Shaping of Motor Responses by Incentive Values through the Basal Ganglia

Pasquereau, Benjamin; Nadjar, Agnès; Arkadir, David; Bézard, Erwan; Goillandeau, Michel; Bioulac, Bernard; Gross, Christian E.; Boraud, Thomas

doi:10.1523/jneurosci.3745-06.2007

Cited by 107 publications

(123 citation statements)

References 28 publications

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“…We found significant levels of action value signals before animal's choice of action, which is consistent with previous reports on the monkey DS (Samejima et al, 2005;Lau and Glimcher, 2008; also see Pasquereau et al, 2007). Collectively, our results are most consistent with the possibility that the striatum contributes to action selection only indirectly by conveying values associated potential choices and actual action selection takes place elsewhere.…”

Section: Role Of Striatum In Action Selectionsupporting

confidence: 92%

Role of Striatum in Updating Values of Chosen Actions

Kim

Sul²,

Huh³

et al. 2009

J. Neurosci.

195

304

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The striatum is thought to play a crucial role in value-based decision making. Although a large body of evidence suggests its involvement in action selection as well as action evaluation, underlying neural processes for these functions of the striatum are largely unknown. To obtain insights on this matter, we simultaneously recorded neuronal activity in the dorsal and ventral striatum of rats performing a dynamic two-armed bandit task, and examined temporal profiles of neural signals related to animal's choice, its outcome, and action value. Whereas significant neural signals for action value were found in both structures before animal's choice of action, signals related to the upcoming choice were relatively weak and began to emerge only in the dorsal striatum ϳ200 ms before the behavioral manifestation of the animal's choice. In contrast, once the animal revealed its choice, signals related to choice and its value increased steeply and persisted until the outcome of animal's choice was revealed, so that some neurons in both structures concurrently conveyed signals related to animal's choice, its outcome, and the value of chosen action. Thus, all the components necessary for updating values of chosen actions were available in the striatum. These results suggest that the striatum not only represents values associated with potential choices before animal's choice of action, but might also update the value of chosen action once its outcome is revealed. In contrast, action selection might take place elsewhere or in the dorsal striatum only immediately before its behavioral manifestation.

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Section: Role Of Striatum In Action Selectionsupporting

confidence: 92%

Role of Striatum in Updating Values of Chosen Actions

Kim

Sul²,

Huh³

et al. 2009

J. Neurosci.

195

304

View full text Add to dashboard Cite

show abstract

“…This type of information could easily be conveyed to the context-dependent basal ganglia output neurons that we observed to encode information about the relationship between movement and either successful completion or reward. This finding has been further supported in a recent study of putamen and GPi neurons (Pasquereau et al, 2007). Pasquereau and colleagues demonstrated that the basal ganglia output neurons play a role in both encoding information about the context in which a movement is made, but also appear to execute a computation that can be used to assist the selection of a specific action.…”

Section: Possible Factors That May Influence Context-dependent Dischargementioning

confidence: 69%

Signaling patterns of globus pallidus internal segment neurons during forearm rotation

et al. 2007

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We recorded extracellular single unit discharges of globus pallidus internal segment (GPi) neurons in monkeys performing a visually-driven forearm rotation movement task in order to quantify how discharge patterns changed in relation to kinematic parameters. Subjects grasped a handle that rotated about its axis while facing a video screen displaying visual targets. Continuous visual feedback of handle rotation position was provided. Monkeys generated forearm rotation movements of ±35° and ±70° amplitude in order to align the cursor and targets. Trial records were aligned to forearm rotation onset in order to compare the discharge patterns that were associated with movements of different amplitudes, velocities, and directions. In addition, we quantified the depth of modulation of neuronal discharge associated with movements generated in two different task phases. Comparisons of discharge patterns were made between the visually-guided, rewarded phase ("cued movements") and the self-paced, unrewarded phase that returned the monkey to the task start position ("return movements") by quantifying the goodness of fit between neuronal discharge during cued and return movements.Our analyses revealed no systematic relationship between the depth of modulation of GPi neurons and forearm rotation amplitude, direction, or velocity. Further, comparisons between the two behavioral contexts revealed a systematic attenuation of modulation that could not be attributed to differences in movement velocity. Collectively, these findings suggest that the GPi neurons that we studied were not significantly involved in mediating movement kinematics, but may have instead been instrumental in the processing of information about the behavioral context during which movements were generated.

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“…In sum, the expected value of engaging different neuronal populations, dedicated to specific tasks, might be topographically represented in frontostriatal circuits. In primate prefrontal cortex or striatum, certain neuronal activities have been reported to express both expected reward and various task dimensions, such as target location (Watanabe, 1996;Leon and Shadlen, 1999;Kobayashi et al, 2006) or movement direction (Lauwereyns et al, 2002;Matsumoto et al, 2003;Samejima et al, 2005;Pasquereau et al, 2007). However, the topographical organization of neuronal populations encoding expected values, and their connection with the corresponding effectors, remain to be established.…”

Section: Discussionmentioning

confidence: 99%

Brain Hemispheres Selectively Track the Expected Value of Contralateral Options

Palminteri¹,

Boraud²,

Lafargue³

et al. 2009

J. Neurosci.

Self Cite

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A main focus in economics is on binary choice situations, in which human agents have to choose between two alternative options. The classical view is that decision making consists of valuating each option, comparing the two expected values, and selecting the higher one. Some neural correlates of option values have been described in animals, but little is known about how they are represented in the human brain: are they integrated into a single center or distributed over different areas? To address this issue, we examined whether the expected values of two options, which were cued by visual symbols and chosen with either the left or right hand, could be distinguished using functional magnetic resonance imaging. The two options were linked to monetary rewards through probabilistic contingencies that subjects had to learn so as to maximize payoff. Learning curves were fitted with a standard computational model that updates, on a trial-by-trial basis, the value of the chosen option in proportion to a reward prediction error. Results show that during learning, left and right option values were specifically expressed in the contralateral ventral prefrontal cortex, regardless of the upcoming choice. We therefore suggest that expected values are represented in a distributed manner that respects the topography of the brain systems elicited by the available options.

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Shaping of Motor Responses by Incentive Values through the Basal Ganglia

Cited by 107 publications

References 28 publications

Role of Striatum in Updating Values of Chosen Actions

Role of Striatum in Updating Values of Chosen Actions

Signaling patterns of globus pallidus internal segment neurons during forearm rotation

Brain Hemispheres Selectively Track the Expected Value of Contralateral Options

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