with endometriosis: a critical narrative review

Rosa, Valentina Lucia La; Franciscis, Pasquale De; Barra, Fabio; Schiattarella, Antonio; Tropea, Alessandro; Shah, Mohsin; Kahramanoğlu, İlker; Cerentini, Taís Marques; Ponta, Marco; Ferrero, Simone

doi:10.23736/s0026-4806.19.06299-2

Cited by 35 publications

(39 citation statements)

References 92 publications

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“…The live birth rates per cycle were comparable between the two groups, but the cumulative live birth rate was significantly lower in women with endometriosis as a consequence of the lower number of frozen embryos. Endometriosis remains a complex disease that impairs quality of life [1][2][3] and women's fertility and can impact the outcomes of assisted reproductive technologies in more than one way. Further studies are needed to improve our understanding of these mechanisms in light of the disease's potential heterogeneity, in order to improve the management and the treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…It can affect several anatomical sites such as the ovaries, the peritoneum, the bladder and the rectum. This disease is associated with infertility, dysmenorrhea, and chronic pelvic pain and can impair quality of life in more than one way [1][2][3]. The prevalence of endometriosis is difficult to evaluate in the general population, but best estimates conclude that approximately 10% of women of reproductive age are afflicted with endometriosis [4].…”

Section: Introductionmentioning

confidence: 99%

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Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

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Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

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“…As an obvious consequence, important social and healthcare direct and indirect costs should be also considered and possibly avoided. For the correct management of both pathology and quality of life, we retain that a holistic approach could be of clinical importance and should include regular follow-up of the mental and physical status of affected women and also advices on the adoption of adapta-DOI: 10.1159/000508225 tive/constructive coping strategies (physical fitness, rest, yoga, equilibrate diets, massage, acupuncture, warm baths, or heating pads) to better handle the pain, improve overall sexual functioning, and restore own self-appraisal [31][32][33].…”

Section: Discussion/conclusionmentioning

confidence: 99%

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report

Santoro

Angelico

Inzani

et al. 2020

Gynecol Obstet Invest

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• Endometriosis is the land for any histological type of tumor found in the endometrium with a malignant transformation rate variable from 0.7 to 1.6%. • Recently, sequencing studies have clearly defined a clonal relationship between endometriosis and its malignant counterparts, confirming that the cancers can arise from the adjacent endometriotic focus. Novel Insights • This case represents the first evidence in the literature of the simultaneous occurrence of clear-cell ovarian carcinoma (CCC) and low-grade uterine-extrauterine endometrial stromal sarcoma (LG-ESS) arising in the background of ovarian and pelvic endometriosis. • The present case, staged as FIGO IC for the ovarian neoplasm and IIIA for the LG-ESS, represents a clinical and pathological challenge, especially in terms of surgical staging and patient management.

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“…Laparoscopy is considered the gold standard for the diagnosis and treatment of ectopic endometrial-like implants [3,8], however, 40% of treated women refer to a recurrence of the symptoms within five years [9][10][11][12], especially without post-operative pharmacological treatments [2,13,14]. Furthermore, endometriosis symptoms are often associated with a significant impairment in psychological wellbeing [15,16], that has also a substantial impact on the quality of life [17,18]. Several different theories have been developed in order to justify the etiopathology of endometriosis; although the theory of retrograde menstruation [19,20], developed by Sampson, was widely accepted several years ago, to date, accumulating evidence suggests a key role of genetics, epigenetics, and immune mechanisms for the onset and progression of the disease [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Riemma

Laganà

Schiattarella

et al. 2020

IJMS

Self Cite

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Background: Ion channels play a crucial role in many physiological processes. Several subtypes are expressed in the endometrium. Endometriosis is strictly correlated to estrogens and it is evident that expression and functionality of different ion channels are estrogen-dependent, fluctuating between the menstrual phases. However, their relationship with endometriosis is still unclear. Objective: To summarize the available literature data about the role of ion channels in the etiopathogenesis of endometriosis. Methods: A search on PubMed and Medline databases was performed from inception to November 2019. Results: Cystic fibrosis transmembrane conductance regulator (CFTR), transient receptor potentials (TRPs), aquaporins (AQPs), and chloride channel (ClC)-3 expression and activity were analyzed. CFTR expression changed during the menstrual phases and was enhanced in endometriosis samples; its overexpression promoted endometrial cell proliferation, migration, and invasion throughout nuclear factor kappa-light-chain-enhancer of activated B cells-urokinase plasminogen activator receptor (NFκB-uPAR) signaling pathway. No connection between TRPs and the pathogenesis of endometriosis was found. AQP5 activity was estrogen-increased and, through phosphatidylinositol-3-kinase and protein kinase B (PI3K/AKT), helped in vivo implantation of ectopic endometrium. In vitro, AQP9 participated in extracellular signal-regulated kinases/p38 mitogen-activated protein kinase (ERK/p38 MAPK) pathway and helped migration and invasion stimulating matrix metalloproteinase (MMP)2 and MMP9. ClC-3 was also overexpressed in ectopic endometrium and upregulated MMP9. Conclusion: Available evidence suggests a pivotal role of CFTR, AQPs, and ClC-3 in endometriosis etiopathogenesis. However, data obtained are not sufficient to establish a direct role of ion channels in the etiology of the disease. Further studies are needed to clarify this relationship.

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Sexuality in women with endometriosis: a critical narrative review

Cited by 35 publications

References 92 publications

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

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