Shared Rearing Environment in Migraine: Results From Twins Reared Apart and Twins Reared Together

Svensson, Dan A.; Larsson, Bo; Waldenlind, Elisabet; Pedersen, Nancy L.

doi:10.1046/j.1526-4610.2003.03047.x

Cited by 75 publications

(51 citation statements)

References 36 publications

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“…In this work we replicate previous findings of a major genetic effect for migraine [7][8][9][10][11][12][13][14]. The main genetic and environmental architecture of migraine appears to be remarkably stable across Swedish birth cohorts (Table 5).…”

Section: Discussionsupporting

confidence: 88%

“…Analyses of varying definitions of disease revealed interesting features of the phenotype. First, starting from the most liberal definition of migraine (as measured by diagnosis or self-report), heritability was stable (52%) when cases of self-ascertained migraine without other recurrent headache was considered to Table 4 Variance components (%) for migraine by various definitions of illness and sex with 95% confidence intervals between parentheses IHS, International Headache Society criteria; CATI, Computer Assisted Telephone Interviews; Q, Questionnaire; D*, Non-additive genetic effect is significant as evaluated by means of the chi-square difference test (p<0.05); Age*, age difference in women is significant as evaluated by means of the chi-square difference test (p<0.05) †Additive and non-additive genetic variance (ADE-model) ‡The female-to-male ratio as evaluated by the logistic regression model and computation of odds-ratio 1 Present study; 2 Larsson et al [8]; 3 Svensson et al [12]; 4 Svensson et al [13] be non-affected and decreased the prevalence from 23 to 16%. A change of phenotype definition that lowers the prevalence but does not alter the heritability may reflect an overclassification of disease.…”

Section: Discussionmentioning

confidence: 95%

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Heritability of migraine as a function of definition

et al. 2004

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The objective was to examine the main genetic and environmental architecture of migraine in the Screening Across Lifetime of Twin (SALT) Study as a function of definition. We performed a quantitative genetic study of the Swedish population and a total of 12,095 twin pairs aged 41–64 years were interviewed on the telephone by trained lay personnel using a structured questionnaire. Lifetime assessment of recurrent headache and two measures of migraine were obtained, diagnosis in line with the 1988 International Headache Society criteria and self-report. The lifetime prevalence was 10.3% for diagnosed and 21.4% for self-reported migraine. Among diagnosed cases 82.3% self-reported migraine. Among self-ascertained cases, 60.3% did not fulfil diagnostic criteria, and one third had not had recurrent headache. In multivariate analyses, genetic influences were common to diagnosed and self-reported migraine (42%) and specific to self-report migraine (11%). In univariate analyses, heritability was stable (52%) when “false positives” were removed from the case definition (diagnosed or self-reported migraine) and decreased the prevalence from 23 to 16% but dropped (from 52 to 38%) when “false negatives” were removed and decreased the prevalence from 23 to 17%. A relationship between the definition and the heritability of migraine was demonstrated and phenotypes of clinical and aetiologic relevance were disclosed.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 95%

Heritability of migraine as a function of definition

et al. 2004

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“…SATSA collected information on a total of 351 pairs of twins reared apart (Pedersen et al, 1991). The median age of separation was 2 years, and 75% were separated when they were 5 years old or younger (Svensson et al, 2003). As defined by SATSA, being reared apart referred to separation before 11 years old, but it was also recognized that twins reared apart before the ages of 1, 2, and 5 exhibited a highly skewed distribution, accounting for 52%, 69%, and 82% of all twins reared apart (Kendler et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Utilizing the Resource of Twins Reared Apart: Their Distribution Across Nine Provinces or Cities of China

et al. 2015

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Twins reared apart provide a fascinating experiment to distinguish genetic from environmental influences. However, there is as yet no broad report on distribution of twins reared apart, especially in the Chinese population. In this study, information on 18,295 volunteer twin pairs of all age groups was compiled in nine provinces or cities of China, and questionnaires were used for zygosity determination. It was discovered that twins reared apart from 0 to 10 years of age accounted for 2.2% of all twin interviewees, with the proportion of this 0-10 group separated before 1, 2, and 5 years old, accounting for 65.3%, 76.1%, and 91.3%, respectively. The proportion of twins reared apart is not significantly related to zygosity or gender, but it is related to region and twin age. As the age of twins lowers, the proportion of those reared apart gradually decreases. Twins reared apart will become rarer in the future and therefore should be cherished as a resource.Keywords: twin studies, child rearing, adoption, environment, genes Classical twin design (CTD) estimates the parameters of additive genetic variance (V A ), non-additive genetic variance (V NA ), common environmental effect variance (V C ), and unique environmental effect variance (V E ) by comparing the similarities between monozygotic (MZ) twins and dizygotic (DZ) twins. Apart from these four parameters, the correlation coefficient (r) of DZ twins attributable to non-additive genetic influence is also unidentified (Coventry & Keller, 2005). However, CTD only obtains three observations: total phenotypic variance, MZ phenotypic covariance, and DZ phenotypic covariance. It is obviously impossible to deduce the five parameters from the three observations, since the degree of freedom will be negative when using structural equation models (Ozaki et al., 2011). We therefore must assume r = 1/4 and V C or V NA = 0 to estimate the three other parameters. This is a potential limitation of CTD -bias -and often occurs during parameter estimation since V C and V NA cannot be estimated simultaneously while fixing r at 1/4 (Coventry & Keller, 2005).One way to address the problem is to study twins reared apart, which is an ingenious concept and known as 'the fascinating experiment of nature, the simplest and most powerful method for disentangling the influence of

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“…A large study involving about 30,000 pairs of twins showed that genetics and environmental factors contribute almost equally to the development of migraine [10]. Studies of twins who grew up together or separately showed that general environmental factors play a secondary role [11,12].…”

Section: Inheritance Of Migrainementioning

confidence: 99%

Genetics of Migraine - Is There any Progress?

Klimov¹,

Kondratieva²,

Анучина³

et al. 2017

JNSK

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Nowadays migraine ranks 9th in the list of leading causes of disability among population. In Russia migraine prevalence is two times higher than the world index and inflicts a considerable damage on the state economy. Despite almost one-century history of studying migraine, science until now cannot explain many cases of attack occurrence. It causes difficulties both for diagnosis and treatment -the therapy of patients with migraine is not sufficiently effective. Today one of the investigation directions is searching of migraine biomarkers confirming diagnosis. In this review we attempted to generalize the results of available works targeted at searching genetic markers of migraine.

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Shared Rearing Environment in Migraine: Results From Twins Reared Apart and Twins Reared Together

Abstract: In agreement with previous twin data, family resistance in migraine is mainly due to genetic factors, whereas environmental influences make family members different, not similar.

Cited by 75 publications

References 36 publications

Heritability of migraine as a function of definition

Heritability of migraine as a function of definition

Utilizing the Resource of Twins Reared Apart: Their Distribution Across Nine Provinces or Cities of China

Genetics of Migraine - Is There any Progress?

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