Brinjal shoot and fruit borer (BSFB) (Leucinodes orbonalis (Gennadius)) causes significant economic harm to brinjal (Solanum melongena L.) production. The present study was carried out at research farm of ICAR-Indian Institute of Vegetable Research, Varanasi, Uttar Pradesh to standardize the optimum dose of chlorantraniliprole 18.5% sc (CAP) to manage BSFB under field conditions and to quantify the residue of CAP in brinjal for food safety. Three CAP doses (20, 40, and 80 g a.i./ha) along with an old generic insecticide (cypermethrin 25% ec @50 g a.i./ ha) as a check and an untreated control were examined during 2017–19. CAP applications of 40 and 80 g a.i./ha were similarly efficient against BSFB and resulted in a significantly higher yield of brinjal fruit. The population of borers was reduced significantly in the treatment, CAP @40 g a.i./ha as compared to the untreated control. Phytotoxic effects of chlorantraniliprole 18.5% sc were not observed. Natural enemies of the brinjal ecosystem, viz. predatory pentatomid bug [Eocanthecona furcellata (Wolff)], ladybird beetle [Coccinella septempunctata (Linn.)], and spider were unaffected by CAP treatment. When CAP was applied @40 and 80 g a.i./ha, chlorantraniliprole degraded from brinjal fruits with half-lives of 4.85 and 7 days, and pre-harvest intervals of 7 and 10 days were prescribed, respectively. Even at greater application doses, residues in a person's meals were found to be lower than the maximum permissible intake (24.96 mg/person/day) in day-zero samples. Chlorantraniliprole @40 g a.i./ha can be an effective alternative to the conventional insecticides against BSFB in brinjal, ensuring quality, sustainability, and safety.