Shengmai (a traditional Chinese herbal medicine) for heart failure

Zheng, Huixian; Chen, Yanling; Chen, Jin; Kwong, Joey S.W.; Xiong, Wenmei

doi:10.1002/14651858.cd005052.pub3

Cited by 14 publications

(10 citation statements)

References 12 publications

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“…In contrast to anthracycline-related cardiomyopathy and heart failure, cardiotoxicity of trastuzumab is often manifested by asymptomatic left ventricular ejection fraction reduction, palpitations, and – less often – by heart failure. Sheng-mai-san is a famous herbal formula used for the treatment of heart failure and ischemic heart disease 45. The present study found that many FBC patients treated with chemotherapy used sheng-mai-san concurrently.…”

Section: Discussionmentioning

confidence: 51%

Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

Wang¹,

Chang²,

Chen³

et al. 2014

PPA

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BackgroundMany female breast cancer (FBC) patients take Chinese herbal medicine (CHM) and Western medication (WM) concurrently in Taiwan. Despite the possibility of interactions between the CHM and WM mentioned in previous studies, the pattern of these coprescriptions in FBC patients remains unclear. Hence, the aim of the present study is to investigate the utilization of coprescriptions of CHM and WM among the FBC patients in Taiwan.MethodsThe study was a cross-sectional survey using the sampled cohort in 2009 obtained from the National Health Insurance Research Database in Taiwan. There were 3,507 FBC patients identified from the registry for catastrophic illness patients. Ambulatory visit records, corresponding prescriptions, and the data of beneficiaries belonging to the FBC patients were further extracted. A total of 1,086 FBC patients used CHM at least once. CHM and WM prescribed within any overlapping duration were defined as coprescriptions.ResultsThere were 868 (80.0%) patients simultaneously receiving CHM and WM. A total of 4,927 CHM prescriptions and 6,358 WM prescriptions were prescribed concurrently. Among these coprescriptions, the most frequently used CHM was jia-wei-xiao-yao-san (21.2%), and the most frequently coprescribed WM was acetaminophen (38.9%), followed by tamoxifen (25.5%). There were 346 patients using systemic adjuvant therapy and CHM concurrently. The most commonly coprescribed CHM with chemotherapy, endocrine therapy, and trastuzumab was xiang-sha-liu-jun-zi-tang, jia-wei-xiao-yao-san, and zhi-gan-cao-tang, respectively.ConclusionThe combined use of CHM with WM is prevalent. The main purpose of combining CHM with systemic cancer treatment is to alleviate the treatment-related adverse effects. However, the combination may result in the potential risk of drug–herb interactions. Further clinical studies are needed to evaluate the efficacy and safety of the CHM and WM coprescriptions for FBC patients.

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Section: Discussionmentioning

confidence: 51%

Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

Wang¹,

Chang²,

Chen³

et al. 2014

PPA

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“…In this formula, ginseng root serves to strengthen qi , dwarf lily turf replenishes yin , whereas magnolia fruit takes up the roles of consolidating qi and yin , and arresting sweating. The traditional usage of the Shengmai formula has led to intensive studies of its cardiovascular pharmacology; and evidence is now emerging to indicate potential clinical applications in the treatment of cardiac diseases such as intradialytic hypotension [ 20 ], heart failure [ 21 , 22 ], and viral myocarditis [ 23 ].…”

Section: Theoretical Perspectives On Herb-herb Combinationmentioning

confidence: 99%

Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives

et al. 2013

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Herb-herb combinations have been used in Chinese medicine practice for thousands of years, yet scientific evidence of their therapeutic benefits is lacking. With increasing interest in shifting from the one-drug-one-target paradigm to combination therapy or polypharmacy to achieve therapeutic benefits for a number of diseases, there is momentum to explore new knowledge by tapping the past empirical experiences of herb-herb combinations. This review presents an overview of the traditional concept and practice of herb-herb combination in Chinese medicine, and highlights the available scientific and clinical evidence to support the combined use of herbs. It is hoped that such information would provide a lead for developing new approaches for future therapeutic advancement and pharmaceutical product development. Very likely modern technologies combined with innovative research for the quality control of herbal products, identification of active components and understanding of the molecular mechanism, followed by well-designed animal and clinical studies would pave the way in advancing the wealth of empirical knowledge from herb-herb combination to new therapeutic modalities.

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“…Shengmai injection, originating from a traditional Chinese medicine formula composed of Panax ginseng , Ophiopogon japonicas and Schisandra chinensis , is widely used in China for the treatment of cardiac emergency, such as coronary atherosclerotic cardiopathy, viral myocarditis and myocardial infarction (Zheng et al , ; Chen et al , ; Liu et al , ). Chemical and pharmacological studies have demonstrated that ginsenosides, ophiopogonins and lignan isolated from ginseng, Ophiopogon and Schisandra , respectively, are the major constituents responsible for the pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Development of a sensitive LC‐MS/MS method for simultaneous quantification of eleven constituents in rat serum and its application to a pharmacokinetic study of a Chinese medicine Shengmai injection

Zhan

Shao

Fan

et al. 2014

Biomedical Chromatography

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A sensitive LC-MS/MS method was developed and validated for simultaneous quantification of 11 constituents, ginsenoside Rg1, Re, Rf, Rg2, Rb1, Rd, Rc, ophiopogonin D, schisandrin, schisandrol B and schizandrin B, in rat serum using digoxin as the internal standard (IS). The serum samples were pretreated and extracted with a two-step liquid-liquid extraction. Chromatographic separation was achieved on a C18 analytical column with a proper gradient elution using 0.02% acetic acid aqueous solution and 0.02% acetic acid-acetonitrile as mobile phase at a flow rate of 0.5 mL/min. MS detection was performed using multiple reaction monitoring via an electrospray ionization source. Good linearity was observed in the validated concentration range for every analyte (r(2) ≥0.9929), and the lower limits of quantitation of the analytes were in the range of 0.044-1.190 ng/mL in rat serum. Intra- and inter-day precisions were <14.2%. The accuracy expressed as recovery was within the range of 85.1-112.8%. The extraction recoveries were >75.8%.The validated method was successfully applied to a pharmacokinetic study of all analytes in rats after single intravenous administration of Shengmai injection.

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Shengmai (a traditional Chinese herbal medicine) for heart failure

Cited by 14 publications

References 12 publications

Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

Coprescription of Chinese herbal medicine and Western medication among female patients with breast cancer in Taiwan: analysis of national insurance claims

Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives

Development of a sensitive LC‐MS/MS method for simultaneous quantification of eleven constituents in rat serum and its application to a pharmacokinetic study of a Chinese medicine Shengmai injection

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