Shaved margin histopathology and imprint cytology for assessment of excision in canine mast cell tumors and soft tissue sarcomas

Abstract

Imprint cytology and shaved margin histopathology are feasible, but their results are frequently disparate from routine radial section histopathology. Future studies are needed to evaluate the correlation of each method with local recurrence rates.

Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties

“…The 16 observers completed the practice test in a median of 8 days (range, 1-13) after the training and completed the data set in a median of 13.5 days (range, [9][10][11][12][13][14] days after the training.…”

“…Such techniques include intraoperative cytology, shave margins, near-infrared fluorescent imaging, and optical coherence tomography (OCT). [7][8][9][10][11][12][13] These investigations have largely involved feasibility and have been pilot studies in nature because no large-scale clinical trials have been performed. An imaging modality that can be used to evaluate intraoperative surgical margin status is critical to improving the accuracy and efficacy of cancer surgery in companion animal species.…”

“…Very few reports have focused on intraoperative real‐time techniques for assessment of surgical margins in dogs. Such techniques include intraoperative cytology, shave margins, near‐infrared fluorescent imaging, and optical coherence tomography (OCT) 7‐13 . These investigations have largely involved feasibility and have been pilot studies in nature because no large‐scale clinical trials have been performed.…”

Histologic processing artifacts and inter-pathologist variation in measurement of inked margins of canine mast cell tumors

“…Specimens for margin measurement were taken from a population of dogs prospectively recruited for a larger clinical trial published elsewhere. 13 All patients had been presented to Lois Bates Acheson Veterinary Teaching Hospital at Oregon State University (Corvallis, OR) over a consecutive 10-mo period (August 2014–June 2015). Inclusion criteria were dogs undergoing planned surgical excision of a cytologically diagnosed cutaneous or subcutaneous MCT, with en bloc removal of a grossly normal surgical margin of ≥1 mm (i.e., no grossly visible tumor at the surgical margins).…”

Comparison of histologic margin status in low‐grade cutaneous and subcutaneous canine mast cell tumours examined by radial and tangential sections

“…Dogs presenting to Oregon State University Lois Acheson‐Bates Veterinary Teaching Hospital were prospectively recruited over a consecutive 24‐month period (August 1, 2014‐July 31, 2016). Patients represented a subset of a larger clinical study evaluating an independent research question published elsewhere, but with sufficient remaining formalin‐fixed tissues for the addition of tangential sections . Inclusion criteria were dogs undergoing planned surgical excision of a cytologically diagnosed cutaneous or subcutaneous MCT, with en bloc removal of a grossly normal surgical margin (GNSM) of at least 1 mm (ie, no grossly visible tumour at the surgical margins).…”