SHARPEN score accurately predicts in-hospital mortality in infective endocarditis

Alves, Sofia Giusti; Júnior, Fernando Pivatto; Filippini, F; Dannenhauer, Gustavo Paglioli; Miglioranza, Marcelo Haertel

doi:10.1016/j.ejim.2021.05.036

Cited by 6 publications

(10 citation statements)

References 7 publications

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“…Including both surgical and non-surgical cohort, the score had a good performance (AUC: 0.76; 95% CI: 0.67-0.85; p < 0.001). 78 Another study by Chee et al, through an 11-year study, also independently correlated with mortality. The score was stratified into low risk (2-6), moderate risk (7-10), and high risk (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) groups, with a good predictive performance (AUC: 0.86; 95% CI: 0.80-0.91; p < 0.001).…”

Section: Sharpenmentioning

confidence: 90%

“…The SHARPEN score includes systolic blood pressure <90 mm Hg at presentation, heart failure, age (with varying score according to the age group: <50, 50–65, and >65 years), renal function (>2.26 mg/dL), pneumonia (⩾48 h after admission), elevated peak CRP (>200 mg/L during hospitalization), and non-intravenous drug abuser. 78 This score was recently validated, in a retrospective study that included 179 hospitalized patients for IE, with variable presentation and complications. This study found a sensitivity of 70.0% and specificity of 71.2%, positive predictive value of 41.1%, and negative predictive value of 89.2% with a score of 10 as a cut-off.…”

Section: Sharpenmentioning

confidence: 99%

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Contemporary risk models for infective endocarditis surgery: a narrative review

Agrawal,

Arockiam,

Jamil

et al. 2023

Therapeutic Advances in Cardiovascular Disease

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Infective endocarditis is a complex heterogeneous condition involving the infection of the endocardium and heart valves, leading to severe complications, including death. Surgery is often indicated in patients with infective endocarditis but is associated with elevated risk compared with other forms of cardiac surgery. Risk models play an important role in many cardiac surgeries as they can help inform clinicians and patients regarding procedural risk, decision-making to proceed or not, and influence perioperative management; however, they remain under-utilized in the infective endocarditis settings. Another crucial role of such risk models is to assess predicted versus found mortality, thereby allowing an assessment of institutional performance in infective endocarditis surgery. Traditionally, general cardiac surgery risk models such as European System for Cardiac Operative Risk Evaluation (EuroSCORE), EuroSCORE II, and Society of Thoracic Surgeon’s score have been applied to endocarditis surgery. However, there has been the development of many endocarditis surgery-specific scores over the last decade. This review aims to discuss clinical characteristics and applications of all contemporary risk scores in the setting of surgical treatment of infective endocarditis.

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Section: Sharpenmentioning

confidence: 90%

Section: Sharpenmentioning

confidence: 99%

Contemporary risk models for infective endocarditis surgery: a narrative review

Agrawal,

Arockiam,

Jamil

et al. 2023

Therapeutic Advances in Cardiovascular Disease

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“…SHARPEN é um escore de risco para EI desenvolvido por Chee et al 11 para predizer mortalidade hospitalar em pacientes operados e não operados. 25 Nosso estudo tem como objetivo avaliar o valor prognóstico do escore SHARPEN durante a internação por EI tanto em pacientes operados como não operados, além de comparar seu desempenho com o Índice de Comorbidade de Charlson (ICC). 26 …”

Section: Introductionunclassified

“…SHARPEN is a risk score for IE developed by Chee et al 11 to predict in-hospital mortality in operated and non-operated patients. 25 Our study aims to prognostic value of SHARPEN score during hospitalization and after discharge in both operated and non-operated patients admitted for IE and to compare its performance with that of the Charlson comorbidity index (CCI). 26 …”

Section: Introductionmentioning

confidence: 99%

Desempenho do Escore SHARPEN e do Índice de Comorbidade de Charlson para Predição de Mortalidade durante a Internação Hospitalar e após a Alta na Endocardite Infecciosa

Alves,

Pivatto,

Filippini

et al. 2023

Arquivos Brasileiros De Cardiologia

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“…IE still represents a significant public health problem in terms of morbidity and mortality. Only a few studies examined predictive factors for mortality in IE [ 11 , 12 , 13 , 14 , 15 , 16 ]. The aim of this study was to assess which risk factors were associated with poorer outcomes in IE patients admitted to an infectious disease unit in Central Italy.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience

Ucciferri

Auricchio

Cutone

et al. 2022

Infectious Disease Reports

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Background: Nowadays, infective endocarditis (IE) is still burdened by a high mortality. In the absence of an adequate prognostic stratification system, it is important to assess new predictors of poor outcomes. The aim of our study is to evaluate which factors were associated with higher mortality in IE patients. Methods: A retrospective cohort study enrolled patients with an IE diagnosis at the Infectious Diseases Clinic of the University ‘G. D’Annunzio’, Chieti, Italy from January 2013 to December 2019. For each patient, demographic, anamnestic and clinical information, embolic phenomena, laboratory and microbiologic data, treatment, and outcomes were collected and analyzed. A correlation analysis was performed. Results: Sixty-eight patients with EI were studied; among them, the mortality was 17.6%, 20.6%, and 23.5%, intra-hospital, at 1 month from discharge and at 6 months from discharge, respectively. Mortality was significantly correlated with age, estimated glomerular filtration rate, and procalcitonin values when considering either basal values (r = 0.266, p = 0.029), or values at 48–72 h from the start of an antibiotic therapy (r = 0.222; p < 0.05), cerebral embolization for 6-month mortality (r = 0.284; p = 0.019), and inadequate antibiotic therapy (r = 0.232, p < 0.05). Conclusions: Procalcitonin values, at EI diagnosis and at 48–72 h after starting antibiotics, are prognostic factors useful for stratifying patient risk, and for setting up a personalized treatment. Of note, cerebral embolization and an inappropriate empirical treatment were associated with a higher mortality in the short- and long-term.

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SHARPEN score accurately predicts in-hospital mortality in infective endocarditis

Cited by 6 publications

References 7 publications

Contemporary risk models for infective endocarditis surgery: a narrative review

Contemporary risk models for infective endocarditis surgery: a narrative review

Desempenho do Escore SHARPEN e do Índice de Comorbidade de Charlson para Predição de Mortalidade durante a Internação Hospitalar e após a Alta na Endocardite Infecciosa

Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience

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