Ablation morphology affects the quality of laser processing. Therefore, the control of ablation morphology is very important. The influence of spot size combination mode on the ablation morphology of aluminum alloy is studied for the first time. Experimental results show that when the nanosecond laser spot is larger, the ablation morphology looks like a bowl-shape, and there is little solidification near the edge. When the nanosecond laser spot is smaller, the shape of the ablation morphology is similar to a hole, and the protuberance is formed near the edge of the cavity. Through the analysis and simulation of the physical model, the physical mechanism, which describes the influence of the spot size combination mode on the molten pool, is discussed. The research results of this paper have important guiding significance for the control of laser processing effect.