Shear-induced platelet activation and platelet microparticle formation in native human blood

Sakariassen, Kjell S.; Holme, Pl A.; Ørvim, U.; Barstad, R. M.; Solum, Nils Olav; Brosstad, Frank

doi:10.1016/s0049-3848(98)00158-3

Cited by 65 publications

(41 citation statements)

References 23 publications

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“…The high shear at vascular stenotic sites, including those due to constriction from grafts or intraluminal devices, affects neutrophil and monocyte adherence and phagocytosis 21,22 without impeding, and possibly increasing, microbial adherence. 23 These deleterious effects on endothelial cells, platelets, 24 and cell-mediated immunity may have important etiologic roles with regard to establishment and maintenance of device infection.…”

Section: Host Response To Medical Devicesmentioning

confidence: 99%

“…The LVAD induces iatrogenic immunodeficiency that may predispose to infection. 24,[77][78][79][80][81][82] The device induces an aberrant state of T-cell activation that leads to programmed cell death among CD4-bearing T cells. This results in progressive defects in cellular immunity that may predispose to certain types of infection, including fungal infections.…”

Section: Left Ventricular Assist Devicesmentioning

confidence: 99%

“…This results in progressive defects in cellular immunity that may predispose to certain types of infection, including fungal infections. In one case-control analysis 24 the risk of developing disseminated candidiasis was markedly increased (28% versus 3%; Pϭ0.003) in LVAD recipients as compared with control patients who received medical management and no LVAD placement. Moreover, the LVAD recipients had cutaneous anergy to intradermally injected recall antigens and lower T-cell proliferative responses than control patients did after activation via the T-cell receptor complex.…”

Section: Left Ventricular Assist Devicesmentioning

confidence: 99%

See 2 more Smart Citations

Nonvalvular Cardiovascular Device–Related Infections

Baddour¹,

Bettmann²,

Bolger³

et al. 2003

Circulation

447

326

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Section: Host Response To Medical Devicesmentioning

confidence: 99%

Section: Left Ventricular Assist Devicesmentioning

confidence: 99%

Section: Left Ventricular Assist Devicesmentioning

confidence: 99%

See 1 more Smart Citation

Nonvalvular Cardiovascular Device–Related Infections

Baddour¹,

Bettmann²,

Bolger³

et al. 2003

Circulation

447

326

View full text Add to dashboard Cite

“…found that shear rates above certain threshold values seem to promote thrombus formation [30,31], and that various features of turbulent flow also might influence [32]. Turbulent flow has also been suggested to have additional degenerative effects on blood, which is commented more in the appended papers.…”

Section: Thrombus Formationmentioning

confidence: 95%

Turbulent Flow in Constricted Blood Vessels : Quantification of Wall Shear Stress Using Large Eddy Simulation

Gårdhagen¹

2013

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No part of this publication may be reproduced, stored in a retrieval system, or be transmitted, in any form or by any means, electronic, mechanic, photocopying, recording, or otherwise, without prior permission of the author.Cover: Pipe flow becomming turbulent after a constriction. Streamlines, wall shear stress on the surface, and vorticity in three cross sections. AbstractThe genesis of atherosclerosis has previously been shown to be affected by the frictional load from the blood on the vessel wall, called the wall shear stress (WSS). Assessment of WSS can therefore provide important information for diagnoses, intervention planning, and follow-up. Calculation of WSS requires highresolved velocity data from the vessel, which in turn can be obtained using computational fluid dynamics (CFD). In this work large eddy simulation LES was successfully used to simulate transitional flow in idealized as well as subject specific vessel models. It was shown that a scale resolving technique is to prefer for this application, since much valuable information otherwise is lost. Besides, Reynolds-Averaged Navier-Stokes (RANS) models have generally failed to predict this type of flow.Non-pulsating flows of Reynolds numbers up to 2 000 in a circular constricted pipe showed that turbulence is likely to occur in the post-stenotic region, which resulted in a complex WSS pattern characterized by large spatial as well temporal fluctuations in all directions along the wall. Time averaged streamwise WSS was relatively high, while time averaged circumferential WSS was low, meaning that endothelial cells in that region would be exposed to oscillations in a stretched state in the streamwise direction and in a relaxed state in the circumferential direction.Since every vessel is unique, so is also its WSS pattern. Hence the CFD simulations must be done in subject specific vessel models. Such can be created from anatomical information acquired with magnetic resonance imaging (MRI). MRI can also be used to obtain velocity boundary conditions for the simulation. This technique was used to investigate pulsating flow in a subject specific normal human aorta. It was shown that even the flow in healthy vessels can be very disturbed and turbulence like, and even for this case large WSS variations were seen. It was also shown that regions around branches from the aorta, known to be susceptible for atherosclerosis, were characterized by high time averaged WSS and high oscillatory shear index.Finally, the predictive capability of CFD was investigated. An idealized model of a human aorta with a coarctation and post-stenotic dilatation was studied before and after a possible repair of the constriction. The results suggested that iii small remaining abnormalities in the geometry may deteriorate the chances for a successful treatment. Also, high values of shear rate and Reynolds stresses were found in the dilatation after the constriction, which previous works have shown means increased risk for thrombus formation and hemolysis. iv Populärvetenskaplig be...

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“…This describes the expression of adhesion molecules on the surface of platelets (activation) in response to HIFU exposure and clumping (aggregation) in the absence of triggers from endothelial damage, occurring up to 50 s after initial HIFU exposure. It is known that platelets can be activated in the absence of tissue damage by shear stresses on their surface [64], and in the studies by Poliachik, aggregation occurred in response to acoustic cavitation. This is thought to be due to microstreaming causing shear stresses on the surface of the platelets which are sufficient to cause activation and aggregation but insufficient to cause disruption of the membrane [65].…”

Section: Effect Of High-intensity Focused Ultrasound On Thrombogenesismentioning

confidence: 99%

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

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ReviewCite this article: Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC. 2014 Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery. J. R. Soc. High-intensity focused ultrasound (HIFU) is a non-invasive technology, which can be used occlude blood vessels in the body. Both the theory underlying and practical process of blood vessel occlusion are still under development and relatively sparse in vivo experimental and therapeutic data exist. HIFU would however provide an alternative to surgery, particularly in circumstances where serious complications inherent to surgery outweigh the potential benefits. Accordingly, the HIFU technique would be of particular utility for fetal and placental interventions, where open or endoscopic surgery is fraught with difficulty and likelihood of complications including premature delivery. This assumes that HIFU could be shown to safely and effectively occlude blood vessels in utero. To understand these mechanisms more fully, we present a review of relevant cross-specialty literature on the topic of vascular HIFU and suggest an integrative mechanism taking into account clinical, physical and engineering considerations through which HIFU may produce vascular occlusion. This model may aid in the design of HIFU protocols to further develop this area, and might be adapted to provide a non-invasive therapy for conditions in fetal medicine where vascular occlusion is beneficial.

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Shear-induced platelet activation and platelet microparticle formation in native human blood

Cited by 65 publications

References 23 publications

Nonvalvular Cardiovascular Device–Related Infections

Nonvalvular Cardiovascular Device–Related Infections

Turbulent Flow in Constricted Blood Vessels : Quantification of Wall Shear Stress Using Large Eddy Simulation

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

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