Shift of tumor features in patients with clinically localized prostate cancer undergoing radical prostatectomy since the beginning of the PSA era

Augustin, Herbert; Auprich, Marco; Stummvoll, P.; Lipsky, Katja; Pummer, Karl; Petritsch, P.

doi:10.1007/s00508-006-0608-z

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…However, in the last decade, a stage migration of PC has been observed. PC has been detected increasingly due to a pathological PSA level only and has shifted significantly to more OC stages (31,32). Consequently, tumors with ECE and with seminal vesicle invasion have decreased distinctly.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of 3-Tesla magnetic resonance imaging for the staging of prostate cancer in comparison to the partin tables

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Accuracy of 3-Tesla magnetic resonance imaging for the staging of prostate cancer in comparison to the partin tables

et al. 2009

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“…As a result of improvements in diagnostic procedures and increased screening in most countries, prostate cancer is currently usually diagnosed at the earlier stages (i.e. more organconfined disease) than previously (211)(212)(213) . Epidemiological studies that have examined the association between obesity and risk of prostate cancer have provided conflicting results.…”

Section: Obesity and Prostate Cancermentioning

confidence: 99%

Obesity and cancer

2008

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The prevalence of obesity, defined as a BMI of ‡ 30 . 0 kg/m 2 , has increased substantially over previous decades to about 20 % in industrialized countries, and a further increase is expected in the future. Epidemiological studies have shown that obesity is a risk factor for: postmenopausal breast cancer; cancers of the endometrium, colon and kidney; malignant adenomas of the oesophagus. Obese subjects have an approximately 1 . 5-3 . 5-fold increased risk of developing these cancers compared with normal-weight subjects, and it has been estimated that between 15 and 45 % of these cancers can be attributed to overweight (BMI 25 . 0-29 . 9 kg/m 2 ) and obesity in Europe. More recent studies suggest that obesity may also increase the risk of other types of cancer, including pancreatic, hepatic and gallbladder cancer. The underlying mechanisms for the increased cancer risk as a result of obesity are unclear and may vary by cancer site and also depend on the distribution of body fat. Thus, abdominal obesity as defined by waist circumference or waist :hip ratio has been shown to be more strongly related to certain cancer types than obesity as defined by BMI. Possible mechanisms that relate obesity to cancer risk include insulin resistance and resultant chronic hyperinsulinaemia, increased production of insulin-like growth factors or increased bioavailability of steroid hormones. Recent research also suggests that adipose tissue-derived hormones and cytokines (adipokines), such as leptin, adiponectin and inflammatory markers, may reflect mechanisms linked to tumourigenesis. Obesity: Cancer risk: Cancer site: Body fat distributionThe prevalence of obesity has increased substantially over previous decades in most industrialized countries, and a further increase is expected in the future

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“…Currently, more men are presenting with well-differentiated tumors, low PSA levels, and nonpalpable disease. This dramatic shift in presentation, which may be due to PSA use, has caused a major stage migration for prostate cancer, with nearly 80% of newly diagnosed cases revealing only localized disease [11,12]. In patients with localized prostate cancer, radical prostatectomy is the most effective treatment tool and offers the best chance of a cure [13].…”

Section: Discussionmentioning

confidence: 99%

The Role of Endorectal Magnetic Resonance Imaging in Predicting Extraprostatic Extension and Seminal Vesicle Invasion in Clinically Localized Prostate Cancer

Park

Kim

et al. 2010

Korean J Urol

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PurposeWe aimed to assess the clinical value of endorectal magnetic resonance imaging (MRI) in predicting extraprostatic extension and seminal vesicle invasion in patients with clinically localized prostate cancer.Materials and MethodsA total of 54 patients who underwent radical prostatectomy for clinically localized prostate cancer were retrospectively analyzed. The findings of endorectal MRI, performed at least 3 weeks after biopsy, were compared with the pathological results of radical prostatectomy specimens. The sensitivity, specificity, and accuracy of the detection of extraprostatic extension and seminal vesicle invasion were calculated.ResultsThe sensitivity, specificity, and accuracy of the endorectal MRI findings were 50.0%, 82.6%, and 77.8% for the detection of extraprostatic extension, respectively, and 75.0%, 92.0%, and 90.7% for the detection of seminal vesicle invasion, respectively. The sensitivity of endorectal MRI in the detection of extraprostatic extension improved as the Gleason score increased.ConclusionsEndorectal MRI findings demonstrated modest sensitivity for predicting extraprostatic extension, whereas specificity was relatively high. In addition, endorectal MRI showed better sensitivity for detecting high-grade tumors.

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Shift of tumor features in patients with clinically localized prostate cancer undergoing radical prostatectomy since the beginning of the PSA era

Abstract: During the 12-year period, PC was increasingly detected on the basis of a pathological PSA level only and shifted significantly to more organ-confined stages. With a time delay, these findings are consistent with trends observed in large centers in the USA.

Cited by 4 publications

References 32 publications

Accuracy of 3-Tesla magnetic resonance imaging for the staging of prostate cancer in comparison to the partin tables

Accuracy of 3-Tesla magnetic resonance imaging for the staging of prostate cancer in comparison to the partin tables

Obesity and cancer

The Role of Endorectal Magnetic Resonance Imaging in Predicting Extraprostatic Extension and Seminal Vesicle Invasion in Clinically Localized Prostate Cancer

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