Sheep Immunology and Goat Peculiarities

doi:10.1016/b978-012546401-7/50016-0

Handbook of Vertebrate Immunology 1998

DOI: 10.1016/b978-012546401-7/50016-0

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Sheep Immunology and Goat Peculiarities

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Cited by 2 publications

References 504 publications

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Rechallenge of previously-infected pregnant ewes with Chlamydophila abortus

et al. 2005

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In an attempt to ascertain the means whereby previous exposure to Chlamydophila (C.) abortus can protect against the re-occurrence of enzootic abortion of ewes (EAE), ten previously-exposed ewes were intravenously rechallenged with a large infective dose of C. abortus during pregnancy. The patterns of development of chlamydial placentitis and its sequelae closely resembled that observed following first-time challenge of previously-naïve ewes, although placentitis appeared to develop more slowly following rechallenge infection and none of the rechallenged ewes aborted. Chorioallantoic and foetal pathology and foetal immune responses were qualitatively similar whilst the local maternal response to C. abortus infection of the endometrium did not appear to differ in rechallenged and first-time challenged sheep. This demonstrates that if C. abortus reaches the foetal side of the placenta, a stereotypical response is elicited, regardless of the status of maternal immunity. Therefore it appears that in natural circumstances, acquired immunity of the dam protects against the re-occurrence of EAE by preventing the causative agent from reaching the susceptible foetal trophoblast.

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Rechallenge of previously-infected pregnant ewes with Chlamydophila abortus

et al. 2005

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Distribution of Lymphocyte Subsets in the Small Intestine Lymphoid Tissue of 1‐Month‐Old Lambs

Corpa

Juste

Marı́n

et al. 2001

Anat Histol Embryol

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Distribution of lymphocyte subpopulations along the small intestine lymphoid tissue has been examined in 1-month-old lambs using flow cytometric and immunohistochemical techniques. Monoclonal antibodies against CD4, CD8, gamma delta, CD45R and B receptors have been employed in samples from continuous ileal Peyer's patch (IPP), discrete jejunal Peyer's patches (JPP), ileocaecal valve lymphoid tissue (ICVPP), mesenteric lymph node (MLN) and intra-epithelial (IEL) and lamina propria (LPL) lymphocytes. Histological studies were also done. Differences in the lymphocyte distribution have been observed between some of the regions examined, especially between IPP and JPP for most of the markers. A remarkable feature was the existence of morphological and lymphocyte distribution differences between ICVPP and IPP, locations that had been traditionally considered as similar. The antibody against CD45R receptor used in this study, that was supposed to mark B cells and some T cells, detected cell populations located in the dome of the follicles in all the samples, whereas the centre was negative. Lymphocytes positive to the B marker employed were located mainly in the centre, suggesting that both antibodies would mark B cells in different maturation status.

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Sheep Immunology and Goat Peculiarities

Cited by 2 publications

References 504 publications

Rechallenge of previously-infected pregnant ewes with Chlamydophila abortus

Rechallenge of previously-infected pregnant ewes with Chlamydophila abortus

Distribution of Lymphocyte Subsets in the Small Intestine Lymphoid Tissue of 1‐Month‐Old Lambs

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