Shared Genotypes of
            <i>Achromobacter xylosoxidans</i>
            Strains Isolated from Patients at a Cystic Fibrosis Rehabilitation Center

Daele, S. Van; Verhelst, Rita; Claeys, Geert; Verschraegen, Gerda; Franckx, Hilde; Simaey, Leen Van; Ganck, Catharine Clara De; Baets, Frans De; Vaneechoutte, Mario

doi:10.1128/jcm.43.6.2998-3002.2005

Cited by 55 publications

(63 citation statements)

References 29 publications

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“…In a report about the occurrence of two large clusters of A. xylosoxidans in a CF rehabilitation centre population, the hospital laboratory initially misidentified this organism as P. aeruginosa [31].…”

Section: Resultsmentioning

confidence: 99%

Survey ofPseudomonas aeruginosagenotypes in colonised cystic fibrosis patients

Daele¹

2006

Eur Respir J

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The current authors aimed to examine whether cystic fibrosis (CF) patients in Belgium shared Pseudomonas aeruginosa genotypes and to compare the genotypes of isolates from the same patients during two consecutive years. A Belgian databank of the P. aeruginosa genotypes of all colonised CF patients was created.Sputum samples from a total of 276 P. aeruginosa colonised patients during 2003, and from a subgroup of 95 patients in 2004, were analysed. Patients were asked about any social contact between each other by questionnaire. All P. aeruginosa isolates exhibiting different colonial morphology on McConkey agar were first genotyped using arbitrarily primed PCR, whereafter single representatives of each randomly amplified polymorphic DNA-type were further genotyped by fluorescent amplified fragment length polymorphism analysis.In the 213 patients from whom P. aeruginosa could be cultured (resulting in 910 isolates), a total of 163 genotypes were found. The majority (75%) of patients harboured only one genotype. In most of the limited number of clusters, previous contacts between patients could be suspected. In 80% of the patients studied during both years, P. aeruginosa genotype remained unchanged.In conclusion, most colonised cystic fibrosis patients harbour only one Pseudomonas aeruginosa genotype, despite showing different colonial morphotypes. The number of clusters is limited, and most patients seem to retain the same genotypic strain during both years.

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Section: Resultsmentioning

confidence: 99%

Survey ofPseudomonas aeruginosagenotypes in colonised cystic fibrosis patients

Daele¹

2006

Eur Respir J

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“…The relative frequency of shared strains of different CF pathogens is shown in Table 6. 27,28,30,66,102,[129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145] III.A.1. Burkholderia spp.…”

Section: Iiia Person-to-person Transmission Among People With Cfmentioning

confidence: 99%

“…196 In a multicenter study conducted in Belgium, 2 clusters of A. xylosoxidans strains were identified (one consisted of 4 individuals, and the other consisted of 10 individuals). 144 Thus, there is some evidence of shared strains of A. xylosoxidans and a suggestion of possible patient-to-patient transmission.…”

Section: Iiia3 Other Gram-negative Bacteriamentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

352

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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“…The most common predisposing underlying medical issues observed in the setting of A. xylosoxidans infection are malignancy, both hematologic and solid organ (30%), cardiac disease (21%), and immunosuppression (27%) (3,9,17,18,20). Other documented comorbidities include HIV infection, cystic fibrosis (CF) (10,13,17,33,40), diabetes mellitus (DM) (1, 6), chronic renal failure (CRF) (6), chronic obstructive pulmonary disease (COPD) (12), cirrhosis (17), intravenous drug abuse (41), treatment with high-dose corticosteroids (3), rheumatoid arthritis with immunomodulation therapy (37), and underlying urologic abnormalities (38).…”

Section: Case Reportmentioning

confidence: 99%