Shaken Baby Syndrome

Matschke, Jakob; Herrmann, Bent; Sperhake, Jan; Körber, Friederike; Bajanowski, Thomas; Glatzel, Markus

doi:10.3238/arztebl.2009.0211

Cited by 33 publications

(13 citation statements)

References 131 publications

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“…In recognized cases, shaken baby syndrome typically results in death or extremely damaging injuries. Up to 30% of babies who are shaken and hospitalized die and as many as 70% of survivors suffer long term impairments [ 31 ]. While shaken baby syndrome is a rare event, each single case is a tragedy and one case too many.…”

Section: Discussionmentioning

confidence: 99%

Infantile Colic—The Perspective of German and Polish Pediatricians in 2020

Sommermeyer

Krauss

Chęcińska-Maciejewska³

et al. 2020

IJERPH

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The objective of the study was to characterize how infantile colic is perceived and managed by German and Polish pediatricians. Data in both countries were collected by using a paper questionnaire with seven questions and predefined and free text fields for the answers. Answers from 160 German and 133 Polish pediatricians were collected. The average of the occurrence rates estimated by both responder groups were at the higher end of published rates. The majority of pediatricians from both countries rated the parental burden caused by infantile colic to be high or very high. Pediatricians’ awareness about the association between infantile colic and maternal depression and premature termination of breastfeeding is relatively well established in both countries. While more than 90% of German pediatricians stated knowledge of infantile colic being a major risk factor for shaken baby syndrome, this knowledge was only declared by half of the Polish responders. Pharmacological interventions, pro-/synbiotics or simethicone, are part of the treatment repertoire of nearly all responding pediatricians. In addition, non-pharmacological interventions (e.g., change of feeding, change of parental behavior) are also among the employed interventions. Results of this study will allow to better design and prioritize communication about infantile colic directed at pediatricians.

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Section: Discussionmentioning

confidence: 99%

Infantile Colic—The Perspective of German and Polish Pediatricians in 2020

Sommermeyer

Krauss

Chęcińska-Maciejewska³

et al. 2020

IJERPH

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“…The true incidence of AHT is probably much higher as many injuries likely go undetected, because minor cases might not be recognized by physicians. Approximately 13-36% of AHT victims die as a result of their injuries ( Matschke et al, 2009 ), and 62%-96% of survivors suffer permanent physical, neurological and mental disabilities ( Lind et al, 2013 ; Matschke et al, 2009 ). Patients often require long-term care and treatment, which pose a major economic burden to the family and society ( Fiske and Hall, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury

Wang

Gao

Shields

et al. 2018

Disease Models &Amp; Mechanisms

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Abusive head trauma (AHT) is the leading cause of death from trauma in infants and young children. An AHT animal model was developed on 12-day-old mice subjected to 90° head extension-flexion sagittal shaking repeated 30, 60, 80 and 100 times. The mortality and time until return of consciousness were dependent on the number of repeats and severity of the injury. Following 60 episodes of repeated head shakings, the pups demonstrated apnea and/or bradycardia immediately after injury. Acute oxygen desaturation was observed by pulse oximetry during respiratory and cardiac suppression. The cerebral blood perfusion was assessed by laser speckle contrast analysis (LASCA) using a PeriCam PSI system. There was a severe reduction in cerebral blood perfusion immediately after the trauma that did not significantly improve within 24 h. The injured mice began to experience reversible sensorimotor function at 9 days postinjury (dpi), which had completely recovered at 28 dpi. However, cognitive deficits and anxiety-like behavior remained. Subdural/subarachnoid hemorrhage, damage to the brain-blood barrier and parenchymal edema were found in all pups subjected to 60 insults. Proinflammatory response and reactive gliosis were upregulated at 3 dpi. Degenerated neurons were found in the cerebral cortex and olfactory tubercles at 30 dpi. This mouse model of repetitive brain injury by rotational head acceleration-deceleration partially mimics the major pathophysiological and behavioral events that occur in children with AHT. The resultant hypoxia/ischemia suggests a potential mechanism underlying the secondary rotational acceleration-deceleration-induced brain injury in developing mice.

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“…Ocular globe and optic nerve trauma may occur in different daily scenarios including falls, motor vehicle accidents 1 , child abuse 2 , sport-related injuries 3 , as well as blasts in military and non-military combat situations 4 . Traumatic optic neuropathy (TON) may result in axon degeneration and retinal ganglion cell (RGC) death leading to profound visual loss.…”

Section: Introductionmentioning

confidence: 99%

Hypothermia Prevents Retinal Damage Generated by Optic Nerve Trauma in the Rat

Rey-Funes

Larráyoz

Contartese

et al. 2017

Sci Rep

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Ocular and periocular traumatisms may result in loss of vision. Hypothermia provides a beneficial intervention for brain and heart conditions and, here, we study whether hypothermia can prevent retinal damage caused by traumatic neuropathy. Intraorbital optic nerve crush (IONC) or sham manipulation was applied to male rats. Some animals were subjected to hypothermia (8 °C) for 3 h following surgery. Thirty days later, animals were subjected to electroretinography and behavioral tests. IONC treatment resulted in amplitude reduction of the b-wave and oscillatory potentials of the electroretinogram, whereas the hypothermic treatment significantly (p < 0.05) reversed this process. Using a descending method of limits in a two-choice visual task apparatus, we demonstrated that hypothermia significantly (p < 0.001) preserved visual acuity. Furthermore, IONC-treated rats had a lower (p < 0.0001) number of retinal ganglion cells and a higher (p < 0.0001) number of TUNEL-positive cells than sham-operated controls. These numbers were significantly (p < 0.0001) corrected by hypothermic treatment. There was a significant (p < 0.001) increase of RNA-binding motif protein 3 (RBM3) and of BCL2 (p < 0.01) mRNA expression in the eyes exposed to hypothermia. In conclusion, hypothermia constitutes an efficacious treatment for traumatic vision-impairing conditions, and the cold-shock protein pathway may be involved in mediating the beneficial effects shown in the retina.

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Shaken Baby Syndrome

Cited by 33 publications

References 131 publications

Infantile Colic—The Perspective of German and Polish Pediatricians in 2020

Infantile Colic—The Perspective of German and Polish Pediatricians in 2020

Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury

Hypothermia Prevents Retinal Damage Generated by Optic Nerve Trauma in the Rat

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